- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT02022904
Prostate Cancer Circulating Tumor Cells Based on Epithelial-Mesenchymal Transition Biology
28. juli 2015 opdateret af: Duke University
Development of a Novel Method to Detect Prostate Cancer Circulating Tumor Cells (CTCs) Based on Epithelial-mesenchymal Transition Biology
This is a minimal risk correlative clinical blood-drawing protocol.
The objective of this lead in pilot component is to determine whether Circulating Tumor Cells (CTC's) can be captured using the novel mesenchymal-marker based Near Infrared-Emissive Polymersomes (NIR-EPs), the PSMA-based NIR-EP, and the epithelial EpCAM-based NIR-EP.
If successful, the capture method will be evaluated further in the larger comparative study.
Studieoversigt
Status
Trukket tilbage
Betingelser
Intervention / Behandling
Undersøgelsestype
Interventionel
Fase
- Ikke anvendelig
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Han
Beskrivelse
Inclusion Criteria:
- histologically confirmed diagnosis of adenocarcinoma of the prostate
- Clinical or radiographic evidence of metastatic disease
Evidence of disease progression on androgen deprivation therapy (ADT) as evidenced by either of the following in the past:
- Two consecutive PSA levels greater than the PSA nadir achieved on ADT, separated by greater than one week
- Radiographic evidence of disease progression as defined by new bone scan lesions or soft tissue/visceral metastases >2 cm in diameter.
- Clinical progression as determined by the treating physician.
- Age greater than 18 years.
- Ability to understand and the willingness to sign a written informed consent document
Exclusion Criteria:
- History of intercurrent or past medical or psychiatric illness that would make participation in a blood drawing protocol difficult or not feasible at the discretion of the principal investigator or co-investigator(s)
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Tildeling: N/A
- Interventionel model: Enkelt gruppeopgave
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Eksperimentel: Metastatic prostate cancer
Near infrared (NIR) emissive nanotechnology
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Change in Non-detection rate of CTC's in men with CRPC
Tidsramme: at baseline, month 3, and progression (up to 18 months)
|
Non-detection rate of CTC's in men with CRPC will be measured at baseline, month 3, and at progression
|
at baseline, month 3, and progression (up to 18 months)
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Median number of CTC's detected by each capture method
Tidsramme: baseline, month 3, and progression (up to 18 months)
|
Calculate for each patient the number of CTC's detected by each capture method (novel and standard).
|
baseline, month 3, and progression (up to 18 months)
|
Change in median number of CTC's for each method
Tidsramme: at baseline, month 3, and progression (up to 18 months)
|
For each method, we will plot the change across time (baseline, cycle 3, and at progression) in the median number of CTC's for each method (novel and standard).
|
at baseline, month 3, and progression (up to 18 months)
|
Correlation of CTC enumeration with presenting clinical stage
Tidsramme: at baseline, month 3, and progression (up to 18 months)
|
at baseline, month 3, and progression (up to 18 months)
|
|
Correlation of CTC enumeration with sites of metastatic disease
Tidsramme: at baseline, month 3, and progression (up to 18 months)
|
at baseline, month 3, and progression (up to 18 months)
|
|
Correlation of CTC enumeration with Gleason sum
Tidsramme: at baseline, month 3, and progression (up to 18 months)
|
at baseline, month 3, and progression (up to 18 months)
|
|
Correlation of CTC enumeration with PSA kinetics
Tidsramme: at baseline, month 3, and progression (up to 18 months)
|
at baseline, month 3, and progression (up to 18 months)
|
|
Correlation of CTC enumeration with therapies
Tidsramme: at baseline, month 3, and progression (up to 18 months)
|
at baseline, month 3, and progression (up to 18 months)
|
|
Correlation of CTC enumeration with overall survival
Tidsramme: at baseline, month 3, and progression (up to 18 months)
|
at baseline, month 3, and progression (up to 18 months)
|
|
Correlation of CTC enumeration with progression-free survival
Tidsramme: at baseline, month 3, and progression (up to 18 months)
|
at baseline, month 3, and progression (up to 18 months)
|
|
Correlation of CTC enumeration with response to therapy
Tidsramme: at baseline, month 3, and progression (up to 18 months)
|
at baseline, month 3, and progression (up to 18 months)
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Andrew Armstrong, MD, Duke University
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. maj 2012
Primær færdiggørelse (Faktiske)
1. juni 2015
Studieafslutning (Faktiske)
1. juni 2015
Datoer for studieregistrering
Først indsendt
18. december 2013
Først indsendt, der opfyldte QC-kriterier
23. december 2013
Først opslået (Skøn)
30. december 2013
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
30. juli 2015
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
28. juli 2015
Sidst verificeret
1. juli 2015
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- Pro00037349
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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