- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05286398
Effect of Cleft Palate Repair Using Alveolar Extension Technique on Eruption and Growth
March 22, 2022 updated by: Mansoura University
Effect of Cleft Palate Repair Using Alveolar Extension Technique on Primary Dentition and Maxillary Arch Width
This study aimed to evaluate clinically the "Alveolar extension" technique for palatoplasty in cases of primary closure of cleft palate regarding its effect on:
- Eruption of Primary dentition.
- Maxillary primary teeth undergoing eruption.
- The maxillary arch growth.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Cleft lip and palate represent the most common of the craniofacial anomalies.
They are severe congenital malformations with a worldwide frequency ranging between 0.28 and 3.74 per 1000 live births.
Cleft lip and palate occur in around 3 out of every 1000 infants in Egypt.
Infants born with cleft palates always have eating difficulties due to a lack of oro-nasal seal and also have speaking difficulties due to velopharyngeal insufficiency.
To ensure optimal care, the cleft team may include oral surgeons, plastic surgeons, pediatric dentists, orthodontists, and medical specialists in genetics, otolaryngology, pediatrics, and psychiatry.
These caregivers evaluate the medical condition and development of the patient, as well as dental and oral health, facial esthetics, psychological condition, and developing of hearing and speech.
Pediatric dentists are critical members of this team because they are responsible for the patient's overall dental health.
A variety of dental anomalies and malocclusions are associated with cleft palate; these may occur as a result of primary defects being repaired surgically.
The management of the cleft patient starts with an early focus on newborn's needs.
Surgical repair of cleft palates (Palatoplasty) is typically performed by one year of age, primarily to facilitate the development of normal speech, as this coincides with the age at which the majority of children begin to speak.
Hearing and swallowing are improved by proper alignment of the soft palatal musculature.
The ideal palatoplasty technique is one that results in perfect speech without impairing maxillofacial growth or hearing.
There are numerous surgical techniques for cleft palate repair, each with numerous variations.
Nevertheless, a few of these techniques are widely used.
Veau Wardill Kilner Palatoplasty, von Langenbeck, Bardach Two flap Palatoplasty were the most common techniques of palatoplasty.
These techniques leave a large raw area along the alveolar margin, exposing bare bone.
With secondary intention, the raw area heals.
This results in palate shortening and velopharyngeal insufficiency.
Additionally, the scar tissue adjacent to the alveolar margin results in deformity of the alveolar ridge and dental malalignment.
It was found that lateral incision reduced the maxillary growth more than mucoperiosteal palatal detachment only.
Additionally, some studies discovered that when matched normals are compared to individuals with unoperated clefts either lip or palate, the cranial base and skeletal face are not significantly malrelated.
These findings suggest that cleft patient possess normal potential and mechanism of growth.
The alveolar mucoperiosteum is deprived of blood supply from the facial artery in traditional lip repair procedures.
Later, during palate repair, the palatal incisions isolate the palatal tissues from the greater palatine artery, altering the alveolar mucoperiosteum from a highly blood supplied zone between the two arteries into a tissue that is predominantly supported by osseous backflow.
Thus, the disruption of palatal growth is considered in this perspective.
The Alveolar Extension Palatoplasty (AEP) technique provide tension free flap, less palatal bone exposure after the surgery ,as the raw area is on the alveolar crest or tooth margin.
It preserves blood supply of the palatal gingiva and periosteum.
The studies on the influence of that advantage as well as the alveolar crest incision on unerupted primary teeth are scanty.
So, it will be fruitful to study the effect of AEP on teeth undergoing eruption with alveolar bone and maxilla growth.
Study Type
Interventional
Enrollment (Actual)
16
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Dakahliya
-
Mansoura, Dakahliya, Egypt, 35511
- Mansoura university
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
9 months to 1 year (Child)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Both sexes.
- The age range from 9-12 month.
- Has a complete cleft palate.
- Medically fit for general anesthesia.
- Patients who haven't received any previous palatal repair.
Exclusion Criteria:
- Syndromic patients.
- Medically compromised patients contradicting operation.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: Control group
|
diagnostic impression for maxillary arch
|
Experimental: Bradach group
|
diagnostic impression for maxillary arch
Surgical closure of palatal defect
|
Experimental: AEP group
|
diagnostic impression for maxillary arch
Surgical closure of palatal defect
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
eruption of primary molars
Time Frame: 6 month
|
eruption of primay canine and primary first molar
|
6 month
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Growth
Time Frame: 6 monrth
|
maxillary arch width
|
6 monrth
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
December 22, 2019
Primary Completion (Actual)
January 1, 2021
Study Completion (Actual)
January 16, 2022
Study Registration Dates
First Submitted
March 7, 2022
First Submitted That Met QC Criteria
March 9, 2022
First Posted (Actual)
March 18, 2022
Study Record Updates
Last Update Posted (Actual)
March 23, 2022
Last Update Submitted That Met QC Criteria
March 22, 2022
Last Verified
September 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- A09060819
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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