- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06110923
A Clinical Trial to Compare and Evaluate Evaluate the Pharmacokinetics and Safety of CKD-846
A Randomized, Open-label and Parallel Study to Evaluate the Pharmacokinetics and Safety of CKD-846 in Healthy Male Subjects
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Estimated)
Phase
- Phase 1
Contacts and Locations
Study Contact
- Name: MInsoo Park, MD, PhD
- Phone Number: +82-2-2228-0401
- Email: MINSPARK@YUHS.AC
Study Locations
-
-
-
Seoul, Korea, Republic of
- Severance Hospital
-
Contact:
- MInsoo Park, MD, PhD
- Phone Number: +82-2-2228-0401
- Email: MINSPARK@YUHS.AC
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Healthy man aged between 19 to 55 at screening
- Weight ≥ 55kg
- Body mass index (BMI) of 18.5 to 27.0kg/m2
- Those who agree to contraception from the first Investigational Product (IP) dosing day till 6 months after the last dosing day and decide not to provide sperm during the participation of clinical trial
- Those who voluntarily decide to participate in paper and agree to comply with the cautions after fully understand the detailed description of this clinical trial
Exclusion Criteria:
- Those who have clinically significant disease or medical history of Hepatopathy, Renal, Neurological, Immunity, Respiratory, Endocrine, urinary, tumor or Psychical disorder
Those who have a history of clinically significant cardiovascular diseases such as myocardial infarction, angina pectoris, ventricular arrhythmia, heart failure, left ventricular outflow tract stenosis, stroke, and transient ischemic attack within 2 years prior to the first administration of the investigational drug
- Those who have had myocardial infarction within the last 90 days
- Those who have had unstable angina or angina that occurred during sexual intercourse
- Those who have had heart failure of New York Heart Association class 2 or higher in the past 6 months
- Those who have had a stroke within the last 6 months
Those with the following eye diseases
- Those with known genetic degenerative retinal diseases, including retinitis pigmentosa
- People who have lost vision in one eye due to non-arteritic anterior ischemic optic neuropathy
- Those with a past history of erection lasting more than 4 hours and priapism (erection accompanied by pain for more than 6 hours) while taking PDE5 inhibitors such as tadalafil
- Those who have a history of gastrointestinal surgery except simple appendectomy and hernia surgery which can interfere with drug absorption
- Persons with a history of clinically significant hypersensitivity to drugs or additives, including ingredients of clinical investigational drugs
- Those who have genetic problems such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption
A person who is judged to be unsuitable as a test subject in a screening test (screening items such as questionnaire, blood pressure, 12-lead ECG, physical examination, clinical laboratory test, etc.) conducted within 28 days before administration of the investigational drug
- Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) > 1.5 times higher than upper normal level
- Total bilirubin > 1.5 times higher than upper normal level
- Epidermal Growth Factor Receptor (eGFR) (estimated Glomerular Filtration Rate, which is calculated by MDRD) < 60 mL/min/1.73m2
- "Positive" or "Reactive" test result of Hepatitis B & C, HIV, rapid plasma reagin test (RPR) > 10.0 ng/mL
- Prostate specific antigen (PSA)
- Under 5 min resting condition, systolic blood pressure >150 mmHg or or <90 mmHg, diastolic blood pressure >100 mmHg or <50mmHg.
- Those who has a drug abuse history within one year or positive reaction on urine drug screening test.
Those who have taken the following drugs, excluding topical drugs without significant systemic absorption, within the relevant period and it is judged that the administered drugs may affect this study or affect the safety of subjects
- Over the counter (OTC), vitamins, health supplement within 7 days before the first dose of the investigational drug
- Ethical drug (ETC), herbal medicinal preparations within 14 days before the first dose of the investigational drug
- CYP3A4 inhibitors or CYP3A4 inducers within 30 days before the first dose of the investigational drug
- Depot injection or implantation within 30 days before the first dose of the investigational drug
Persons who must take the following drugs regularly and/or intermittently during the clinical trial period
- Nitrate preparations or NO donors
- Alpha blockers
- GC stimulators
- Those who continuously smoke excessively or consume caffeine or alcohol (cigarettes: >10 cigarettes/day, caffeine: >5 cups/day, alcohol: >210 g/week)
- A person who consumed food containing grapefruit within 7 days before the first administration of the investigational drug (e.g., a person who consumed more than 1L of grapefruit-containing beverages per day within 7 days before the first administration of the investigational drug)
- Persons who participated in another clinical trial (including bioequivalence test) and received an investigational drug within 180 days prior to the date of first administration of the investigational drug (in the case of biological products, the period may be extended considering the half-life)
- Those who donated whole blood within 60 days before the first date of administration and donated ingredients within 30 days
- Those who have received blood transfusion in 30 days
- Those who are deemed insufficient to participate in clinical study by investigators
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: A1 (Test group)
CKD-846 A, Single dose
|
once administration of Investigational Product
Other Names:
|
Experimental: R (Reference group)
D091, Multi dose
|
once administration of Investigational Product per day
Other Names:
|
Experimental: A2 (Test group)
CKD-846 A, Single dose
|
once administration of Investigational Product
Other Names:
|
Experimental: B2 (Test group)
CKD-846 B, Single dose
|
once administration of Investigational Product
Other Names:
|
Experimental: A3 or B3 (Test group)
CKD-846 A or B, Single dose
|
once administration of Investigational Product
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Plasma Concentration of CKD-846
Time Frame: Pre-dose, Post-dose 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 10, 24 hours (During the administration period)
|
Concentration of During the administration period
|
Pre-dose, Post-dose 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 10, 24 hours (During the administration period)
|
Concentration of D091
Time Frame: Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
Concentration of During the administration period
|
Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
CKD-846 of AUCinf
Time Frame: Pre-dose, Post-dose 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 10, 24 hours (During the administration period)
|
Area under the curve
|
Pre-dose, Post-dose 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 10, 24 hours (During the administration period)
|
CKD-846 of Tmax
Time Frame: Pre-dose, Post-dose 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 10, 24 hours (During the administration period)
|
Time to maximum plasma concentration
|
Pre-dose, Post-dose 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 10, 24 hours (During the administration period)
|
CKD-846 of t1/2
Time Frame: Pre-dose, Post-dose 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 10, 24 hours (During the administration period)
|
Terminal elimination half-life
|
Pre-dose, Post-dose 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 10, 24 hours (During the administration period)
|
CKD-846 of CL/F
Time Frame: Pre-dose, Post-dose 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 10, 24 hours (During the administration period)
|
Apparent clearance of drug in plasma
|
Pre-dose, Post-dose 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 10, 24 hours (During the administration period)
|
CKD-846 of Vd/F
Time Frame: Pre-dose, Post-dose 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 10, 24 hours (During the administration period)
|
Apparent volume of distribution
|
Pre-dose, Post-dose 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 10, 24 hours (During the administration period)
|
D091 of Cmax
Time Frame: Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
Maximum concentration of drug in plasma
|
Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
D091 of AUCt
Time Frame: Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
Area under the curve
|
Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
D091 of AUCinf
Time Frame: Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
Area under the curve
|
Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
D091 of Tmax
Time Frame: Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
Time to maximum plasma concentration at steady state
|
Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
D091 of t1/2
Time Frame: Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
Terminal elimination half-life
|
Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
D091 of CL/F
Time Frame: Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
Apparent clearance of drug in plasma
|
Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
D091 of Vd/F
Time Frame: Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
Apparent volume of distribution
|
Pre-dose, Post-dose 0.5, 1, 2, 4, 6, 10, 24, 48, 72, 96 hours (During the administration period)
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- A133_01PK2306
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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