- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04661735
Intensive Care Unit Risk Score (ICURS)
Retrospective Analysis - Scoring Systems in Intensive Care Medicine
Study Overview
Status
Detailed Description
A scoring system usually consists of two parts - a score (a number reflecting the severity of the disease) and a probability model (equation indicating the probability of an event, e.g. the death of the patient in hospital). Scoring systems have been used in intensive care medicine for decades and can help to assess the effectiveness of treatment or identify comparable patients for study purposes. Scoring systems that are used in intensive care medicine are for example
- Acute Physiology, Age, Chronic Health Evaluation II (APACHE II)
- Simplified Acute Physiology Score II (SAPS II)
- Multiple Organ Dysfunction Score (MODS)
- Sequential Organ Failure Assessment (SOFA)
- Logistic Organ Dysfunction System (LODS)
- MPM II-Admission (Mortality Probability Models (MPM II)
- Organ Dysfunction and Infection score (ODIN)
- Three-Day Recalibrating ICU Outcomes (TRIOS)
- Glasgow coma score (GCS)
- Discharge Readiness Score (DRS) The above-mentioned scoring systems are already being collected regularly in the respective hospital's departments. In a recent study by Badawi et al. it could be shown that scoring systems allow more accurate predictions when calculated continuously. However, due to the patient collectives investigated, these results can only be transferred to other patient groups to a limited extent. Furthermore, only the scoring systems APACHE, SOFA and DRS were analyzed.
Therefore, in the present study, all of the above scoring systems will be calculated continuously (once per minute) using routine data from the digital patient records and optimized by applying machine learning and methods of time series analysis.
On the anesthesiologically managed intensive care units of the respective hospital, there is no campus-wide standard with regard to alarm management. Accordingly, we estimate the rate of alarm fatigue (ignoring alarms due to many false alarms) to be very high. In order to optimize the alarm management, alarms from the patient monitoring devices will be evaluated retrospectively and combined with the data mentioned above to determine, for example, whether more frequent alarms are to be expected for certain types of diseases (e.g. sepsis), or scores (e.g., high APACHE score) and how the alarm limit setting can be optimized.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Felix Balzer, Prof
- Email: data-science@charite.de
Study Contact Backup
- Name: Akira S Poncette, MD
- Email: data-science@charite.de
Study Locations
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Berlin, Germany, 10117
- Recruiting
- Charite Universtitaetsmedizin
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Contact:
- Felix Balzer, Prof. Dr. Dr.
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients with admission between 01.01.2006 and 30.09.2023
Exclusion Criteria:
- Patients under 18 years of age.
- Incomplete patient records.
- Intensive stay of less than 24 hours.
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Prediction of patient outcome
Time Frame: 2006 - 2023
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Identification of scores with a high on impact mortality, complications and length of stay in the intensive care unit
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2006 - 2023
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Predictive model for alarm load
Time Frame: 2020 - 2023
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Identification of items leading to a high alarm load measured by number of alarm per day per bed in the intensive care unit
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2020 - 2023
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Predictive model for actionable alarms
Time Frame: 2020 - 2023
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Identification of items leading to a high number of actionable alarms measured by number of actionable alarms per day per bed in the intensive care unit
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2020 - 2023
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Collaborators and Investigators
Investigators
- Principal Investigator: Felix Balzer, Prof, Charite University, Berlin, Germany
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- ICURS
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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