- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06008886
Effect of a Vegan Diet Versus a Mediterranean Diet. Assessing Health Outcomes (OMNIVEG)
Effect of a Vegan Diet Versus a Mediterrean Diet on Performance, Cardiorespiratory Fitness, Metabolic Health, Immune Status, and Environmental Impact in Healthy Adults
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
OMNIVEG is a controlled crossover trial. Initially, registered dietitians conducted an assessment of participants' lifestyles in a preliminary session. Qualified nutritionists then developed personalized diets for each participant in accordance with the recommendations of the International Society of Sports Nutrition (ISSN). These diets followed specific guidelines, including a daily intake of 3-5 g of carbohydrates per kilogram of body weight, 1.4-2.0 g of protein per kilogram of body weight, and 0.5-1.5 g of fat per kilogram of body weight.
Both the mediterranean diet and vegan diets prescribed to the participants were isocaloric, with similar distributions of macronutrients. The primary difference between the two interventions was the source of food: the vegan diet exclusively comprised plant-based foods, while the omnivorous diet included foods of both animal and plant sources. In the case of the omnivorous diet, 60% of the total protein intake was derived from animal sources (mainly from fish, white meat, low-fat dairy and eggs).
As part of the vegan diet, participants were instructed to take 1000 µg of cyanocobalamin (a form of vitamin B12) twice a week from Harrison Sport Nutrition, Granada, Spain. This supplementation aimed to ensure adequate vitamin B12 intake, which is essential for individuals following a vegan diet.
Throughout the study period, participants were advised to maintain their initial physical exercise frequency and volume to maintain consistency and avoid confounding variables. To ensure standardized measurements, all tests were conducted in the same laboratory, employing identical testing devices, and supervised by the same group of researchers. This approach aimed to minimize experimental variability and improve the reliability of the study's results.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
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Madrid, Spain, 28223
- Francisco de Vitoria University
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Men.
- Aged between 18-40 years.
- Physically active according to the recommendations of the World Health Organization (WHO).
- Body Mass Index (BMI) between 18.5-24.9 kg/m2.
- No tobacco use.
- No or low alcohol consumption and no orthopedic limitations that would interfere with the performance of the study tests.
Exclusion Criteria:
- Chronic diseases that impair athletic performance (cardiovascular, metabolic, gastrointestinal, respiratory) within the last six months.
- Musculoskeletal disease within the last six months.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Non-Randomized
- Interventional Model: Crossover Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Vegan diet
Vegan diet all foods included were of plant sources.
During the vegan diet, the participants took 1000 µg of cyanocobalamin twice a week (Harrison Sport Nutrition, Granada, Spain)
|
Normocaloric diet based solely on foods of plant sources.
|
Active Comparator: Mediterranean diet
In the case of the mediterranean diet, foods of animal sources were also included (animal protein accounted for 60% of total protein intake).
In this diet there was a predominance of plant foods; moderate to low consumption of fish, white meat, low-fat dairy and eggs; and very low consumption of red and processed meats, butter, full-fat dairy and sweets.
|
Diet with a predominance of plant foods fruits, vegetables, whole grains, nuts and legumes); moderate to low consumption of fish, white meat, low-fat dairy and eggs; and very low consumption of red and processed meats, butter, full-fat dairy and sweets.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cardiorespiratory fitness
Time Frame: 4 weeks
|
Cardiorespiratory fitness was measured using Maximal oxygen uptake (VO2max).
|
4 weeks
|
Metabolic health
Time Frame: 4 weeks
|
Metabolic health was measured using serum total cholesterol (TC), cholesterol-LDL (LDL-c) and colesterol-HDL (HDL-c)
|
4 weeks
|
Performance
Time Frame: 4 weeks
|
Performance was measured using FATmax (g/min).
|
4 weeks
|
Performance
Time Frame: 4 weeks
|
Performance was measured using countermovement (CMJ) (W) and squat jump (SJ).
|
4 weeks
|
Performance
Time Frame: 4 weeks
|
Performance was measured using squat jump (SJ) (W)
|
4 weeks
|
Environmental impact assessment
Time Frame: 4 weeks
|
Environmental impact was measured using Global-warming potential-100
|
4 weeks
|
Inmune status
Time Frame: 4 weeks
|
Inmune status was measured using lymphocyte levels (109/L )
|
4 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Performance
Time Frame: 4 weeks
|
Performance was measured using handgrip
|
4 weeks
|
Metabolic health
Time Frame: 4 weeks
|
Metabolic health was measured using systolic blood pressure (SBP) and diastolic blood pressure (DBP).
|
4 weeks
|
Inmune status
Time Frame: 4 weeks
|
Inmune status was measured using monocyte, eosinophils and neutrophils levels (10^9/L)
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4 weeks
|
Environmental impact assessment
Time Frame: 4 weeks
|
Environmental impact was measured using blue water footprint and land use.
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4 weeks
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Miguel López Moreno, Phd, Universidad Francisco de Vitoria
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 20/2023
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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