- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05130554
XEN45 in the Treatment of Chinese Patients With Primary Open-angle Glaucoma
Glaucoma is the second most common blindness disease in the world, second only to cataracts. The current treatment of glaucoma is mainly to reduce intraocular pressure.At present, two commonly used surgical methods are trabeculectomy and implantation of drainage valve. These methods are superior to drug treatment in reducing intraocular pressure, but the effect duration of these two methods is not long, and there may be serious complications and failure.
Compared with traditional glaucoma surgery, MIGS may have better safety.The XEN45 gel implant is a collagen tube with a length of 6 mm and a diameter of 45 µm, which creates a new channel for drainage of aqueous humor by connecting the anterior chamber and the subconjunctival space. The implant is composed of porcine gelatin cross-linked with glutaraldehyde, and has good biocompatibility and tolerance. Therefore, after the advent of XEN45 products, more and more studies have shown that this treatment has excellent safety and effectiveness in reducing intraocular pressure in patients with open-angle glaucoma.
Considering that the XEN45 gel stent has been in the market for a relatively short time, we conducted this prospective study to investigate the effect of XEN45 surgery in the treatment of primary open-angle glaucoma, in order to support ophthalmologists in formulating the best surgical plan for patients. The promotion of this surgical method.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Guangdong
-
Guangzhou, Guangdong, China, 510060
- Zhognshan Ophthalmic Center, Sun Yat-sen University
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patients diagnosed with POAG;
- The visual acuity of the affected eye is greater than that of manual operation;
- Between 18 and 90 years old;
- No surgery or laser treatment within 90 days;
- Patients with other types of glaucoma whose intraocular pressure has not been controlled by traditional surgery or medication;
- The target quadrant has healthy conjunctiva and free movement without scars.
Exclusion Criteria:
- Angle-closure glaucoma;
- Active uveitis;
- Any corneal disease;
- Patients with eye infections two weeks before the operation;
- During pregnancy or lactation;
- Active neovascular glaucoma;
- Known or suspected allergy or sensitivity to pig products or glutaraldehyde.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: XEN45
The effect of XEN45 surgery on patients with primary open-angle glaucoma
|
The XEN45 gel implant is a collagen tube with a length of 6 mm and a diameter of 45 µm, which creates a new channel for drainage of aqueous humor by connecting the anterior chamber and the subconjunctival space.
The implant is composed of porcine gelatin cross-linked with glutaraldehyde, and has good biocompatibility and tolerance.This treatment method has excellent safety and effectiveness in reducing the intraocular pressure of patients with open-angle glaucoma.
At the same time, the operation is simple and safe.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
IOP (intraocular pressure) changes
Time Frame: 3 months after surgery
|
Compare the patient's IOP changes before and after surgery.
Complete success of the operation was defined as IOP≤21mmhg without any glaucoma drugs.
Qualified success is defined as the same intraocular pressure level but with medication.
Failure is defined as IOP> 21 mmHg and maximum tolerance of the drug
|
3 months after surgery
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
BCVA(Best corrected vision ability)changes
Time Frame: Baseline (before surgery) and 1 day, 1 week, 1 month, 3 months, 6 months, and 12 months after surgery
|
Evaluate the patient's BCVA changes before and after surgery
|
Baseline (before surgery) and 1 day, 1 week, 1 month, 3 months, 6 months, and 12 months after surgery
|
anti-glaucoma drugs changes
Time Frame: Baseline (before surgery) and 1 day, 1 week, 1 month, 3 months, 6 months, and 12 months after surgery
|
Compare the amount of patient's anti-glaucoma drugs before and after surgery
|
Baseline (before surgery) and 1 day, 1 week, 1 month, 3 months, 6 months, and 12 months after surgery
|
IOP (intraocular pressure) changes
Time Frame: Baseline (before surgery) and 1 day, 1 week, 1 month,6 month and 12 months after surgery
|
Compare the patient's IOP changes before and after surgery.
Complete success of the operation was defined as IOP≤21mmhg without any glaucoma drugs.
Qualified success is defined as the same intraocular pressure level but with medication.
Failure is defined as IOP> 21 mmHg and maximum tolerance of the drug
|
Baseline (before surgery) and 1 day, 1 week, 1 month,6 month and 12 months after surgery
|
Collaborators and Investigators
Collaborators
Investigators
- Study Chair: Mingkai Lin, M.D,Ph.D, Zhognshan Ophthalmic Center, Sun Yat-sen University
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2021KYPJ172
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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