Prevalence of Dementia and Delirium in Outpatient Clinics (DESTAN Trial)

Gulhane Training and Research Hospital

The aim of this study is to assess the prevalence and etiologic risk factors of delirium in outpatient geriatric patients and also hospitalized patients.

Study Overview

• Status: Recruiting
• Conditions: Delirium in Old Age; Delirium Superimposed on Dementia; Delirium With Dementia
• Intervention / Treatment: Diagnostic test: Confussion assessment method (CAM); Diagnostic test: Dementia diagnosis

Detailed Description

This study aimed to investigate the frequency of delirium and examines the association between delirium and other possible risk factors and prognostic factors (dementia etc.)

• Study Type: Observational
• Enrollment (Anticipated): 714

Contacts and Locations

Study Locations

• Turkey
  • Ankara, Turkey, 06670
    • Recruiting
    • Gulhane Training and Research Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Community-dwelling older adults (65 years and older)

Description

Inclusion Criteria:

• We included all 65 years older patients who evaluated according to a comprehensive geriatric assessment that is consistently performed during admission to the outpatients' clinic of the hospital.

Exclusion Criteria:

• Exclusion criteria were serious psychiatric disorders such as schizophrenia or major depression.

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Retrospective

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Delirium with dementia; Delirium was detected using the short form of the Confusion Assessment Method (CAM) both at admission and daily throughout the hospital stay. Cognitive status was determined using the Mini-Mental State Exam, Clinical Dementia Rating (CDR). Dementia was defined by a CDR score of 1. The primary independent variable was a composite of delirium and dementia diagnosis, and we examined the overlap by categorizing the cases into four groups: no delirium or dementia, dementia alone, delirium alone, and DSD.	Diagnostic test: Confussion assessment method (CAM); Participants enrolled in the Delirium group according to the CAM.; Diagnostic test: Dementia diagnosis; Participants enrolled in the Dementia group according to the CDR scores and MMSE scores and DSM4/5 criteria
Dementia without Delirium; Delirium was detected using the short form of the Confusion Assessment Method (CAM) both at admission and daily throughout the hospital stay. Cognitive status was determined using the Mini-Mental State Exam, Clinical Dementia Rating (CDR). Dementia was defined by a CDR score of 1. The primary independent variable was a composite of delirium and dementia diagnosis, and we examined the overlap by categorizing the cases into four groups: no delirium or dementia, dementia alone, delirium alone, and DSD.	Diagnostic test: Dementia diagnosis; Participants enrolled in the Dementia group according to the CDR scores and MMSE scores and DSM4/5 criteria
Delirium without Dementia; Delirium was detected using the short form of the Confusion Assessment Method (CAM) both at admission and daily throughout the hospital stay. Cognitive status was determined using the Mini-Mental State Exam, Clinical Dementia Rating (CDR). Dementia was defined by a CDR score of 1. The primary independent variable was a composite of delirium and dementia diagnosis, and we examined the overlap by categorizing the cases into four groups: no delirium or dementia, dementia alone, delirium alone, and DSD.	Diagnostic test: Confussion assessment method (CAM); Participants enrolled in the Delirium group according to the CAM.
No dementia, No delirium; Delirium was detected using the short form of the Confusion Assessment Method (CAM) both at admission and daily throughout the hospital stay. Cognitive status was determined using the Mini-Mental State Exam, Clinical Dementia Rating (CDR). Dementia was defined by a CDR score of 1. The primary independent variable was a composite of delirium and dementia diagnosis, and we examined the overlap by categorizing the cases into four groups: no delirium or dementia, dementia alone, delirium alone, and DSD.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
frequency of Mortality	1st year mortality according to the electronic national data base	1 year fellow-up

Collaborators and Investigators

• Sponsor: Gulhane Training and Research Hospital
• Investigators: Principal Investigator: Mehmet Naharcı, Saglik Bilimleri Universitesi

Study record dates

Study Major Dates

• Study Start (Actual): August 5, 2021
• Primary Completion (Actual): October 5, 2022
• Study Completion (Anticipated): November 11, 2025

Study Registration Dates

• First Submitted: July 4, 2021
• First Submitted That Met QC Criteria: July 21, 2021
• First Posted (Actual): July 22, 2021

Study Record Updates

• Last Update Posted (Actual): October 25, 2022
• Last Update Submitted That Met QC Criteria: October 23, 2022
• Last Verified: October 1, 2022

More Information

Terms related to this study

• Keywords: Outpatient; Dementia; Mortality; Delirium; Etiology
• Additional Relevant MeSH Terms: Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurologic Manifestations; Confusion; Neurobehavioral Manifestations; Neurocognitive Disorders; Neurodegenerative Diseases; Tauopathies; Delirium; Dementia; Alzheimer Disease
• Other Study ID Numbers: 2020-382

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No