- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06389604
Preparing for Heat Waves - Enhancing Human Thermophysiological Resilience (Prep4heat)
April 24, 2024 updated by: Maastricht University Medical Center
As the ongoing progression of climate change exposes individuals to elevated temperatures and an escalating frequency of extreme heat events, the risk of more intense and prolonged heat waves raises significant concerns for public health, particularly among vulnerable populations.
The physiological response to acute heat stress involves involuntary thermolytic reactions that may strain the cardiovascular system, especially in individuals with pre-existing vulnerabilities.
Heat acclimation has been identified as a potential strategy to enhance thermoregulation and mitigate the adverse effects of heat stress.
While existing research primarily focuses on athletes and military, this study aims to investigate the impact of a practical heat acclimation strategy, combining passive and active heat exposure, on thermophysiological, cardiovascular and metabolic parameters in healthy overweight adults.
The study targets a population at increased risk for heat-related complications, seeking to provide realistic guidelines for broader application when a heat wave appears on the weather forecast.
Study Overview
Status
Not yet recruiting
Intervention / Treatment
Detailed Description
A non-randomized, within-subject experimental trial will be conducted.
The complete study will consist of a screening day, a control week, a heat acclimation week, 3 heat stress test (HST) and meal-test (MT) days (t = -7, 0, and 8 (days)).
To avoid a confounding effect of seasonal thermal differences and achieve maximal methodological quality, the study will be performed in the shortest possible timeframe for each participant.
Given the seasonal fluctuations in NL, transitioning from April (~7oC) to June (~20oC), a crossover design is not applicable as a washout period of approximately 2 months would be needed and the measurements would likely take place in different climatic outdoor conditions.
In total, 12 healthy male and female participants will be included in the study.
During the no-intervention week (week 1), participants will be asked to continue their normal life at home, without being present at the university.
In addition, during week 1, participants will be asked to wear a temperature sensor on their clothing to measure the environment temperature they are exposed to at home.
Thereafter, on the intervention week (week 2), participants will be exposed to increasing elevated temperatures and undergo 30 min of low-to-moderate intensity cycling in the heated laboratory room for 7 days.
The temperature settings are derived from past heat waves in the Netherlands, ensuring a realistic representation.
The low exercise intensity is selected to be accessible to the majority of individuals within the target population.
The HST-MT will be conducted on the first visit after the screening to serve as baseline measurements.
The same tests will also be repeated before and after the heat acclimation week to determine the physiological response to increasing ambient temperatures.
All measurements will take place in the Metabolic Research Unit of Maastricht University (MRUM), the Netherlands.
Study Type
Interventional
Enrollment (Estimated)
12
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Sofia Pappa, M.Sc.
- Phone Number: +31433882507
- Email: sofia.pappa@maastrichtuniversity.nl
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
- Healthy males and females
- 60 to 80 years
- BMI 25-30 kg/m2
- Sedentary (<2h exercise/week)
Exclusion Criteria:
- Presence of chronic cardiovascular disease, as determined by medical history and physical examination
- Participating in a structured exercise program
- Taking hot baths/saunas regularly
- Travelled for a prolonged time to destinations with elevated temperatures the last 3 months
- Pre-existing T2DM
- Blood donation within a month of study initiation
- People with low haemoglobin concentration (males: Hb = 13.5-17.5 g/dL, females: Hb = 11.5-15.5 g/dL)
- Recent participation in biomedical study (less than 1 month)
- Using any medication that may influence glucose or lipid metabolism (beta-blockers, thyroid medications, stimulants, antidepressants, anticoagulants)
- Smoking or abuse of alcohol
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Heat acclimation
Passive heat exposure (29-35ºC; 6h/day for 7 days) in combination with 30min/day low-to-moderate intensity cycling.
|
Daily repeated heat exposure to assess the effects of combined passive and active heat acclimation
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Core temperature
Time Frame: 1 week of heat acclimation
|
thermophysiological parameters (ºC)
|
1 week of heat acclimation
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Skin temperature
Time Frame: 1 week of heat acclimation
|
thermophysiological parameters (ºC)
|
1 week of heat acclimation
|
Sweat rate
Time Frame: 1 week of heat acclimation
|
thermophysiological parameters (mL/min)
|
1 week of heat acclimation
|
Heart rate
Time Frame: 1 week of heat acclimation
|
cardiovascular parameters (bpm)
|
1 week of heat acclimation
|
Blood pressure
Time Frame: 1 week of heat acclimation
|
cardiovascular parameters (mmHg)
|
1 week of heat acclimation
|
Skin blood flow
Time Frame: 1 week of heat acclimation
|
cardiovascular parameters (mL/min)
|
1 week of heat acclimation
|
Energy expenditure
Time Frame: 1 week of heat acclimation
|
Metabolic parameters (kJ/min)
|
1 week of heat acclimation
|
Substrate oxidation
Time Frame: 1 week of heat acclimation
|
glucose and fat oxidation (umol/kg/min)
|
1 week of heat acclimation
|
Plasma metabolites
Time Frame: 1 week of heat acclimation
|
Plasma glucose, insulin, free-fatty acids, triglycerides, total cholesterol (mmol/L)
|
1 week of heat acclimation
|
Brain blood flow
Time Frame: 1 week of heat acclimation
|
additional cardiovascular parameters (mL/min)
|
1 week of heat acclimation
|
Flow-mediated dilation
Time Frame: 1 week of heat acclimation
|
endothelial function, (mm)
|
1 week of heat acclimation
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Guy Plasqui, Maastricht University
- Principal Investigator: Hannah Pallubinsky, Dr., Maastricht University
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Pallubinsky H, Schellen L, Kingma BRM, Dautzenberg B, van Baak MA, van Marken Lichtenbelt WD. Thermophysiological adaptations to passive mild heat acclimation. Temperature (Austin). 2017 Mar 10;4(2):176-186. doi: 10.1080/23328940.2017.1303562. eCollection 2017. Erratum In: Temperature (Austin). 2018 Apr 4;5(1):100.
- Pallubinsky H, Phielix E, Dautzenberg B, Schaart G, Connell NJ, de Wit-Verheggen V, Havekes B, van Baak MA, Schrauwen P, van Marken Lichtenbelt WD. Passive exposure to heat improves glucose metabolism in overweight humans. Acta Physiol (Oxf). 2020 Aug;229(4):e13488. doi: 10.1111/apha.13488. Epub 2020 Jun 1.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Estimated)
May 1, 2024
Primary Completion (Estimated)
December 1, 2024
Study Completion (Estimated)
December 1, 2024
Study Registration Dates
First Submitted
March 5, 2024
First Submitted That Met QC Criteria
April 24, 2024
First Posted (Actual)
April 29, 2024
Study Record Updates
Last Update Posted (Actual)
April 29, 2024
Last Update Submitted That Met QC Criteria
April 24, 2024
Last Verified
April 1, 2024
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- NL86367.068.24
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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