- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05980130
Can Rumination-Focused Cognitive Behavioral Therapy Reduce the Risk of Cardio-vascular Disease? (RFCBT-I)
RFCBT I - Proof of Concept Study/Single Subject Design
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Objectives Objective #1: Determine whether RFCBT will impact blood pressure as a biomarker of cardiovascular health. The investigators hypothesize that RFCBT will lead to an improvement in blood pressure.
Objective #2: Determine whether RFCBT will impact stress biomarkers of cardiovascular health. The investigators hypothesize that RF-CBT will lead to an improvement of salivary cortisol.
Objective #3: Determine whether RFCBT will impact inflammatory biomarkers of cardiovascular health. The investigators hypothesize that RF-CBT will lead to an improvement of salivary C-Reactive Protein (h-CRP), interleukin (IL-6), and tumor necrosis factor-alpha (TNF-α).
Objective #4: Determine the acceptability of RFCBT for individuals with low income. While the investigators cannot predict the themes that will be generated, the information will have implications for the use of RFCBT with individuals with low income.
Study Design/Methodology The investigators will use a multiple baseline design - a type of Single Case Experimental Design (SCED) and collect survey, interview, and biological (blood pressure & saliva) data. Because of the study design, all participants will receive Rumination-Focused Cognitive Behavioral Training (RFCBT); the study is not blinded, and no non-intervention control group is necessary. As participants will be selected non-randomly, they will be randomly assigned to a group or in other words after how many weeks of baseline phase they will perceive RFCBT using the random number generator in the statistics package R. That is, 1/3rd of the participants will participate in 5 baseline waves of data collection, each one week apart, before starting RFCBT, another 1/3rd of participants will participate in 6 baseline waves before starting RFCBT, and the final 1/3rd of participants will participate in 6 baseline waves before starting RFCBT. Thus, all participants will participate in 5 to 7 weekly baseline waves. Next, each participant will participate with their trainer in up to 18 50-minute meetings of RFCBT. In this time, each participant will participate in 6 to 9 waves of training data collection (one wave of data collection every 2 RFCBT meetings). After completion of the training, each participant will be followed for another 10 weeks during which they participate in 5 waves of follow-up data collection (one wave of data collection every 2 weeks). Thus, each participant participates in 28 to 36 weeks in the study and takes part in 16 to 21 waves of data collection.
The investigators plan to recruit 27 adults with low income who have an elevated Response Style Questionnaire (RSQ)-Brooding score (>= 11), Patient Health Questionnaire (PHQ)-9 score (10-20), and blood pressure (systolic blood pressure [SBP]/ diastolic blood pressure [DBP]: >= 120 and/or 80) - that Have A Heart Clinic personnel administers regularly - and speak fluent English. There are no other exclusion criteria including any medical or psychological treatment. Patients who fulfill the above listed inclusion criteria are referred by Have A Heart Clinic personnel to the research team.
At each wave of data collection, the investigators will administer all the surveys listed in this report. All questions will be administered at each wave except for the questions about demographic information which will be asked during Baseline-1 only.
To measure blood pressure, the investigators will use an oscillometric measurement device. To do so, a blood pressure cuff will be placed about an inch above the elbow crease. For reliability purposes, blood pressure will be measured three-times with about 1 minute time between the measures.
To measure cortisol, h-CRP, IL-6, and TNF-α levels in saliva, participants will also be asked to provide saliva samples. Participants will be asked to avoid eating food or drinking caffeine for 3 hours prior to the saliva data collection in order to prepare for the saliva testing.
Once after the participants finish the RFCBT, they will be invited to take part in a semi-structured interview to explore their experiences in and acceptability of the training. The investigators intend to do these interviews with all participants who begin RFCBT (i.e., defined as completing at least one 50-minute meeting with their trainer), including those who drop out of the training, in-person, by phone, or a secure video platform.
The RFCBT exclusively addresses one possible mechanism underlying depression, rumination. In general, a participant and their trainer will identify when the participant ruminates in an unhelpful manner, what triggers the rumination, what function the rumination fulfills for the participant, and how the participant already does to stop ruminating. Building on this knowledge both together will change the environment to reduce the likelihood of the participant to ruminate, use consciously strategies to stop rumination when it occurs, and replace rumination by more helpful strategies. In the proposed single subject study, the participant and the trainer will meet in person or using a UofL approved video platform up to 18 times for 50-minutes.
Plan for Analysis of Results Following the best practice guidelines of the What Works Clearinghouse Standards for SCEDs, the investigators will examine consistency, intervention effect, immediacy, and auto-correlations for rumination, depressive symptoms, blood pressure, cortisol, h-CRP, IL-6, and TNF-α. The investigators will use Bayesian unknown changepoint models to estimate the parameters and model the treatment effect. A mixed effects model will be used to model the hierarchical structure of the data. The dependent variables are rumination, depressive symptoms, blood pressure, cortisol, h-CRP, IL-6, and TNF-α. The independent variable is phase. Bayesian estimation will be used to address the small sample nature of the data. For these statistical analyses the investigators will use R and "Just Another Gibbs Sampler" (JAGS). The investigators will conduct semi-structured interviews and analyze data using thematic analysis to generate themes associated with the data. The statistical program Dedoose will be utilized to facilitate this process.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Patrick Possel, Dr.rer.soc.
- Phone Number: 502-852-0623
- Email: patrick.possel@louisville.edu
Study Locations
-
-
Kentucky
-
Louisville, Kentucky, United States, 40202
- Recruiting
- Have a Heart clinic
-
Contact:
- Sherry Pancost
- Email: sherry.pancost@louisville.edu
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- RSQ-Brooding score: >= 11
- PHQ-9 score: 10-20
- SBP: >= 120 and/or DBP: >= 80)
- fluent in English
Exclusion Criteria:
- None besides the described inclusion criteria
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: RFCBT
This is a single subject design study.
Thus, all participants receive Rumination-Focused Cognitive Behavior Therapy
|
The RFCBT exclusively addresses one possible mechanism underlying depression, rumination.
In general, a participant and their therapist will identify when the participant ruminates in an unhelpful manner, what triggers the rumination, what function the rumination fulfills for the participant, and how the participant already does to stop ruminating.
Building on this knowledge both together will change the environment to reduce the likelihood of the participant to ruminate, use consciously strategies to stop rumination when it occurs, and replace rumination by more helpful strategies.
In the proposed single subject study, the participant and the therapist will meet in person or using a UofL approved video platform up to 18 times for 50-minutes.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Response Style Questionnaire
Time Frame: Baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
Baseline 1
|
Response Style Questionnaire
Time Frame: 1 week after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
1 week after baseline 1
|
Response Style Questionnaire
Time Frame: 2 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
2 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 3 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
3 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 4 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
4 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 5 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
5 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 6 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
6 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 7 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
7 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 9 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
9 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 11 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
11 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 13 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
13 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 15 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
15 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 17 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
17 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 19 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
19 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 21 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
21 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 23 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
23 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 25 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
25 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 27 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
27 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 29 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
29 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 31 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
31 weeks after baseline 1
|
Response Style Questionnaire
Time Frame: 33 weeks after baseline 1
|
sadness rumination, Score range: 5-20, higher score = more rumination
|
33 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: Baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
Baseline 1
|
Patient Health Questionnaire-9
Time Frame: 1 week after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
1 week after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 2 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
2 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 3 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
3 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 4 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
4 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 5 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
5 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 6 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
6 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 7 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
7 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 9 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
9 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 11 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
11 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 13 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
13 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 15 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
15 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 17 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
17 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 19 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
19 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 21 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
21 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 23 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
23 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 25 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
25 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 27 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
27 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 29 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
29 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 31 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
31 weeks after baseline 1
|
Patient Health Questionnaire-9
Time Frame: 33 weeks after baseline 1
|
depressive symptoms, Score range: 0-27, higher score = more depressive symptoms
|
33 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: Baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
Baseline 1
|
systolic blood pressure measures
Time Frame: 1 week after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
1 week after baseline 1
|
systolic blood pressure measures
Time Frame: 2 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
2 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 3 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
3 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 4 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
4 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 5 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
5 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 6 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
6 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 7 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
7 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 9 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
9 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 11 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
11 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 13 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
13 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 15 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
15 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 17 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
17 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 19 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
19 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 21 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
21 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 23 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
23 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 25 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
25 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 27 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
27 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 29 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
29 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 31 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
31 weeks after baseline 1
|
systolic blood pressure measures
Time Frame: 33 weeks after baseline 1
|
systolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
33 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: Baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
Baseline 1
|
diastolic blood pressure measures
Time Frame: 1 week after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
1 week after baseline 1
|
diastolic blood pressure measures
Time Frame: 2 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
2 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 3 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
3 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 4 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
4 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 5 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
5 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 6 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
6 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 7 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
7 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 9 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
9 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 11 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
11 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 13 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
13 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 15 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
15 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 17 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
17 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 19 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
19 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 21 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
21 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 23 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
23 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 25 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
25 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 27 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
27 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 29 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
29 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 31 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
31 weeks after baseline 1
|
diastolic blood pressure measures
Time Frame: 33 weeks after baseline 1
|
diastolic blood pressure; score range: 0-200+, higher score = higher blood pressure
|
33 weeks after baseline 1
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Patrick Possel, Dr.rer.soc., University of Louisville
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 23.0150
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Blood Pressure
-
DongGuk UniversityActive, not recruitingHypertension | Blood Pressure | Ambulatory Blood Pressure | Home Blood Pressure MeasurementKorea, Republic of
-
University of JordanCompletedBlood Pressure | Heart Rate | Airway PressureJordan
-
SE HealthCentre for Aging and Brain Health InnovationCompletedHypertension | Blood Pressure | Hypotension | High Blood Pressure | Low Blood PressureCanada
-
ROX Medical, Inc.CompletedHypertension | Blood Pressure, High | Blood Pressure, Resistant | Blood Pressure, UncontrolledUnited Kingdom, Netherlands, Belgium
-
Istituto Auxologico ItalianoRecruitingArterial Hypertension | Ambulatory Blood Pressure Monitoring | Blood Pressure Determination | Home Blood Pressure MonitoringItaly
-
Swansea UniversityNational Taiwan Normal UniversityRecruitingBlood PressureTaiwan, United Kingdom
-
Columbia UniversityNational Institute on Minority Health and Health Disparities (NIMHD)RecruitingBlood PressureUnited States
-
Yale UniversityPatient-Centered Outcomes Research InstituteRecruiting
-
University College, LondonNot yet recruiting
-
GE HealthcareRecruiting
Clinical Trials on Rumination-Focused Cognitive Behavior Therapy
-
University of Illinois at ChicagoCompleted
-
National Yang Ming UniversityBali Psychiatric CenterCompletedRandomized Controlled TrialTaiwan
-
Mental Health Services in the Capital Region, DenmarkRecruiting
-
Universidad Nacional Autonoma de MexicoCompletedPsychopathic Personality TraitMexico
-
University of UtahNational Institute of Mental Health (NIMH); University of ExeterRecruitingMood Disorders | Major Depressive DisorderUnited States
-
VU University of AmsterdamCompletedStress Disorders, Post-TraumaticNetherlands
-
West University of TimisoaraUniversity of ExeterUnknownDepression | Generalized Anxiety Disorder | Panic Disorder | Social Phobia | Dysthymic DisorderRomania
-
VU University of AmsterdamZonMw: The Netherlands Organisation for Health Research and DevelopmentCompletedDepression | Anxiety DisordersNetherlands
-
Laval UniversityUniversity of California, BerkeleyCompleted
-
Rutgers, The State University of New JerseyNational Institute of Mental Health (NIMH)CompletedSomatization DisorderUnited States