Quality of the Cardio-pulmonary Resuscitation

Cardiopulmonary Resuscitation; Epidemiology, Quality, Survival and Injuries.

Patients having sudden cardiac arrest have very poor prognosis. It is devastating for patient and family. But also very expensive for nations economics when working-age people die or disable due to cardiac arrest. Recent studies have shown that high quality of cardiopulmonary resuscitation (CPR) and minimized delays increases the survival after cardiac arrest. In this objective prospective study we will use Zoll´s X Series defibrillator on every emergency medicine systems (EMS´s) unit in Pirkanmaa area, Finland, to collect information on CPR quality. Real CPR Help® will collect the information on depth, frequency and pauses during CPR. We will make an Utstein analysis on OHCA during one year period and compare the results on Utstein analysis made in the same area on 2013-2014. We will analyse the quality of CPR and compare it to the outcome from OHCA and neurological outcome 3 months after resuscitation. In addition we will analyse the CPR related injuries and compare these to the compression depth and number of persons performing CPR.

In one part of the study we will evaluate the incidence of OHCA in different risk areas of Pirkanmaa and analyse the influence of time delay and location to the outcome out of hospital and neurological outcome 3 months after resuscitation. We will also analyse if the time of post-resuscitation care before getting to the hospital or stenosis in carotid artery affects the outcome from OHCA and neurological outcome 3 months after resuscitation.

Study Overview

• Status: Recruiting
• Conditions: Cardiopulmonary Resuscitation

• Study Type: Observational
• Enrollment (Anticipated): 400

Contacts and Locations

• Study Contact: Name: Sanna Hoppu, PhD; Phone Number: +3583311611; Email: sanna.hoppu@pshp.fi
• Study Contact Backup: Name: Paula Mäki, MD; Phone Number: +3583311611; Email: paula.maki@pshp.fi

Study Locations

• Finland
  • Tampere, Finland, 33521
    • Recruiting
    • Tampere University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 100 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All cardiac arrest patients in Etelä-Pohjanmaa and Pirkanmaa, Finland

Description

Inclusion Criteria:

• cardiac arrest
• > 18 years of age

Exclusion Criteria:

• < 18 years of age
• prisoners

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort
Cardiac arrest; All patients having sudden cardiac arrest out-of-hospital in Pirkanmaa, Finland
ResusInj; OHCA survivors having CPR related injuries or carotid stenosis analyzed by CT
ResusCPC; OHCA survivors neurological outcome

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
QualityCPR	The success rate of current guidelines (depth and frequency of chest compression, epidemiology)	1 year
Neurological survival after CA	Neurological survival after CA	3 months after OHCA

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
CPR related injuries	Injuries detected in CT scanning or in autopsy	1 year
Stenosis of the carotid artery	Effect of the carotid artery stenosis to the neurological survival. Survivals having CPC 1-2 prior to the cardiac arrest and are taken to the ICU are scanned with carotid CTA after informed consent. The degree of stenosis will be compared to the CPC-level 3monts aften OHCA.	3 months after OHCA
the dispatch calls concerning OHCA	Analyze the key words and dispatch assisted CPR through the emergency call. All emergency call conserning OHCA patients will be listened. We will analyze the keywords which are used by layperson to describe patient having cardiac arrest. We will also analyze the amount of given dispatch assisted CPR and compare the amount to the primary rythm.	1 year
the quality of the postresuscitation care	The correlation of the duration and the quality of the postresuscitation care before getting in to the hospital and the outcome from OHCA	3 months after OHCA

Collaborators and Investigators

• Sponsor: Tampere University Hospital
• Collaborators: National Istitute For Health and Welfare, Finland
• Investigators: Study Director: Piritta Setälä, PhD, Tampere University Hospital; Study Director: Sanna Hoppu, PhD, Tampere University Hospital; Principal Investigator: Jyrki Ollikainen, MD, Tampere University Hospital; Study Director: Kati Järvelä, PhD, Tampere University Hospital; Principal Investigator: Valtteri Järvenpää, MB, Tampere University Hospital; Study Director: Ville Jalkanen, PhD, Tampere University Hospital; Study Director: Joonas Tirkkonen, PhD, Tampere University Hospital; Study Director: Heini Huhtala, PhD, Tampere University; Study Director: Mika Martiskainen, PhD, Finnish Institute for Health and Welfare; Study Director: Riikka Nevalainen, MD, Tampere University Hospital

Study record dates

Study Major Dates

• Study Start (ACTUAL): January 1, 2022
• Primary Completion (ANTICIPATED): March 31, 2023
• Study Completion (ANTICIPATED): July 1, 2023

Study Registration Dates

• First Submitted: January 3, 2022
• First Submitted That Met QC Criteria: February 10, 2022
• First Posted (ACTUAL): February 22, 2022

Study Record Updates

• Last Update Posted (ACTUAL): February 22, 2022
• Last Update Submitted That Met QC Criteria: February 10, 2022
• Last Verified: February 1, 2022

More Information

Terms related to this study

• Keywords: CPR, injuries, OHCA
• Other Study ID Numbers: R18100; R18163 (REGISTRY: ResusciCPC); R21124 (REGISTRY: ResusciCT)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No