- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05507918
Effect of Pre-operative Oral Hydration on Post-operative Pain and Nausea in Adults Undergoing Tonsillectomy
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Common indications for adult tonsillectomy include tonsillar hypertrophy, obstructive sleep apnea, and chronic tonsillitis. Although there are many studies looking into how best to prevent and treat post-operative pain and nausea, there are very few that give recommendations to the patients pre-operatively. This study's aim is to evaluate if pre-operative oral hydration has an impact in reducing post-operative pain, nausea and vomiting after adult tonsillectomies. If pre-operative hydration can reduce the pain associated with the procedure, then this could also be an adjunct to help reduce the amount of narcotic pain medication that is required.
The goal of this study is to evaluate if the amount of pre-operative oral hydration can reduce the amount of pain and nausea/vomiting in patients undergoing adult tonsillectomies. This study will be measuring post-operative pain and nausea scores at several points after the adult tonsillectomy procedure for participants that have consumed different amounts of clear fluid in the 24 hours leading up to their nothing by mouth (NPO) status. Participants will be randomized to one of three categories of preoperative fluid: 0.5 - 1.5 Liters (L), 1.5 - 3 L, and 3 - 4.5 L, which will correlate to the low, medium and high fluid intake groups, respectively. Participants will be given a 1000 mL measuring water bottle that they can use to accurately record their fluid consumption in the 24 hours prior to their pre-operative NPO status. The fluid consumption that they record will include all liquids (i.e., water, flavored water, juice, coffee, tea, soda, milk, alcohol). They will be asked to keep a record of the volume of caffeinated beverage versus un-caffeinated beverages.
After surgery the participants will be given a form to record their pain and nausea scores. Participants will record their pain and nausea by using two separate 10-point scales at 7 different points after the procedure. These scores will be measured immediately after surgery, and at 4 hours, 8 hours, 24 hours, 72 hours, 5 days and 7 days postoperative. This form, along with a count of opioid medication used, will be retuned to the physician at the first post-operative follow-up visit.
Study Type
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Jake Sims, DO
- Phone Number: 248-888-2609
- Email: jake.sims@beaumont.org
Study Contact Backup
- Name: Bobbie Lewis, RN
- Phone Number: 248-551-5958
- Email: bobbie.lewis@beaumont.org
Study Locations
-
-
Michigan
-
Farmington Hills, Michigan, United States, 48336
- Recruiting
- Beaumont Hospital
-
Contact:
- Jake Sims, DO
- Phone Number: 248-888-2609
- Email: jake.sims@beaumont.org
-
Contact:
- Bobbie Lewis, RN
- Phone Number: 248-551-5958
- Email: bobbie.lewis@beaumont.org
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Adult undergoing primary tonsillectomy or any procedure which includes tonsillectomy as component at Beaumont Farmington Hills Hospital or Novi Surgery Center.
- Patients greater than or equal to 18 years of age
Exclusion Criteria:
- Patients < 18 years of age
- Decisionally impaired
- Adults with history of significant gastro-esophageal pathology (ie. gastric/duodenal ulcers, Barrett's esophagus, eosinophilic esophagitis)
- Patient undergoing tonsillectomy procedure due to previous or active peri-tonsillar abscess or for resection of cancer
- Allergy or contraindication to the use of acetaminophen or narcotic medications
- Pregnant
- Patients that have chronic disease states including chronic kidney disease, congestive heart failure, diabetes mellitus, diabetes insipidus, or chronic pain syndrome
- Patients that are on chronic pain medications, diuretics or steroids
- Patients that have history of significant nausea/vomiting associated with anesthesia
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Low fluid intake
0.5 L - 1.5 L fluid intake in the 24 hours prior to NPO status for surgery
|
Measured oral intake of fluids prior to tonsillectomy
Other Names:
|
Experimental: Medium fluid intake
1.5 L - 3 L fluid intake in the 24 hours prior to NPO status for surgery
|
Measured oral intake of fluids prior to tonsillectomy
Other Names:
|
Experimental: High fluid intake
3 L - 4.5 L fluid intake in the 24 hours prior to NPO status for surgery
|
Measured oral intake of fluids prior to tonsillectomy
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Pain 8 hours postoperative
Time Frame: 8 hours postoperative
|
Participant reported pain on a Likert scale from 0-10, where 0=no pain and 10= worst pain possible.
|
8 hours postoperative
|
Nausea 4 hours postoperative
Time Frame: 4 hours postoperative
|
Participant reported nausea on a Likert scale from 0-10, where 0=no nausea and 10 = worst nausea possible.
|
4 hours postoperative
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Pain postoperative
Time Frame: up to 7 days postoperative
|
Participant reported pain on a Likert scale from 0-10, where 0=no pain and 10= worst pain possible.
|
up to 7 days postoperative
|
Nausea postoperative
Time Frame: up to 7 days postoperative
|
Participant reported nausea on a Likert scale from 0-10, where 0=no nausea and 10 =
|
up to 7 days postoperative
|
Narcotic pain medication use immediately following surgery
Time Frame: 4 hours
|
Opioid pain medication administered in Post-Anesthesia Care Unit (PACU) in morphine equivalents
|
4 hours
|
Nausea medication use immediately following surgery
Time Frame: 4 hours
|
Oral anti-nausea medication administered in Post-Anesthesia Care Unit (PACU)
|
4 hours
|
Narcotic pain medication use after discharge
Time Frame: up to 14 days postoperative
|
Opioid pain medication used after discharge in morphine equivalents
|
up to 14 days postoperative
|
Nausea medication use after discharge
Time Frame: up to 14 days postoperative
|
Oral anti-nausea medication (4 mg zofran) used after discharge
|
up to 14 days postoperative
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Matthew Farrugia, DO, Beaumont Health - Farmington Hills
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2022-017
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Pain, Postoperative
-
Dr. Negrin University HospitalCompletedPostoperative Pain, Acute | Postoperative Pain, ChronicSpain
-
Atatürk Chest Diseases and Chest Surgery Training...RecruitingPostoperative Pain | Thoracotomy | Postoperative Pain, Acute | Postoperative Pain, ChronicTurkey
-
Ankara City Hospital BilkentRecruitingPostoperative Pain | Postoperative Pain, Acute | Postoperative Pain, Chronic | SternotomyTurkey
-
Atatürk Chest Diseases and Chest Surgery Training...RecruitingPostoperative Pain | Postoperative Pain, Acute | Postoperative Pain, Chronic | VATSTurkey
-
Aydin Adnan Menderes UniversityCompleted
-
Aydin Adnan Menderes UniversityCompletedAcute Postoperative Pain | Chronic Postoperative PainTurkey
-
Maimonides Medical CenterCompletedPOSTOPERATIVE PAINUnited States
-
University Hospital, AntwerpUnknown
-
VA Office of Research and DevelopmentRecruitingTotal Knee Arthroplasty (Postoperative Pain) | Total Hip Arthroplasty (Postoperative Pain)United States
-
VA Office of Research and DevelopmentCompletedTotal Knee Arthroplasty (Postoperative Pain) | Total Hip Arthroplasty(Postoperative Pain)United States
Clinical Trials on Oral water and clear liquids
-
Cedars-Sinai Medical CenterCompletedNausea/VomitingUnited States
-
Thomas Jefferson UniversityCompletedColonic DiseasesUnited States
-
Sheffield Teaching Hospitals NHS Foundation TrustHotel Dieu HospitalUnknownInflammatory Bowel Diseases | Celiac Disease | Capsule EndoscopyUnited Kingdom, Canada
-
University Health Network, TorontoNational Institute on Deafness and Other Communication Disorders (NIDCD)CompletedDeglutition Disorders | Oropharynx CancerCanada
-
The University of Texas Health Science Center,...Not yet recruitingPerioperative NutritionUnited States
-
Ain Shams UniversityNot yet recruitingPrevent Postopertive Nausea and Vomiting
-
University Health Network, TorontoNational Institute on Deafness and Other Communication Disorders (NIDCD)Completed
-
Wake Forest University Health SciencesCompletedCigarette Smoking | VapingUnited States
-
Boston Children's HospitalNot yet recruitingFasting | Gastric Emptying
-
Water Pik, Inc.Completed