- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05294848
Increasing Psychological Resilience in Combat Soldiers Applying Advanced Eye-Tracking-Based Attention Bias Modification
Study Overview
Status
Conditions
Detailed Description
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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-
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Tel Aviv, Israel, 6997801
- Tel Aviv University
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Each soldier from the allocated cohort who gives written consent will be able to participate in the study.
Exclusion Criteria:
- Hebrew proficiency is insufficient to complete the study questionnaires.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Gaze-Contingent Feedback Training (toward threat)
In the task, 30 different matrices, each consisting of 16 faces, will be presented.
Each matrix includes 8 angry faces and 8 neutral, 8 women and 8 men, and the locations are counterbalanced between matrices.
The participants are asked to view the matrices in any way they choose, and the eye-tracking camera records their viewing location relative to the stimuli presented on the screen.
At the beginning of each training session, the soldier will choose to which music he would like to listen during the 12-minute session from a diverse list of music.
After calibrating the eye-tracker, the participant will be instructed to view matrices of faces as he chooses, as described above in the assessment task.
The music chosen by the participant will play only when he is looking at threatening faces and it will stop when he looks at neutral faces.
Thus, a change in viewing patterns is expected by implementing operant conditioning principles.
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Feedback according to participants' viewing patterns, in order to modify their attention toward threat stimuli.
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Active Comparator: RT-Based Attention Bias Modification (toward threat)
A dot-probe task of 160 trials. Trials begins with a fixation cross (+), on which the participant is asked to focus (500ms). Then two face stimuli (one angry one neutral) are presented above and below the fixation cross (500ms). After the stimuli disappear, a target probe (right- or left-pointing arrowhead) appears in place of one of the face stimuli. The participant is asked to indicate which target probe was presented using a predetermined key. The target probe will remain on the screen until response, after which a new trial will begin. Participants are instructed to identify the probe type as quickly and accurately as possible. In the training task, all of the target probes will appear in the threat location (angry face). Thus, over multiple trials, learning is expected to occurs such that the threatening face predicts the location of the target probe, thereby achieving the desired change in attention pattern. |
Attention training via repeated trials of a dot-probe task intended to direct attention toward threat stimuli using threat and neutral face stimuli.
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Placebo Comparator: Neutral Control
This condition is also based on the dot-probe task (see Active Comparator) with a fundamental difference.
In this task, only neutral faces will be displayed, and therefore, while participants are exposed to the same task parameters, there will be no attention training and there will be no exposure to threat stimuli.
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Dot-probe task using only neutral stimuli with no training toward threat
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Post-Combat PTSD Symptoms
Time Frame: Change from baseline Post-Combat PTSD Symptoms at approximately 1.5 years
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Score on on self-report questionnaire Posttraumatic stress disorder checklist for DSM-5 (PCL-5).
The total score, ranging from 0 to 80, reflects PTSD symptom severity, with higher scores representing greater severity.
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Change from baseline Post-Combat PTSD Symptoms at approximately 1.5 years
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Post-Combat General Anxiety
Time Frame: Change from baseline Post-Combat General Anxiety Symptoms at approximately 1.5 years
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Score on self-report questionnaire Generalized Anxiety Disorder questionnaire (GAD-7).
The total score, ranging from 0 to 21, reflects GAD symptom severity, with higher scores representing greater severity.
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Change from baseline Post-Combat General Anxiety Symptoms at approximately 1.5 years
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Post-Combat Depression
Time Frame: Change from baseline Post-Combat Depression Symptoms at approximately 1.5 years
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Score on self-report Patient Health Questionnaire 9 (PHQ-9).
The total score, ranging from 0-27, reflects severity of depressive symptoms, with higher scores representing greater severity
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Change from baseline Post-Combat Depression Symptoms at approximately 1.5 years
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Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Post-Training RT-based Attention Bias toward threat
Time Frame: Change from baseline Attention Bias within 6 months of baseline measurement
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Change in Attention Bias will be assessed with a response-time based dot-probe task.
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Change from baseline Attention Bias within 6 months of baseline measurement
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Post-Training Subjective Attention Bias toward threat
Time Frame: Change from baseline Attention Bias within 6 months of baseline measurement
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Change in Subjective Attention Bias will be assessed with a self-reported attention bias using the Attention Bias Questionnaire (ABQ).
The total score, ranging from 0 to 36, represents threat-related attention bias, with higher scores representing greater bias toward threat.
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Change from baseline Attention Bias within 6 months of baseline measurement
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Post-Training Eye-tracking Attention Bias toward threat
Time Frame: Change from baseline Attention Bias within 6 months of baseline measurement
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Change in Attention Bias will also be assessed with an eye-tracking task.
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Change from baseline Attention Bias within 6 months of baseline measurement
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Yair Bar-Haim, PhD, Tel Aviv University
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- TAU-GCFTresilience
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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