Comparison of the Effect of MCFA and LCFA on Postprandial Appetite and Lipemia

August 27, 2023 updated by: Shatha Hammad, Assistant Professor, University of Jordan

Comparison of the Effect of Medium-Chain Fatty Acids and Long-Chain Fatty Acids on Postprandial Appetite and Lipemia

The main objective is to investigate if foods high in coconut oil (MCFA) or palm oil (LCFA) have different impacts on postprandial blood lipid levels and appetite via a visual analog scale (VAS).

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Postprandial lipemia has been recognized as a cardiovascular disease risk factor. The rate of postprandial triglyceride production and clearance in the blood, as well as the appetite, are influenced by the quality of the food consumed, such as the length of saturated fatty acids. The study will include 24 healthy adults ranging in age from 18 to 40 years old, of both sexes and it will be conducted at the University of Jordan. The study will involve two experimental test days, each separated by at least a week of washout interval, and each test day will last for 6 hours. All subjects will be randomly assigned to one of the experimental meals using computer-generated tables. Blood serum samples (2 mL) will be taken after an overnight fast and 2, 4, and 6 hours after eating the meals, and blood lipid profiles [total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG)] will be examined in a private lab. After that, participants will be allowed an ad libitum intake of standard meals. Each meal will be weighed before and after it is consumed, with the amount of food ingested being calculated.

Study Type

Interventional

Enrollment (Actual)

26

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Jordan
      • Amman, Jordan, 11942
        • The university of Jordan
      • Amman, Jordan
        • The university of Jordan

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 40 years (Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Age between 18-50 years
  • Males and females
  • Apparently healthy
  • Fasting triglyceride (TG) < 2.5 mmol/L or 222 mg/dl at the time of screening.
  • Body mass index (BMI) in normal range (18.5-24.9).
  • Stable weight for at least 3 months

Exclusion Criteria:

  • Consumption of lipid-lowering drugs or any medication that might affect appetite.
  • Consumption of any supplement that may affect lipid metabolism or appetite on a regular basis for the past month.
  • Regular consumption of two or more fish meals a week over the previous month.
  • A history of diabetes, gastrointestinal , liver disease, congestive heart failure, stroke, myocardial infarction, coronary artery bypass graft or established atherosclerotic disease.
  • Current smokers
  • Pregnant , breastfeeding, postmenopausal or suffer from polycystic ovary syndrome (PCOS)
  • Athlete
  • Being on a diet or lifestyle changes for the past month.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Coconut oil
The coconut oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits. Each participant will have ten minutes to consume biscuits with 250 ml of water. No other food will be consumed during the study period (6 hours). After that, participants will be allowed an ad libitum intake of standard meals. Each meal will be weighed before and after it is consumed, with the amount of food ingested being calculated. Then the participants will take the other treatment after a 1-week washout interval.
Dietary supplement: Coconut oil
Coconut oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits.
Active Comparator: Palm oil
The palm oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits. Each participant will have ten minutes to consume biscuits with 250 ml of water. No other food will be consumed during the study period (6 hours). After that, participants will be allowed an ad libitum intake of standard meals. Each meal will be weighed before and after it is consumed, with the amount of food ingested being calculated. Then the participants will take the other treatment after a 1-week washout interval.
Dietary supplement: Palm oil
Palm oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Anthropometric measurements ( Height)
Time Frame: baseline, pre-intervention, 1 day for each participant /during 3 months
Standing height, without footwear, will be taken using stadiometer to the nearest 5mm
baseline, pre-intervention, 1 day for each participant /during 3 months
Anthropometric measurements (Weight)
Time Frame: baseline, pre-intervention, 1 day for each participant /during 3 months
Bioelectrical impedance will be used to determine body weight
baseline, pre-intervention, 1 day for each participant /during 3 months
Anthropometric measurements (waist circumference)
Time Frame: baseline, pre-intervention, 1 day for each participant /during 3 months
Waist circumference (WC) will be measured at the midway between the lowest ribs and the iliac crest using a standard tape to the nearest 1 cm
baseline, pre-intervention, 1 day for each participant /during 3 months
Anthropometric measurements (percentage body fat)
Time Frame: baseline, pre-intervention,1 day for each participant /during 3 months
Bioelectrical impedance will be used to determine body composition
baseline, pre-intervention,1 day for each participant /during 3 months
Biochemical measurements (Total cholesterol (TC))
Time Frame: After the intervention / up to 3 months from collecting the samples
Up to 6 hours
After the intervention / up to 3 months from collecting the samples
Biochemical measurements (Low density lipoprotein cholesterol (LDL))
Time Frame: Up to 6 hours
Low-density lipoprotein cholesterol test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals
Up to 6 hours
Biochemical measurements ( High density lipoprotein cholesterol (HDL))
Time Frame: Up to 6 hours
High-density lipoprotein cholesterol test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals
Up to 6 hours
Biochemical measurements (Triglyceride (TG))
Time Frame: Up to 6 hours
Triglyceride test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals
Up to 6 hours
Dietary intake (3-days food record)
Time Frame: one day
Participants will be asked to fill out a food record to track changes in their (intake) appetite
one day

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Jordan

Investigators

  • Principal Investigator: Shatha S Hammad, PhD, The university of Jordan

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 1, 2022

Primary Completion (Actual)

October 1, 2022

Study Completion (Actual)

November 1, 2022

Study Registration Dates

First Submitted

June 13, 2022

First Submitted That Met QC Criteria

September 12, 2022

First Posted (Actual)

September 14, 2022

Study Record Updates

Last Update Posted (Actual)

August 29, 2023

Last Update Submitted That Met QC Criteria

August 27, 2023

Last Verified

August 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2022/6

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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