- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05562986
Impacts of Oral Irrigation in Orthodontic Patients
Clinical and Biochemical Evaluation Oral Irrigator Effectiveness in Patients Under Orthodontic Treatment
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The aim of this study is to compare the effectiveness of oral irrigator (OI) with interdental brush (IB) clinically and biochemically in orthodontic patients.
Thirty patients were randomly divided into two equal groups; patients using OI in addition to manuel brushing (OI-group), patients using IB in addition to manual brushing (IB-group). Study was planned as randomized, single-blind, parallel-design. Periodontal indexes were recorded clinically and interleukin (IL)-1β, IL-10, matrix metalloproteinase (MMP)-1, MMP-8 levels in gingival crevicular fluid were evaluated biochemically. After baseline examinations [Silness-Löe plaque index(PI), Löe-Silness gingival index(GI), probing pocket depth(PPD), clinical attachment level(CAL), bleeding on probing(BOP)], initial periodontal therapy was completed using full-mouth disinfection method. The data was collected in the baseline, 2nd, 4th and 8th weeks.
The hypothesis of our study is that oral irrigators may be effective in oral care of orthodontic patients because of the ease of use.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Samsun, Turkey, 55270
- Ondokuz Mayıs University, Faculty of Dentistry, Department of Periodontology
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Being over 12 years old.
- Having at least 20 permanent teeth with bands or brackets.
- Finished phase I periodontal treatment.
- Bleeding below 10% during probing.
- No pocket depth of more than 5 mm.
- Not receiving any treatment other than orthodontic treatment during the study.
- Absence of removable or fixed prosthetic restorations.
- Absence of any systemic disease (hepatic, renal, hematologic, cardiovascular).
- Agreeing not to use any non-study mouthwash throughout the study.
Exclusion Criteria:
- Performing poor cooperation.
- Having diseases associated with bacteriemia.
- Used antibiotics and anti-inflammatory drugs for any purpose for a long time.
- Having diabetes.
- Smoking habits.
- Having a physical or mental problem that affects manual dexterity.
- Using medication that could affect gingival health (such as dilantin, calcium channel blocker, cyclosporine, and anticoagulant).
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Oral irrigator group
Fifteen patients using toothbrush and oral irrigator (Aquapick, AQ-300, Aquapick Co, Ltd, Korea).
All patients were told to use Modified Bass method of tooth brushing technique.
PI, GI, PPD and CAL values were measured with William's probe (Hu-Fried, Chicago, IL, A.B.D) around the teeth.
All clinical parameters were evaluated on each of the six regions of the teeth (mesio-buccal, mid-buccal, disto-buccal, mesio-lingual, mid-lingual, disto-lingual).
GCF (gingival crevicular fluid) samples was collected one day after the clinical examination from buccal aspects of the mesial and distal surfaces at the interproximal sites for the evaluation of interleukin (IL)-1β, IL-10, matrix metalloproteinase (MMP)-1, MMP-8 mediators.
Following the initial clinical records, all patients were performed full mouth instrumentation and described oral hygiene procedure according to their groups.
|
Prior to GCF (gingival crevicular fluid) sampling, supragingival plaque was removed by sterile curets and, after air drying, the surfaces were isolated by cotton rolls.
Filter paper strips (periopaper, proflow Inc., Amityville, NewYork, USA) were placed in sulcus for 30s.
Care was taken not to avoid mechanical trauma and strips contaminated with blood or saliva were discarded.
The absorbed GCF volume was estimated by a calibrated instrument (periotron 8000, proflow Inc., Amityville, NY, USA).
Then, the strips were sealed into sterile tubes before freezing at -80 0C.
The readings were converted to an actual volume (μl) by reference to the standard curve.
|
Experimental: Interdental brush group
Fifteen patients using toothbrush and interdental brush.
All patients were told to use Modified Bass method of tooth brushing technique.
PI, GI, PPD and CAL values were measured with William's probe (Hu-Fried, Chicago, IL, A.B.D) around the teeth.
All clinical parameters were evaluated on each of the six regions of the teeth (mesio-buccal, mid-buccal, disto-buccal, mesio-lingual, mid-lingual, disto-lingual).
GCF (gingival crevicular fluid) samples was collected one day after the clinical examination from buccal aspects of the mesial and distal surfaces at the interproximal sites for the evaluation of interleukin (IL)-1β, IL-10, matrix metalloproteinase (MMP)-1, MMP-8 mediators.
Following the initial clinical records, all patients were performed full mouth instrumentation and described oral hygiene procedure according to their groups.
|
Prior to GCF (gingival crevicular fluid) sampling, supragingival plaque was removed by sterile curets and, after air drying, the surfaces were isolated by cotton rolls.
Filter paper strips (periopaper, proflow Inc., Amityville, NewYork, USA) were placed in sulcus for 30s.
Care was taken not to avoid mechanical trauma and strips contaminated with blood or saliva were discarded.
The absorbed GCF volume was estimated by a calibrated instrument (periotron 8000, proflow Inc., Amityville, NY, USA).
Then, the strips were sealed into sterile tubes before freezing at -80 0C.
The readings were converted to an actual volume (μl) by reference to the standard curve.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
GCF (gingival crevicular fluid) level of IL-1β as a marker of gingival inflammation
Time Frame: through study completion, an average of 1 year
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Elevated levels of IL-1β in GCF have been associated with the destructive changes that occur in the inflamed human gingiva, is a proinflammatory cytokine.
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through study completion, an average of 1 year
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GCF (gingival crevicular fluid) level of IL-10 as a marker of gingival inflammation
Time Frame: through study completion, an average of 1 year
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IL-10 plays an important role as a stop signal in suppressing the immune and inflammatory response by being released from periodontal tissues, thus trying to limit the spread and severity of the disease.
It is an anti-inflammatory cytokine.
It is reported that the level of GCF IL-10 is increased in inflamed areas.
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through study completion, an average of 1 year
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GCF (gingival crevicular fluid) level of MMP-1 as a marker of gingival inflammation
Time Frame: through study completion, an average of 1 year
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One of the MMPs, MMP-1, is generally expressed by fibroblasts, endothelial cells, keratinocytes, monocytes/macrophages, chondrocytes, and osteoblasts, and is a key regulator in connective tissue remodeling.
In addition to gingivitis, there is a significant increase in MMP-1 levels in the GCF during the active periods of periodontitis.
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through study completion, an average of 1 year
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GCF (gingival crevicular fluid) level of MMP-8 as a marker of gingival inflammation
Time Frame: through study completion, an average of 1 year
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High concentration of MMP-8 is associated with tissue destruction and severity of periodontal disease.
It is known to be secreted from inflammatory cells such as neutrophils and macrophages.
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through study completion, an average of 1 year
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Collaborators and Investigators
Sponsor
Investigators
- Study Director: Burcu OZKAN CETINKAYA, Prof, Ondokuzmayis University, Faculty of Dentistry, Department of Periodontology, Samsun, Turkey.
- Principal Investigator: Esma SAHIN, Dr, Erzurum Public Oral Health Center, Erzurum, Turkey.
- Study Chair: Bahattin AVCI, Prof, Ondokuzmayis University, Faculty of Medicine Department of Biochemistry, Samsun, Turkey.
- Study Chair: Selma ELEKDAG TURK, Prof, Ondokuzmayis University, Faculty of Dentistry, Department of Orthodontics, Samsun, Turkey.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- B.30.2.ODM.0.20.08/1352-1377
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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