- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06227299
INTEGRAL Study: A Longitudinal Study of Surgeries and Lasers in Glaucoma
INTEGRAL Study: A Longitudinal Study of Surgeries and Lasers in Glaucoma: Long-term Results and Success Predictors Analysed From a Large-scale Retrospective and Prospective Glaucoma Register
Study Overview
Status
Conditions
Detailed Description
Glaucoma encompasses a group of chronic diseases characterized by progressive retinal nerve fibre loss and a concomitant pattern of visual field damage, eventually leading to blindness. To date, it is still considered the first cause of irreversible blindness worldwide. In recent years, treatment options for glaucoma have soared, and ophthalmologists can resort to a wide selection of drops, laser procedures and surgical techniques to reduce intraocular pressure, and slow the progression of the disease. The choice of the technique, however, often depends on personal preferences and it is still unclear if a specific technique is more efficient or safe, or if any patient-depending factors should guide the choice of treatment. The aim of this study is to create a large-scale register of all glaucomatous patients diagnosed, followed-up and treated in a large glaucoma-specialised tertiary centre, to analyse if any specific factor influence the progression of the disease or guide our treatment choice. This should lead to a better understanding of the disease itself and of the factors that should be considered when choosing the best treatment option for each patient, leading to safer, more efficient and more patient-centered care. This registry is thus of great importance for both patients and clinicians in the diagnosis and treatment of glaucoma.
The study is an observational analysis of patients' medical data recorded in a large-scale register, both retrospective and prospective.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Locations
-
-
Vaud
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Lausanne, Vaud, Switzerland, 1006
- Swiss Visio Montchoisi
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Diagnosis of glaucoma (open-angle, closed-angle, primary or secondary) or ocular hypertension (IOP > 24 mmHg, medicated or not)
- Patients who received treatment (medical, laser or surgical) at the Glaucoma Centre, Montchoisi Clinic and Swiss Visio Montchoisi
- Age: 18 years old or older
- Able and willing to provide informed written or verbal consent
Exclusion Criteria:
- Patients who are unable to understand the implications of their inclusion in the study or who are unable or unwilling to give informed consent
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Glaucoma patients
Patients with glaucoma
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
IOP changes
Time Frame: 2 months, 6 months, 12 months, 24 months, 36 months, 48 months, 60 months
|
intraocular pressure (IOP) values compared to baseline
|
2 months, 6 months, 12 months, 24 months, 36 months, 48 months, 60 months
|
Number of molecules
Time Frame: 2 months, 6 months, 12 months, 24 months, 36 months, 48 months, 60 months
|
• number of IOP-lowering medications required to maintain the IOP within therapeutic targets compared to baseline
|
2 months, 6 months, 12 months, 24 months, 36 months, 48 months, 60 months
|
Collaborators and Investigators
Investigators
- Principal Investigator: Kaweh Mansouri, MD, Swiss Glaucoma Research Foundation
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- INTEGRAL
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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