- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05292170
Influences of Female Sex and Reproductive Hormones on Physiological Aspects of Heat Acclimation
May 10, 2023 updated by: United States Army Research Institute of Environmental Medicine
Women are often understudied in thermal physiology research, leaving recommendations for Soldier safety and performance in hot conditions based largely on data collected in men.
Female sex hormones estradiol and progesterone clearly have non-reproductive physiological effects, including influences on thermoregulatory and cardiovascular function.
However, mechanisms of differing physiological adaptations to repeated heat exposure (i.e., heat acclimation) as a function of reproductive hormone status have yet to be investigated in a systematic way.
Understanding possible sex differences in adaptation or mechanisms for adaptation during heat acclimation is important to ultimately optimize interventions to maximize soldier health and safety during training and deployment in the heat.
Our goals in the present study are to evaluate physiological and biophysical responses to a standard heat acclimation protocol in a group of young, healthy men and women.
Thirty individuals (n=10 males, n=10 women with a low hormonal status (i.e.
early follicular phase), n=10 women with a high hormonal status (i.e.
midluteal phase)) will complete 10 consecutive days of exercise (treadmill walking: 3.1 mph/2% grade) in the heat (40°C /40% relative humidity) up to 3hr per day.
Changes in core temperature, heart rate, and sex hormones will be assessed to examine differences in thermoregulatory response to heat acclimation.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
40
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Gabrielle EW Giersch, PhD
- Phone Number: 5082062421
- Email: gabrielle.e.giersch.ctr@mail.mil
Study Locations
-
-
Massachusetts
-
Natick, Massachusetts, United States, 01760
- Recruiting
- U.S. Army Research Institute of Environmental Medicine
-
Contact:
- Gabrielle EW Giersch, PhD
- Phone Number: 508-206-2421
- Email: gabrielle.e.giersch.ctr@mail.mil
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 40 years (Adult)
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
• Males and females, age 18-40 y (17 y for active duty military)
- Eumenorrheic females (menstrual cycle length between 24-35 days) or females taking oral contraceptives
- In good health as determined by OMSO (Office of Medical Support and Oversight) General Medical Clearance and willing to report all medications and dietary supplements (i.e. cold medication, Tylenol. Aleve) to the PI and OMSO.
- Passed his/her most recent Army Combat Fitness Test (ACFT) (military volunteers only) or exercise at least 2 times per week (civilian volunteers)
- Willing to not exercise, or drink alcoholic beverages for 24 hours before each testing session
- Willing to not consume caffeine 12 hours prior to any testing sessions
- Willing to refrain from additional moderate to strenuous physical activity throughout testing period
- Males and females with BMI <30
Exclusion Criteria:
• Females who are pregnant or planning to become pregnant during the study
- Females utilizing implantable contraception (intrauterine device, implantable bar)
- Tested positive for COVID-19 within the past 30 days.
- Taking prescription or over the counter medication, other than a contraceptive (unless approved by OMSO and Principal Investigator (PI))
- Tobacco users, or anyone who has used tobacco within the last four months
- Physical problems/injuries that would affect walking or running on a treadmill
- Allergy to skin adhesive
- Heart, lung, kidney, muscle, endocrine, or nerve disorder(s)
- History of heat intolerance or orthostatic intolerance
- Diagnosed and/or treated for fluid/electrolyte imbalance within the last 30 days
- History of obstructive disease of the gastrointestinal tract including (but not limited to) diverticulosis, diverticulitis and inflammatory bowel disease, peptic ulcer disease, Crohn's disease, ulcerative colitis.
- Scheduled MRI during testing
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Males
10 consecutive day heat acclimation in males
|
10 consecutive days of heat acclimation
|
Experimental: Females + high hormones
10 consecutive day heat acclimation in females with high hormonal dose
|
10 consecutive days of heat acclimation
|
Experimental: Females + low hormones
10 consecutive day heat acclimation in females with low hormonal dose
|
10 consecutive days of heat acclimation
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Heart rate
Time Frame: 10 days
|
10 days
|
Core temperature
Time Frame: 10 days
|
10 days
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
October 1, 2021
Primary Completion (Anticipated)
September 1, 2024
Study Completion (Anticipated)
September 1, 2025
Study Registration Dates
First Submitted
March 14, 2022
First Submitted That Met QC Criteria
March 14, 2022
First Posted (Actual)
March 23, 2022
Study Record Updates
Last Update Posted (Estimate)
May 11, 2023
Last Update Submitted That Met QC Criteria
May 10, 2023
Last Verified
May 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 21-07Hc
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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