Bodyweight Interval Exercise in the Fed Versus Fasted State (BWE)

Bodyweight Interval Exercise in the Fed Versus Fasted State on Postprandial Glycemia, Appetite Perceptions and Fat Oxidation

The purpose of this study is to investigate the effects of a single session of at-home bodyweight interval exercise, performed in the fasted or fed state, on postprandial glycemic management, post-exercise fat oxidation, and overall perceptions of appetite in recreationally active females. This is a remote/online study and does not involve any visits to the laboratory.

Study Overview

• Status: Completed
• Conditions: Exercise
• Intervention / Treatment: Other: Fasted exercise; Other: Fed exercise

Detailed Description

Following the acquisition of informed consent via videoconferencing, eligibility to participate in the study will be determined using questionnaires. If inclusion criteria is met, participants will undergo virtual exercise familiarization by following a pre-recorded instructional video.

Eligible participants will be assigned, in a random order, to two metabolic trials at least 3 days apart in the follicular phase of the same menstrual cycle. These visits will be online with an investigator on videoconferencing. The two trials involve: 1) Exercise followed by breakfast; and 2) Breakfast followed by exercise.

Various outcomes will be measured throughout the metabolic trials including: blood sugar, fat oxidation and appetite. All research tools needed to acquire these methods will be delivered to participants' place of residence.

• Study Type: Interventional
• Enrollment (Actual): 12
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Canada
  • Ontario
    • Toronto, Ontario, Canada, M5S 2C9
      • Goldring Centre for High Performance Sport

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Females 18-35 years
• Recreationally active (complete <150 min of exercise 1-3 days per week) and not training for any specific sport
• Experiencing monthly menstrual periods (eumenorrheic)
• Are not currently on oral contraceptives, or are taking triphasic oral contraceptives
• Body mass index (BMI) ≥18.5 kg/m2 and ≤30 kg/m2
• Regular consumption of a breakfast meal (solid and liquid meals apply) most (≥ 4) days of the week
• Have a device compatible for use with study applications (e.g., smart phone)

Exclusion Criteria:

• Inability to safely perform physical activity as determined by the Get Active Questionnaire
• Not willing to consume the standardized test drink before and after exercise
• Sensitive to meal timing around exercise (e.g., gastrointestinal issues if exercise performed 10 min after the start of meal consumption or if a meal is consumed 5 min after exercise)
• Inability to adhere to pre-trial protocol guidelines (e.g., caffeine or alcohol restrictions)
• Physical limitations for bodyweight exercise
• Are on monophasic or biphasic oral contraceptives
• Regular tobacco or cannabis use (e.g., recreational and/or medical cannabis, cigarettes, e-cigarettes, vape pens, JUUL)
• Regular use of drugs that may alter metabolism (e.g., corticosteroids, nSAIDs)
• Diagnosed medical condition under the care of care of a physician (e.g., type 2 diabetes, cardiovascular disease) Currently enrolled in a course with Dr. Gillen

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Fasted Exercise; Exercise followed by breakfast	Other: Fasted exercise; Bodyweight interval exercise performed 5 minutes before the start of a mixed-macronutrient breakfast meal
Experimental: Fed Exercise; Breakfast followed by exercise	Other: Fed exercise; Bodyweight interval exercise performed 10 minutes after the start of consuming a mixed-macronutrient breakfast meal

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Average blood glucose concentration	Average blood glucose concentration during postprandial period	2 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Blood glucose concentration	Blood glucose concentration across postprandial period	2 hours
Blood glucose area under the curve	blood glucose area under the curve during postprandial period	2 hours
Peak blood glucose concentration	peak glucose across postprandial period	2 hours
Post-exercise fat oxidation	post-exercise fat oxidation measured as percent carbon dioxide	pre-exercise, immediately post-exercise, up to 3 hours post-exercise
Appetite Perceptions	Visual analog scales (0-100) will be used to determine perceptions of hunger, satisfaction, fullness, and prospective food consumption with higher scores denoting increased perceptions.	pre-exercise, immediately post-exercise, and 1, 2 and 3 hours post-exercise

Collaborators and Investigators

• Sponsor: University of Toronto
• Investigators: Principal Investigator: Jenna Gillen, PhD, University of Toronto

Study record dates

Study Major Dates

• Study Start (Actual): May 14, 2021
• Primary Completion (Actual): August 30, 2021
• Study Completion (Actual): August 30, 2021

Study Registration Dates

• First Submitted: January 14, 2024
• First Submitted That Met QC Criteria: January 25, 2024
• First Posted (Estimated): February 5, 2024

Study Record Updates

• Last Update Posted (Estimated): February 5, 2024
• Last Update Submitted That Met QC Criteria: January 25, 2024
• Last Verified: January 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Body Weight
• Other Study ID Numbers: 40799

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No