- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06123702
Cannabidiol Effects on Fear Extinction in Social Phobia
April 17, 2024 updated by: Hartford Hospital
The investigators will randomly assign participants with social anxiety disorder to receive oral cannabidiol (CBD) or placebo.
Participants will undergo a fear conditioning and extinction trial, and the investigators will examine whether CBD increases the degree of fear reduction during extinction.
Study Overview
Status
Not yet recruiting
Conditions
Intervention / Treatment
Detailed Description
This will be a double-blind, randomized controlled trial of cannabidiol (CBD) vs. placebo for potentiating fear extinction in adult outpatients with social anxiety disorder (SAD).
After providing written informed consent and passing medical screening, participants will be assessed for SAD and other mental health concerns.
They will then engage in a fear conditioning paradigm in which an electrical stimulation is applied to the wrist that is aversive but not painful (at a level determined by each participant) paired with pictures of angry faces.
Following the fear conditioning paradigm, they will receive orally administered CBD or placebo.
They will then undergo a fear extinction phase in which the conditioned angry faces are shown repeatedly with no further electrical stimulus.
Fear toward the conditioned faces following extinction will be measured using galvanic skin response (GSR) and a visual analog scale of self-reported fear.
The investigators predict that CBD, compared to placebo, will result in lower GSR and self-reported fear ratings.
Study Type
Interventional
Enrollment (Estimated)
20
Phase
- Early Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: David Tolin, Ph.D.
- Phone Number: 860-545-7685
- Email: david.tolin@hhchealth.org
Study Locations
-
-
Connecticut
-
Hartford, Connecticut, United States, 06106
- Anxiety Disorders Center, Institute of Living
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- Age 18 and above
- Any gender
- Any race/ethnicity
- Primary diagnosis of SAD according to the DIAMOND
- At least moderate severity of SAD as evidenced by a DIAMOND severity rating of 4 (moderate) or higher
- Able to speak, read and write English (this is necessary because the study measures are only validated in English)
- Concurrent medications will be allowed so long as there is not a substantial risk of interaction with CBD
- Able/willing to consent to participate in study
Exclusion Criteria:
- <18 years old
- Active substance use disorder or mania according to the DIAMOND
- Severe risk of suicide or non-suicidal self-injury in the interviewer's judgment
- Current or past schizophrenia spectrum disorder according to the DIAMOND
- Developmental disability, including autism spectrum disorder, according to clinical interview
- History of organic brain illness or head injury with loss of consciousness > 5 minutes
- Liver function abnormalities as detected by liver functioning test
- History of allergic reaction to CBD according to clinical interview
- Unable or unwilling to abstain from CBD or tetrahydrocannabinol use for 24 hr prior to study participation
- Pregnancy or lack of adequate contraception
- Any clinical factors that would preclude the participant from providing informed consent or otherwise participating in the research, according to the interviewer's judgment
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: Placebo
Placebo capsules
|
Extinction of conditioned fear response
12 placebo capsules
|
Experimental: Cannabidiol
600 mg oral cannabidiol
|
Extinction of conditioned fear response
12 50-mg capsules
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Skin conductance
Time Frame: Single session (2.5 hours)
|
Galvanic skin responses to conditioned stimuli
|
Single session (2.5 hours)
|
Distress ratings
Time Frame: Single session (2.5 hours)
|
Subjective units of discomfort (0-100, 100 = maximum distress)
|
Single session (2.5 hours)
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: David Tolin, Ph.D., Hartford Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Estimated)
April 30, 2024
Primary Completion (Estimated)
December 31, 2024
Study Completion (Estimated)
December 31, 2024
Study Registration Dates
First Submitted
November 2, 2023
First Submitted That Met QC Criteria
November 7, 2023
First Posted (Actual)
November 9, 2023
Study Record Updates
Last Update Posted (Actual)
April 19, 2024
Last Update Submitted That Met QC Criteria
April 17, 2024
Last Verified
April 1, 2024
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- HHC-2023-0022
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Yes
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Social Anxiety Disorder
-
Aya Technologies LimitedCompletedSocial Anxiety | Social Anxiety Disorder | Social Anxiety Disorder (Social Phobia)United Kingdom
-
Tel Aviv UniversityCompletedSocial Anxiety | Social Anxiety Disorder | Social Anxiety Disorder (Social Phobia)Israel
-
University of BernUniversity of LuebeckActive, not recruitingSocial Anxiety Disorder (Social Phobia)Switzerland
-
Aya Technologies LimitedCompletedSocial Anxiety | Social Anxiety Disorder | Social Anxiety Disorder (Social Phobia)United Kingdom
-
Daniel LiebermanTerminatedAnxiety | Anxiety Disorder SocialUnited States
-
Weill Medical College of Cornell UniversityBrain & Behavior Research FoundationTerminatedSocial Anxiety | Social Anxiety Disorder | Social Anxiety Disorder of ChildhoodUnited States
-
Tufts UniversityCompletedSocial Anxiety | Social Anxiety Disorder | Social Anxiety Disorder of ChildhoodUnited States
-
Sumitomo Pharma America, Inc.BehaVR LLCCompletedSocial Anxiety Disorder (SAD)United States
-
Emory UniversityBristol-Myers SquibbCompleted
-
Florida International UniversityYale UniversityRecruitingSocial Anxiety Disorder of ChildhoodUnited States
Clinical Trials on Fear extinction
-
Uppsala UniversityCompletedHealthy SubjectsSweden
-
NYU Langone HealthNational Institute of Mental Health (NIMH)Recruiting
-
University of California, Los AngelesNational Heart, Lung, and Blood Institute (NHLBI)Recruiting
-
University of Wisconsin, MadisonCompleted
-
Duke UniversityWithdrawn
-
University of PittsburghNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)WithdrawnObesity | Overweight | Craving | Eating BehaviorUnited States
-
University of Texas at AustinUnknownAnxiety Disorders | Post Traumatic Stress Disorder | Panic Disorder | Social Phobia | PhobiaUnited States
-
Ruhr University of BochumRecruiting
-
Medical University of South CarolinaCompleted
-
Shenzhen Kangning HospitalRecruitingAlcohol Use DisorderChina