- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05748730
Clinical Trial for Integrated Care to Help At Risk Teen (iCHART) Intervention
The Center for Enhancing Triage and Utilization for Depression and Emergent Suicidality (ETUDES) in Pediatric Primary Care-iCHART RCT
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
iCHART is an intervention that includes 3 components previously studied in within the ETUDES Center including the:
- Safety planning app for suicidal youth which enables a primary care provider to streamline the gold standard of care for those with current suicidality symptoms through an app (instead of a paper based version);
- Mental Health Screener questionnaire that gathers additional mental health symptoms, treatment preferences, and family's readiness for treatment engagement to help primary care provider make a personalized, tailored treatment plan a suicidal youth is more likely to adhere to;
- Text Messages which aims to provide texts for 2-3 weeks to motivate youth to engage with the safety plan and recommended treatment following the patient visit.
Aim 1. Test the effectiveness of iCHART in reducing suicide-related events at 6 months, the primary outcome, and examine mediators and moderators of treatment response. The investigators hypothesize: 1) iCHART will reduce suicide-related events and its effects will be mediated by increases in mental health referrals made by pediatric providers (any designated staff member, doctor, nurse on the treatment team); treatment engagement (i.e., follow through with mental health referrals), and safety planning (as evident by EHR reviews); 2) Individual-, family-, and neighborhood-level risk and protective factors will moderate response; and 3) Examine a predictive algorithm to examine heterogeneity of treatment response.
Aim 2. Examine barriers, facilitators, and implementation outcomes specifically, acceptability, feasibility, appropriateness, and cost for the predictive algorithm and iCHART to inform future implementation efforts and promote health equity. Barriers and facilitators that span multiple levels of context (e.g., aspects of clinic workflows, provider beliefs and knowledge) are expected to be uncovered. Further, incorporating the predictive algorithm and iCHART in pediatric primary care will be viewed as feasible, acceptable, and appropriate by youth, caregivers, and providers across different racial and ethnic groups.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Brandie George-Milford, MA
- Phone Number: 412-246-5629
- Email: georgeba2@upmc.edu
Study Locations
-
-
Pennsylvania
-
McMurray, Pennsylvania, United States, 15317
- Recruiting
- Children's Community Pediatrics (CCP- Waterdam) of Children's Hospital of Pittsburgh UPMC
-
Contact:
- Dawn Gotkiewicz, MD
- Phone Number: 724-969-6970
- Email: gotkdx@upmc.edu
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Philadelphia, Pennsylvania, United States, 19104
- Not yet recruiting
- CHOP Primary Care, CHOP Campus
-
Contact:
- Kathleen Zsolway, DO
- Phone Number: 215-590-2178
- Email: zsolway@chop.edu
-
Philadelphia, Pennsylvania, United States, 19139
- Not yet recruiting
- CHOP Primary Care, Cobbs Creek
-
Contact:
- Andrea McGeary, MD
- Phone Number: 215-476-2223
- Email: mcgeary@chop.edu
-
Pittsburgh, Pennsylvania, United States, 15213
- Recruiting
- UPMC Center for Adolescent and Young Adult Health
-
Contact:
- Ana Radovic, MD
- Phone Number: 412-692-6677
- Email: Ana.Radovic@chp.edu
-
West Chester, Pennsylvania, United States, 19380
- Not yet recruiting
- CHOP Primary Care, West Chester
-
Contact:
- Wendy Wallace, DO
- Phone Number: 610-436-8611
- Email: wallace@chop.edu
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
YOUTH
- Youth will be age 12-18 and speak English.
- Youth will have current depression or suicidal behavior. Suicidal behavior for iCHART (N=900) is defined as past suicidal thoughts in the past two weeks as indicated by PHQ-9M item #9 ≥ 1, and/or past month suicidal thoughts, and/or prior history of attempt as indicated by items on the PHQ-9M; and 300 who screen positive for depression (PHQ-9M ≥ "11")
- 50% of the 300 youth with PHQ-9M ≥ "11" will also be positive for suicide risk as defined for iCHART.
CAREGIVERS/PARENTS
- Parents/caregivers of youth in the study must be at least 18 years old and their child must be willing to participate in the study. Caregivers/parents must be able to speak English. Parents are considered biological/adoptive parents or have court documentation that they can provide consent for research as a legal guardian of a youth. Only 1 parent/caregiver will be engaged in research, but in case 1 parent is unavailable, the other may be engaged (meaning it doesn't have to be the same parent participating in assessments/interviews throughout youth study participation).
Exclusion Criteria:
YOUTH
- Exclusion criteria include conditions that might impair their ability to effectively deploy ETUDES interventions, including:
- current manic or psychotic episode, presence of a life-threatening medical condition requiring immediate treatment, intellectual or developmental disability precluding comprehension of study procedure. The latter will will be assessed by parental report of placement in self-contained Special Education classes, EHR review, and during the consent/assent and/or baseline to determine if the participant is not understanding research procedures.
- Participants without access to a phone and/or tablet to interact with components of the intervention that require a phone will be excluded.
CAREGIVERS/PARENTS
- There are no specific exclusion criteria for caregivers and providers. However, as mentioned in the inclusion criteria, caregivers will be excluded if they are not the biological parent or court-appointed guardian of the youth being interviewed.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Health Services Research
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: iCHART
iCHART is an intervention that includes 3 components previously studied in within the ETUDES Center including a:
Participants will receive usual care at their pediatric primary care practice following screening including information, psychoeducation, and referral to a mental health treatment provider. |
The Safety Planning App will guide primary care providers or mental health clinicians in the use of an emotion regulation and safety planning app (BRITE) to be loaded on the phone of depressed and suicidal adolescents in order to improve depression and reduce the likelihood of a suicide attempt. The Mental Health Screener is a decision support tool to guide the primary care provider to make a referral that reflects patient clinical needs and patient and parental treatment preferences and perceived barriers to treatment. The Text Messages is a personalized text messaging intervention for patients and parents that targets engagement with the safety plan to increase the likelihood that a depressed or suicidal patient will maintain or initiate recommended services. Participants will receive usual care at their pediatric primary care practice following screening including information, psychoeducation, and referral to a mental health treatment provider. |
Active Comparator: Treatment As Usual (TAU)
Participants in this group will receive usual care from their primary care provider or mental health care provider which may include development of a paper safety plan.
|
Participants in this group will receive usual care from their primary care provider or mental health care provider which may include development of a paper safety plan.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Depression Severity
Time Frame: Baseline
|
Total scores from the Patient Health Questionnaire (PHQ-9-M) will be used to assess depression severity.
Total Score Depression Severity: 0-4 No or Minimal depression; 5-9 Mild depression; 10-14 Moderate depression; 15-19 Moderately severe depression; 20-27 Severe depression.
|
Baseline
|
Depression Severity
Time Frame: 1 Month Follow Up
|
Total scores from the Patient Health Questionnaire (PHQ-9-M) will be used to assess depression severity.
Total Score Depression Severity: 0-4 No or Minimal depression; 5-9 Mild depression; 10-14 Moderate depression; 15-19 Moderately severe depression; 20-27 Severe depression.
|
1 Month Follow Up
|
Depression Severity
Time Frame: 3 Month Follow Up
|
Total scores from the Patient Health Questionnaire (PHQ-9-M) will be used to assess depression severity.
Total Score Depression Severity: 0-4 No or Minimal depression; 5-9 Mild depression; 10-14 Moderate depression; 15-19 Moderately severe depression; 20-27 Severe depression.
|
3 Month Follow Up
|
Depression Severity
Time Frame: 6 Month Follow Up
|
Total scores from the Patient Health Questionnaire (PHQ-9-M) will be used to assess depression severity.
Total Score Depression Severity: 0-4 No or Minimal depression; 5-9 Mild depression; 10-14 Moderate depression; 15-19 Moderately severe depression; 20-27 Severe depression.
|
6 Month Follow Up
|
Depression Severity
Time Frame: 12 Month Follow Up
|
Total scores from the Patient Health Questionnaire (PHQ-9-M) will be used to assess depression severity.
Total Score Depression Severity: 0-4 No or Minimal depression; 5-9 Mild depression; 10-14 Moderate depression; 15-19 Moderately severe depression; 20-27 Severe depression.
|
12 Month Follow Up
|
Suicidal Ideation and Behavior
Time Frame: Baseline
|
Suicidal attempt and ideation will be measured through the Columbia Suicide Severity Rating Scale (C-SSRS). The following outcomes are C-SSRS categories: Wish to be Dead; Non-specific Active Suicidal Thoughts; Active Suicidal Ideation with Any Methods (Not Plan) without Intent to Act; Active Suicidal Ideation with Some Intent to Act, without Specific Plan; Active Suicidal Ideation with Specific Plan and Intent; Preparatory Acts or Behavior; Aborted Attempt; Interrupted Attempt; Actual Attempt (non-fatal); Completed Suicide. Self-injurious behavior without suicidal intent is also a C-SSRS outcome and has a binary response (yes/no). Suicidal Ideation Score is a numerical score derived from the C-SSRS categories. The maximum suicidal ideation category (1-5 on the CSSRS) present at the assessment. Assign a score of 0 if no ideation is present. |
Baseline
|
Suicidal Ideation and Behavior
Time Frame: 1 month follow up
|
Suicidal attempt and ideation will be measured through the Columbia Suicide Severity Rating Scale (C-SSRS). The following outcomes are C-SSRS categories: Wish to be Dead; Non-specific Active Suicidal Thoughts; Active Suicidal Ideation with Any Methods (Not Plan) without Intent to Act; Active Suicidal Ideation with Some Intent to Act, without Specific Plan; Active Suicidal Ideation with Specific Plan and Intent; Preparatory Acts or Behavior; Aborted Attempt; Interrupted Attempt; Actual Attempt (non-fatal); Completed Suicide. Self-injurious behavior without suicidal intent is also a C-SSRS outcome and has a binary response (yes/no). Suicidal Ideation Score is a numerical score derived from the C-SSRS categories. The maximum suicidal ideation category (1-5 on the CSSRS) present at the assessment. Assign a score of 0 if no ideation is present. |
1 month follow up
|
Suicidal Ideation and Behavior
Time Frame: 3 month follow up
|
Suicidal attempt and ideation will be measured through the Columbia Suicide Severity Rating Scale (C-SSRS). The following outcomes are C-SSRS categories: Wish to be Dead; Non-specific Active Suicidal Thoughts; Active Suicidal Ideation with Any Methods (Not Plan) without Intent to Act; Active Suicidal Ideation with Some Intent to Act, without Specific Plan; Active Suicidal Ideation with Specific Plan and Intent; Preparatory Acts or Behavior; Aborted Attempt; Interrupted Attempt; Actual Attempt (non-fatal); Completed Suicide. Self-injurious behavior without suicidal intent is also a C-SSRS outcome and has a binary response (yes/no). Suicidal Ideation Score is a numerical score derived from the C-SSRS categories. The maximum suicidal ideation category (1-5 on the CSSRS) present at the assessment. Assign a score of 0 if no ideation is present. |
3 month follow up
|
Suicidal Ideation and Behavior
Time Frame: 6 month follow up
|
Suicidal attempt and ideation will be measured through the Columbia Suicide Severity Rating Scale (C-SSRS). The following outcomes are C-SSRS categories: Wish to be Dead; Non-specific Active Suicidal Thoughts; Active Suicidal Ideation with Any Methods (Not Plan) without Intent to Act; Active Suicidal Ideation with Some Intent to Act, without Specific Plan; Active Suicidal Ideation with Specific Plan and Intent; Preparatory Acts or Behavior; Aborted Attempt; Interrupted Attempt; Actual Attempt (non-fatal); Completed Suicide. Self-injurious behavior without suicidal intent is also a C-SSRS outcome and has a binary response (yes/no). Suicidal Ideation Score is a numerical score derived from the C-SSRS categories. The maximum suicidal ideation category (1-5 on the CSSRS) present at the assessment. Assign a score of 0 if no ideation is present. |
6 month follow up
|
Suicidal Ideation and Behavior
Time Frame: 12 month follow up
|
Suicidal attempt and ideation will be measured through the Columbia Suicide Severity Rating Scale (C-SSRS). The following outcomes are C-SSRS categories: Wish to be Dead; Non-specific Active Suicidal Thoughts; Active Suicidal Ideation with Any Methods (Not Plan) without Intent to Act; Active Suicidal Ideation with Some Intent to Act, without Specific Plan; Active Suicidal Ideation with Specific Plan and Intent; Preparatory Acts or Behavior; Aborted Attempt; Interrupted Attempt; Actual Attempt (non-fatal); Completed Suicide. Self-injurious behavior without suicidal intent is also a C-SSRS outcome and has a binary response (yes/no). Suicidal Ideation Score is a numerical score derived from the C-SSRS categories. The maximum suicidal ideation category (1-5 on the CSSRS) present at the assessment. Assign a score of 0 if no ideation is present. |
12 month follow up
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Service Utilization
Time Frame: Baseline
|
Frequency and type of concurrent psychiatric services will be measured through the Child and Adolescent Services Assessment (CASA).The CASA is a semi-structured face-to-face interview.
The interview mixes close-ended questions that are often answered by "yes" or "no" with open-ended questions that allow elaboration.
The CASA is comprised of four sections: The Child Health Services Screen, The Detailed Child Services Form, Attitudes Toward Services for Children and Adolescents, and Family Demographic and Financial Information (in the parent version only).
|
Baseline
|
Service Utilization
Time Frame: 6 month follow up
|
Frequency and type of concurrent psychiatric services will be measured through the Child and Adolescent Services Assessment (CASA).Frequency and type of concurrent psychiatric services will be measured through the Child and Adolescent Services Assessment (CASA).The CASA is a semi-structured face-to-face interview.
The interview mixes close-ended questions that are often answered by "yes" or "no" with open-ended questions that allow elaboration.
The CASA is comprised of four sections: The Child Health Services Screen, The Detailed Child Services Form, Attitudes Toward Services for Children and Adolescents, and Family Demographic and Financial Information (in the parent version only).
|
6 month follow up
|
Service Utilization
Time Frame: 12 month follow up
|
Frequency and type of concurrent psychiatric services will be measured through the Child and Adolescent Services Assessment (CASA).Frequency and type of concurrent psychiatric services will be measured through the Child and Adolescent Services Assessment (CASA).The CASA is a semi-structured face-to-face interview.
The interview mixes close-ended questions that are often answered by "yes" or "no" with open-ended questions that allow elaboration.
The CASA is comprised of four sections: The Child Health Services Screen, The Detailed Child Services Form, Attitudes Toward Services for Children and Adolescents, and Family Demographic and Financial Information (in the parent version only).
|
12 month follow up
|
Application Utilization
Time Frame: Post-intervention-6 month follow up
|
Use of the technical components of interventions and web portals of iCHART including: the number and proportion of adolescents, parents, and providers who have engaged with the application over time
|
Post-intervention-6 month follow up
|
Intervention Acceptability (intervention liked by study population)
Time Frame: Post-intervention-6 month follow up
|
Acceptability of the iCHART intervention will be assessed through the 4 item Acceptability of Intervention Measure (AIM).
Scales can be created for by averaging responses.
Scale values range from 1 to 5. Higher scores indicate greater acceptability.
The items include questions to determine if intervention is appealing to, liked by, welcomed by, and approved by study population.
|
Post-intervention-6 month follow up
|
Intervention Usability
Time Frame: Post-intervention-6 month follow up
|
Usability of the iCHART intervention will be assessed through the Post System Satisfaction Usability Questionnaire (PSSUQ).
PSSUQ follows a 7-point Likert Scale (+ NA option).
The overall result is calculated by averaging the scores from the 7 points of the scale.
It also has 3 sub-scales, namely system usefulness, information quality, and interface quality.
The sub-scales provide a more detailed breakdown of different factors affecting the intervention.
PSSUQ score starts with 1 (strongly agree) and ends with 7 (strongly disagree).
The lower the score, the better the performance and satisfaction.
|
Post-intervention-6 month follow up
|
Intervention Feasibility (intervention is implementable in study population)
Time Frame: Post-intervention-6 month follow up
|
Feasibility of the iCHART intervention will be assessed through the 4 item Feasibility of Intervention Measure (FIM).
Scales can be created for by averaging responses.
Scale values range from 1 to 5. Higher scores indicate greater feasibility.
The items include questions to determine if intervention is easy to use and seems possible or doable to implement in study population.
|
Post-intervention-6 month follow up
|
Intervention Appropriateness (intervention fits or matches study population needs)
Time Frame: Post-intervention-6 month follow up
|
Intervention appropriateness of the iCHART intervention will be assessed through 4 item Intervention Appropriateness Measure (IAM).
Scales can be created for by averaging responses.
Scale values range from 1 to 5. Higher scores indicate greater appropriateness.
The items include questions to determine if intervention is a good match, fitting, suitable, or seems applicable to the study population.
|
Post-intervention-6 month follow up
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Stephanie Stepp, PhD, University of Pittsburgh
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- STUDY22020069
- P50MH115838 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Time Frame
IPD Sharing Access Criteria
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
- ICF
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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