Acute Effect of Motor-Cognitive Training

The Acute Effects of Brain Activation and Functional Connectivity Following Motor-cognitive Training Using Functional MRI

Participants will complete a functional MRI to evaluate brain activation, functional connectivity, and behavioral performance immediately before and after a training program (approximately 30 minutes). The training program will comprise of integrate neuromuscular (agility, dynamic postural stability, shuffling, rapid acceleration/deceleration, plyometrics, lateral shuffle, and core stability) and cognitive (reaction time, processing speed, task switching, decision-making, and working memory) challenges.

Study Overview

• Status: Completed
• Conditions: Injury;Sports
• Intervention / Treatment: Other: Motor-Cognitive Training Program

• Study Type: Interventional
• Enrollment (Actual): 21
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Ke'La H Porter, MS; Phone Number: 859-323-9850; Email: kela.porter@uky.edu
• Study Contact Backup: Name: Matthew C Hoch, PhD; Email: matt.hoch@uky.edu

Study Locations

• United States
  • Kentucky
    • Lexington, Kentucky, United States, 40506
      • University of Kentucky
      • Contact: Ke'La Porter, MS; Phone Number: 859-323-9850; Email: kela.porter@uky.edu

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Physically active

Exclusion Criteria:

• Injury to the muscle or bone (upper extremity, lower extremity, or back) within the past 3 months
• Had musculoskeletal surgery or fracture (required open reduction internal fixation or within the last 12 months)
• Had a concussion or mild head injury within the last year
• Have been diagnosed with any kind of neurological, vestibular, or visual disturbance that impairs mobility
• Currently taking medications that affect the central nervous system
• Pregnant or suspicions of being pregnant
• Have metal fragments, pins, plates, or clips, shrapnel, body piercings that cannot be removed, have surgical implants or orthodontics that cannot be removed
• Have claustrophobia
• Have a history of cognitive impairment

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

Experimental: Physically active females; Healthy active females between 18 and 25

Other: Motor-Cognitive Training Program; The training will incorporate cognitive tasks which focus on reaction time, processing speed, working memory, cognitive flexibility, and inhibitory control using visual stimuli on a screen or through sensors which illuminate using LED lights. These cognitive tasks will be performed while also executing physical performance tasks that challenge static and dynamic postural stability, lateral movement, agility, and other movement patterns. The training session will last approximately 30 minutes and participants will complete up to 5 exercises

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in brain activation	During the task-based functional MRI scan the participant will complete a task-switching cognitive task, where participants have to identify two possible shapes (circle or square), in one of two possible colors (red or blue). They will respond using a trigger under their left and right foot. The level of brain activation during the task will be captured and reported.	2 hours, pre-training session and immediately post-training session
Change in functional connectivity	The participant will complete a resting-state functional MRI scan in which they will lay still in the scanner. No task is performed during this scan. Functional connectivity (functionally related regions of the brain that are co-activated) during the scan will be captured and reported.	2 hours, pre-training session and immediately post-training session
Change in reaction time	During the task-based functional MRI scan the participant will complete a task-switching cognitive task, where participants have to identify two possible shapes (circle or square), in one of two possible colors (red or blue). They will respond using a trigger under their left and right foot. The reaction time in milliseconds will be captured. The change in reaction time from pre to post training session will be reported.	2 hours, pre-training session and immediately post-training session
Change in accuracy	During the task-based functional MRI scan the participant will complete a task-switching cognitive task, where participants have to identify two possible shapes (circle or square), in one of two possible colors (red or blue). They will respond using a trigger under their left and right foot. The percent of correct responses (accuracy) will be captured. The change in accuracy from pre to post training session will be reported.	2 hours, pre-training session and immediately post-training session

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Demographic/Injury History Form	The demographic and injury history form is designed to capture: 1) information about the participant including age, height, weight, race, ethnicity, 2) information related to sports participation, and 3) information related to past injuries or medical conditions which are relevant to the study.	Once, pre-training
Defense Veterans Pain Rating Scale	The Defense Veterans Pain Rating Scale is a valid 5-item scale to assess pain magnitude and pain interference. This scale ranges from 0 to 10, 0 indicating no pain/interference and 10 indicating as bas as it could be/complete interference.	Once, pre-training
Modified Disablement In Physically Active Scale	16-item patient-reported outcome instrument that assesses physical and psychosocial status.This scale ranges from 0 to 4, 0 indicating no problem and 4 indicating severe.	Once, pre-training
NASA Physical Activity Survey	This survey asks individuals to self-report their general physical activity over the past week. This survey ranges from 0 to 10, 0 indicating sedentary and 10 indicating high physical activity.	Once, pre-training
Heart rate	Heart rate will be monitored with a noninvasive heart rate monitor that will be worn by the participant around the chest at the level of the xiphoid process. Resting heart rate will be collected prior to the start intervention then monitored and recorded throughout the training session.	35 minutes, during the training session
Average reaction time during the intervention	Average reaction time in milliseconds will be captured during the exercises via light sensors.	30 minutes, during the training session
Misses during the training session	The number of misses will be captured during the exercises via light sensors. A miss is considered when they deactivate the wrong sensor or don't deactivate the sensor quickly enough.	30 minutes, during the training session
Hits during the training session	The number of hits will be captured during the exercises via light sensors. A hit is considered when they deactivate the correct sensor.	30 minutes, during the training session
Number of errors during the training session	The number of errors will be captured during the exercises by visual observation. An error occurs when they do not complete they exercise correctly.	30 minutes, during the training session
Rate of perceived exertion	After each exercise the participant will be asked to rate their perceived exertion on a scale from 6 to 20, 6 indicating low perceived exertion and 20 indicating high perceived exertion	30 minutes, during the training session
Perceived cognitive difficulty	After each exercise the participant will be asked to rate their perceived cognitive difficulty on a scale from 1 to 10, 1 indicating low cognitive challenge and 10 indicating high cognitive challenge	30 minutes, during the training session

Collaborators and Investigators

• Sponsor: Ke'La H Porter
• Investigators: Principal Investigator: Ke'La H Porter, MS, University of Kentucky

Study record dates

Study Major Dates

• Study Start (Actual): September 17, 2023
• Primary Completion (Actual): February 5, 2024
• Study Completion (Actual): February 5, 2024

Study Registration Dates

• First Submitted: August 18, 2023
• First Submitted That Met QC Criteria: August 23, 2023
• First Posted (Actual): August 30, 2023

Study Record Updates

• Last Update Posted (Estimated): April 15, 2024
• Last Update Submitted That Met QC Criteria: April 11, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Keywords: cognition; physical performance; injury prevention; athletic training
• Additional Relevant MeSH Terms: Wounds and Injuries; Athletic Injuries
• Other Study ID Numbers: 88851

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No