- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06183632
Lipid Characterisation of Plasma Microparticles in a Large Population of Healthy Donors (MicroLipids)
Extracellular vesicles (EVs) are membrane structures containing numerous mediators categorised according to their size and mode of production. Among them, microparticles (MPs) are EVs between 100 nm and 1 μm in size that are produced by budding at the plasma membrane of different cell types following different mechanisms of cell activation or death. MPs include a large pool of bioactive molecules, such as lipids, proteins or nucleic acids. This makes them important mediators of intercellular communication, increasingly recognised for their role in various biological processes such as inflammation, coagulation, immune response and tumour progression. Their ability to transmit molecular signals between cells may have implications for disease pathogenesis and cellular interactions in pathological microenvironments. These MPs therefore appear to be an innovative biomarker, potentially useful in the early management of disease, both in terms of diagnosis and as a therapeutic target.
The main techniques used to analyse these MPs include flow cytometry, which enables surface markers to be quantified and determined, and electron microscopy, which provides a direct view of their morphology and structure. Molecular biology, such as the quantitative PCR technique, is also an approach used by several teams, notably to search for RNA or DNA fragments involved in various biological processes. However, few studies have focused on the lipid composition of these MPs. Since MPs are membrane vesicles, they are a major lipid reservoir. In addition, lipids represent a significant population of molecules with extensive properties, whether in inflammation, cell proliferation, energy metabolism, etc.
The aim of this project is to develop a reliable and robust method for analysing plasma MP concentration, phenotype and lipid composition in a population of healthy volunteers. These parameters will subsequently provide a comparator for studying MPs in populations of patients suffering from cardiovascular and/or inflammatory diseases.
Study Overview
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Damien LELEU
- Phone Number: +33 0380669248
- Email: Damien.leleu@chu-dijon.fr
Study Locations
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-
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Dijon, France, 21000
- Recruiting
- CHU Dijon Bourgogne
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Contact:
- Damien LELEU
- Phone Number: +33 0380669248
- Email: Damien.leleu@chu-dijon.fr
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Person who has given his/her non-opposition
- All healthy volunteers are eligible to donate according to EFS criteria.
Exclusion Criteria:
- Person subject to a legal protection measure (curatorship, guardianship, etc)
- Pregnant, parturient or breast-feeding women
- Adults who are incapable or unable to give their consent
- Minors
- Person not eligible to donate according to EFS criteria.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Healthy donor
All healthy volunteers are eligible to donate according to EFS criteria.
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3 x 7mL EDTA blood tubes
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
microparticle concentration, phenotyping and lipid composition in a population of healthy subjects.
Time Frame: Through study completion, an average of 60 months
|
Through study completion, an average of 60 months
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- LELEU 2023
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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