Estrogen, Cytokines and Heart Failure in Women

Sponsoren

Hauptsponsor: National Heart, Lung, and Blood Institute (NHLBI)

Quelle National Heart, Lung, and Blood Institute (NHLBI)
Kurze Zusammenfassung

To determine the effects of estrogen therapy on postmenopausal women with congestive heart failure.

detaillierte Beschreibung

BACKGROUND:

Congestive heart failure (CHF) is a leading cause of morbidity, mortality, and hospitalization in women. The increase in mortality suggests that postmenopausal estrogen loss may alter the phenotypic expression of CHF. Because estrogen is a potent in vitro inhibitor of pro-inflammatory cytokines (e.g., TNFa, IL-1B, IL-6), which are re-expressed by the failing myocardium in patients with CHF and are related to an adverse prognosis, the study postulates that estrogen replacement will improve the outcome of postmenopausal women with CHF.

DESIGN NARRATIVE:

The randomized, double blind study was conducted in 166 postmenopausal women with congestive heart failure due to idiopathic (i.e.nonischemic) dilated cardiomyopathy and NYHA class II or III symptoms on either combined estrogen and progestin or placebo. Women maintained their then current congestive heart failure medications for six months. Three outcomes were measured: 1) Congestive heart failure severity/functional capacity quantified by maximum oxygen consumption during metabolic stress testing; 2) Left and right ventricular remodeling quantified by electron bean CT scan; 3) quality of life assessment by the Minnesota Living with Heart Failure and Kansas City cardiomyopathy questionnaires. In addition, measurements were made of pro-inflammatory markers, that had been demonstrated to be elevated in congestive heart failure to assess whether hormone replacement therapy reduced them.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Gesamtstatus Completed
Anfangsdatum December 2001
Fertigstellungstermin December 2003
Phase N/A
Studientyp Interventional
Bedingung
Intervention

Interventionsart: Drug

Interventionsname: Hormone Replacement Therapy

Teilnahmeberechtigung

Kriterien:

Postmenopausal women with NYHA Class II or Class III congestive heart failure due to idiopathic dilated cardiomyopathy.

Geschlecht: Female

Mindestalter: N/A

Maximales Alter: 100 Years

Gesunde Freiwillige: No

Insgesamt offiziell
Nachname Zugehörigkeit
Steven Reis University of Pittsburgh
Überprüfungsdatum

May 2005

Hat den Zugriff erweitert No
Bedingung Durchsuchen
Studiendesign Info

Zuweisung: Randomized

Maskierung: Double

Quelle: ClinicalTrials.gov