- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05017870
[KSR-001-P01]Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetic Characteristic of KSR-001
August 23, 2021 updated by: Kukje Pharma
A Randomized, Double-blinded, Placebo-controlled, Dose-escalation Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetic Characteristic of KSR-001 in Healthy Male Volunteers
The purpose of this study is to evaluate the safety, tolerability and pharmacokinetic characteristic of KSR-001.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
After single dose, safety and local tolerability were confirmed and repeated test was conducted according to the investigator's judgment.
Study Type
Interventional
Enrollment (Actual)
24
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Seongnam-si, Korea, Republic of
- Kukje Pharma
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
19 years to 45 years (ADULT)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- Male aged between 19 and 45 years of age inclusive, at the time of signing the informed consent.
- Body weight >= 50 kilogram and ideal body weight within the range ±20%.
- Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form.
Exclusion Criteria:
- A subject who has symptoms of suspected acute disease at the time of screening.
- Subjects with a history of abnormal digestive organ, kidney, respiratory, neuroendocrine, cardiovascular, hemato-oncology, urinary, musculoskeletal, immune, the nose and ears, psychiatry, stomach system.
- A subject determined to be unsuitable as a subject through a physical examined during screening.
- A subject who is determined to be unsuitable as a subject through an ophthalmologic examination performed during screening.
- A subject with a history of ophthalmic surgery, trauma and chronic diseases.
- A subject who has acute or chronic eye disease requiring the use of local eye drops at the time of screening.
- Subjects who need to wear contact lenses during clinical trial period.
- A subject with clinically significant allergic disease.
- A subject with a history of drug abuse.
- History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the investigator contraindicates their participation.
- The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 90 days of the biological effect of the investigational product (whichever is longer).
- A subject who takes drugs that induce and inhibit drug metabolises such as barbital medicines within one month before the administration of clinical trial drugs.
- A subject who donates blood to the whole blood within 60 days before the administration of a clinical trial drug or a person who donates blood to the component within 20 days before the administration of a clinical trial drug.
- A subject who has taken a specialty drug or herbal medicine within 14 days of administration of a clinical trial drug or a general medicine or vitamin formulation within 7 days.
- A subject who can not continually ingest caffeine or ingest caffeine-containing foods during the period from 24 hours to discharge from hospital.
- A subject who can not drink alcohol continuously or during the period from 24 hours to discharge from hospital.
- A subject who can not smoke excessively or quit smoking during the period from 24 hours to discharge from hospital.
- A subject who investigator that a tester is unsuitable for participating in clinical trials due to other reasons.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: DOUBLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: KSR-001-01
Participants received KSR-001-01 for 6 days.
|
(0 day) eye drops received one drop to both eyes once a day (1~5 day) eyedrops recieved one drop to both eyes four times a day
Other Names:
|
EXPERIMENTAL: KSR-001-02
Participants received KSR-001-02 for 6 days.
|
KSR-001-02
|
EXPERIMENTAL: KSR-001-03
Participants received KSR-001-03 for 6 days.
|
KSR-001-03
|
PLACEBO_COMPARATOR: KSR-001-04
Participants received KSR-001-04 for 6 days.
|
(0 day) eye drops received one drop to both eyes once a day (1~5 day) eyedrops recieved one drop to both eyes four times a day
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cmax
Time Frame: 6 days
|
Pharmacokinetic Characteristics
|
6 days
|
Tmax
Time Frame: 6 days
|
Pharmacokinetic Characteristics
|
6 days
|
t1/2
Time Frame: 6 days
|
Pharmacokinetic Characteristics
|
6 days
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
December 2, 2018
Primary Completion (ACTUAL)
June 14, 2019
Study Completion (ACTUAL)
January 15, 2020
Study Registration Dates
First Submitted
August 19, 2021
First Submitted That Met QC Criteria
August 23, 2021
First Posted (ACTUAL)
August 24, 2021
Study Record Updates
Last Update Posted (ACTUAL)
August 24, 2021
Last Update Submitted That Met QC Criteria
August 23, 2021
Last Verified
August 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- KSR-001-P01
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Dry Eye Syndromes
-
Singapore National Eye CentreCompleted
-
Singapore National Eye CentreCompleted
-
Alcon ResearchCompletedVisual Performance | Dry Eye Symptoms
-
Alcon ResearchCompletedModerate to Severe Dry Eye
-
Kao (Taiwan) CorporationChang Gung Memorial HospitalCompletedEye Fatigue | Dry Eye SymptomTaiwan
-
Centre for Contact Lens ResearchCoopervision, Inc.CompletedContact Lens Related Dry EyeCanada
-
OptovueCompleted
-
Bausch & Lomb IncorporatedCompletedDry Eye Disease (DED)United States
-
Horus PharmaEurofins Dermscan PharmascanRecruitingDry EyeFrance, Poland, Spain, United Kingdom
Clinical Trials on KSR-001
-
Kukje PharmaSamil Pharmaceutical Co., Ltd.CompletedDry Eye SyndromesKorea, Republic of
-
Toll Biotech Co. Ltd. (Beijing)Recruiting
-
Patagonia Pharmaceuticals, LLCCompletedCongenital IchthyosisUnited States
-
IntegoGen, LLCWithdrawnHidradenitis SuppurativaUnited States
-
JANSSEN Alzheimer Immunotherapy Research & Development...TerminatedAlzheimer's DiseaseUnited States
-
Frontera TherapeuticsRecruitingBiallelic RPE65 Mutation-associated Retinal DystrophyChina
-
Heartseed Inc.RecruitingHeart Failure | Ischemic Heart DiseaseJapan
-
Longbio PharmaActive, not recruitingMyelodysplastic Syndrome (MDS)China
-
Astrogen, Inc.RecruitingAutism Spectrum DisorderKorea, Republic of
-
StimuSILAnkara City Hospital Bilkent; Istanbul University - Cerrahpasa (IUC)RecruitingAndrogenetic Alopecia | Hair Loss | Male Pattern Baldness | Hair Loss/Baldness | Pattern BaldnessTurkey