- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06219616
Prediction of BK Virus Reactivation in Kidney Transplant Recipient
January 12, 2024 updated by: Suwasin Udomkarnjananun, King Chulalongkorn Memorial Hospital
Prediction of BK Virus Infection by Flow Cytometric Analysis of BK Virus-specific T Cell Responses in Kidney Transplant Recipients
There has been no effective predicting tool to accurately predict BKV reactivation after kidney transplantation.
The aim is to elucidate the use of flow cytometric analysis for both intracellular cytokines and surface activation markers for BKV-specific T cell response in kidney transplant recipients.
Study Overview
Status
Recruiting
Intervention / Treatment
Study Type
Interventional
Enrollment (Estimated)
60
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Suwasin Udomkarnjananun
- Phone Number: 6622564000
- Email: suwasin.u@gmail.com
Study Locations
-
-
-
Bangkok, Thailand, 10330
- Recruiting
- King Chulalongkorn Memorial Hospital
-
Contact:
- Suwasin Udomkarnjananun, M.D.
- Phone Number: 6622564000
- Email: suwasin.u@gmail.com
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Description
Inclusion criteria:
- New kidney transplantation cases (either living donor or deceased donor transplantation)
- Age ≥ 18 years old
- Agree to give a permission to blood sampling post-transplantation, and at the time of BK viremia.
Exclusion criteria:
- Pregnant
- Primary non-function of kidney allograft (i.e. kidney allograft never function).
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Screening
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: BKV immune monitoring
|
Blood will be drawn and investigated for BKV-specific T cell response.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
BKV-specific immune response
Time Frame: Day 30, Day 90 after transplantation before BK viremia
|
- To examine the capability of flow cytometry in predicting post-kidney transplant BKV infection, by the analyses of intracellular cytokines (interleukine-2) and surface activation markers (CD25) of T cells
|
Day 30, Day 90 after transplantation before BK viremia
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Dynamic change of BKV-specific immune response
Time Frame: Day 30, Day 90 after transplantation, irrespective ly to BK viremia
|
To examine the chonological change of BKV-specific immune response after transplantation, by the analyses of intracellular cytokines (interleukine-2) and surface activation markers (CD25) of T cells.
|
Day 30, Day 90 after transplantation, irrespective ly to BK viremia
|
BKV-specific immune response and immunosuppression regimen
Time Frame: Day 30, Day 90 after transplantation, in correlation to immunosuppressive medications
|
To examine the association between immunosuppressive regimen (tacrolimus, cyclosporine A, mycophenolate) and BKV-specific immune response after transplantation, by the analyses of intracellular cytokines (interleukine-2) and surface activation markers (CD25) of T cells.
|
Day 30, Day 90 after transplantation, in correlation to immunosuppressive medications
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
May 1, 2023
Primary Completion (Estimated)
April 30, 2025
Study Completion (Estimated)
October 31, 2025
Study Registration Dates
First Submitted
January 4, 2024
First Submitted That Met QC Criteria
January 12, 2024
First Posted (Estimated)
January 23, 2024
Study Record Updates
Last Update Posted (Estimated)
January 23, 2024
Last Update Submitted That Met QC Criteria
January 12, 2024
Last Verified
January 1, 2024
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- BKV-KCMH
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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