Stockholm Myocardial Infarction With Nonobstructive Coronaries Study 3

Stockholm Myocardial Infarction With Nonobstructive Coronaries Study 3 - Pilot Study of Prevalence of Coronary Microvascular Dysfunction in Myocardial Infarction With Nonobstructive Coronary Arteries

Sponsors

Lead Sponsor: Karolinska Institutet

Collaborator: Region Stockholm

Source Karolinska Institutet
Brief Summary

The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR investigation. Patient will be their own controls.

Overall Status Not yet recruiting
Start Date 2022-09-15
Completion Date 2024-03-31
Primary Completion Date 2023-12-31
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Diagnostic yield Through investigation completion, usually 2 hours
Secondary Outcome
Measure Time Frame
Prevalence of CMD in MINOCA Through investigation completion, usually 2 hours
Prevalence of CMD in different final MINOCA diagnoses Through investigation completion, usually 2 hours
Angina pectoris 3 Months
Enrollment 85
Condition
Intervention

Intervention Type: Diagnostic Test

Intervention Name: Cardiac magnetic resonance imaging to study coronary microvascular dysfunction

Description: Myocardial perfusion mapping will be investigated after administration of adenosine

Arm Group Label: Patients with MINOCA undergoing CMR

Eligibility

Criteria:

Inclusion Criteria: - a suspected diagnosis of MINOCA or takotsubo syndrome with coronary angiography without diameter stenosis ≥50% - age 35-80 years - reading and writing proficiency in Swedish Exclusion Criteria: - Claustrofobia - Arrythmia and/or pacemaker (atrial fibrillation and AV-block I- III) - Asthma or severe chronic obstructive lung disease - eGFR < 30 ml/min - spontaneous coronary artery dissection - acute pulmonary embolism - acute myocardial infarction type 2 - cardiomyopathy other than takotsubo syndrome - a previous myocardial infarction due to CAD

Gender:

All

Minimum Age:

35 Years

Maximum Age:

79 Years

Healthy Volunteers:

No

Overall Official
Last Name Role Affiliation
Per Tornvall, MD Principal Investigator Karolinska Instítutet
Overall Contact Contact information is only displayed when the study is recruiting subjects.
Verification Date

2022-06-01

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Karolinska Institutet

Investigator Full Name: Per Tornvall

Investigator Title: Professor

Has Expanded Access No
Condition Browse
Number Of Arms 1
Arm Group

Label: Patients with MINOCA undergoing CMR

Type: Other

Description: Patients will be their own controls

Acronym SMINC-3
Patient Data No
Study Design Info

Allocation: N/A

Intervention Model: Single Group Assignment

Intervention Model Description: Patients will be their own controls

Primary Purpose: Diagnostic

Masking: None (Open Label)

Masking Description: The investigators who will perform the evaluation of the CMR investigations will be blinded to all clinical data.

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