- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05640128
Determination of Threshold Values of Aldosterone in HPLC-MS/MS, of Renin and of the Aldosterone / Renin Ratio for the Diagnosis of Primary Hyperaldosteronism (DAPS)
November 28, 2022 updated by: University Hospital, Caen
collaborative work within 2 hospitals at the CHU of Caen, at the CHRU of Lille, concerning the evaluation of the biological markers of primary hyperaldosteronism (PAH) with the dosage of aldosterone in LC -MS/MS, which is performed in both centers, with two different techniques.
The main objective is to define the range of Aldosterone concentrations in LC MS/MS, of renin in an automated method, in populations of healthy volunteers, essential hypertensives, and hypertensives with primary hyperaldosteronism.
, in order to establish a threshold for the screening of PAH by the RAR, and for the confirmation of PAH by a dynamic test with an Aldosterone threshold post salt load test.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
300
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Caen, France
- Recruiting
- CAEN University Hospital
-
Contact:
- Yves REZNIK
- Phone Number: +33 0231064585
- Email: reznik-y@chu-caen.fr
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 75 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Patients (18-75 years old) with moderate to severe hypertension, which justifies carrying out an etiological assessment in a hospital environment.
- Assessment carried out in compliance with the standardized measurement conditions of the RAR defined by the SFE consensus,
- Signature of a written consent by the patient
Exclusion Criteria:
- Patient on antihypertensive treatment other than alpha-blockers, calcium channel blockers or centrally acting antihypertensive
- Etiology of secondary hypertension other than PAH
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Aldosterone in HPLC-MS/MS,
Aldosterone in HPLC-MS/MS measurement
|
Aldosterone in HPLC-MS/MS
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Aldosterone values in LC-MS/MS (and renin) and RAR calculation and calculation of an RAR threshold for PAH screening which differentiates between essential hypertension and PAH.
Time Frame: baseline
|
Define the range of concentrations of Aldosterone in LC MS/MS, of renin in an automated immunological method with calculation of the RAR, in populations of healthy volunteers, essential hypertensives, and hypertensives with primary hyperaldosteronism , in order to establish a threshold for the detection of PAH by the RAR, and for the confirmation of PAH by a dynamic test of confirmation by Aldosterone.
|
baseline
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 2, 2018
Primary Completion (Anticipated)
January 2, 2023
Study Completion (Anticipated)
January 1, 2024
Study Registration Dates
First Submitted
November 28, 2022
First Submitted That Met QC Criteria
November 28, 2022
First Posted (Estimate)
December 7, 2022
Study Record Updates
Last Update Posted (Estimate)
December 7, 2022
Last Update Submitted That Met QC Criteria
November 28, 2022
Last Verified
November 1, 2022
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 17-209
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Hyperaldosteronism; Primary
-
Radboud University Medical CenterCompletedPrimary Aldosteronism | Primary HyperaldosteronismNetherlands
-
Haukeland University HospitalCompleted
-
University of Erlangen-Nürnberg Medical SchoolRecruitingPrimary Hyperaldosteronism | Electrolyte DisturbanceGermany
-
NovartisCompletedPrimary HyperaldosteronismFrance
-
University College, LondonUniversity College London Hospitals; Cambridge University Hospitals NHS Foundation... and other collaboratorsCompletedPrimary Hyperaldosteronism | Primary Hyperaldosteronism Due to Adrenal AdenomaUnited Kingdom
-
Assistance Publique - Hôpitaux de ParisCompletedHealthy | Essential Hypertension | Primary Hyperaldosteronism | Secondary HyperaldosteronismFrance
-
The Affiliated Nanjing Drum Tower Hospital of Nanjing...RecruitingPrimary Aldosteronism | Aldosterone-Producing Adenoma | Idiopathic HyperaldosteronismChina
-
Queen Mary University of LondonNational Institute for Health Research, United Kingdom; WBIC), Cambridge. University... and other collaboratorsUnknownPrimary Aldosteronism | HyperaldosteronismUnited Kingdom
-
Qifu LiFu Wai Hospital, Beijing, ChinaCompletedHyperaldosteronism; Primary | Hypertension SecondaryChina
-
Shanghai Jiao Tong University School of MedicineNot yet recruitingPrimary AldosteronismChina
Clinical Trials on Aldosterone in HPLC-MS/MS
-
Charite University, Berlin, GermanyCompletedLymphoma | Acute Lymphatic LeukemiaGermany
-
University of ManchesterBritish Heart Foundation; Manchester Academic Health Science Centre; Omron Healthcare...CompletedHypertension | Adherence, MedicationUnited Kingdom
-
Fondazione Policlinico Universitario Agostino Gemelli...CompletedBronchopulmonary Dysplasia; Retinopathy of PrematurityItaly
-
University of Illinois at ChicagoCongressionally Directed Medical Research ProgramsRecruitingMultiple Sclerosis | Major Depressive DisorderUnited States
-
University of Erlangen-Nürnberg Medical SchoolUnknownCoagulation Protein Disorders | Preterm Birth | Coagulation Disorder NeonatalGermany
-
University of Alabama at BirminghamCompletedMultiple SclerosisUnited States
-
Universitätsklinikum Hamburg-EppendorfSanofiCompletedMultiple Sclerosis | Clinically Isolated Syndrome | Multiple Sclerosis, Relapsing-RemittingGermany
-
University of Illinois at ChicagoEunice Kennedy Shriver National Institute of Child Health and Human Development...RecruitingMultiple SclerosisUnited States
-
University Hospital, Basel, SwitzerlandSwiss Multiple Sclerosis Society; Bangerter-Rhyner Stiftung; Center for Chronic...Active, not recruitingMultiple SclerosisSwitzerland