Mindfulness Based Stress Reduction for Older Adults With HIV Associated Neurocognitive Disorders

Inclusion Criteria:

• Age ≥ 55 years
• HIV-infected. For cases in which a participant has an undetectable plasma viral load and is not currently on cART, the participant will be asked to complete HIV antibody testing.
• Undetectable plasma viral load
• Symptomatic and sufficient neuropsychological testing abnormality to be rated as having impairment by consensus conference, but deficits in everyday functioning that would rate them as having no more than moderate disease. Participants with severe deficits consistent with dementia will not be randomized unless the study team agrees that deficits are mild enough to withstand rigors of MBSR.

Exclusion Criteria:

• Age < 55 years
• Failure to attend screening visits after two attempts and despite support offered
• Unwilling to participate in 8-week intervention
• Endorsing illicit drug use in the past 6 months
• Current or extensive previous mindfulness practitioner
• Detectable plasma HIV RNA (VL) in the previous 6 months or at enrollment. Individuals with VL <500 copies will be allowed to enroll if they have a history of UD VL with unchanged cART and show documentation of their past two clinical VL at UD levels (so called "viral blips").

• Any treatable condition that may impact cognition, including:

  • Neurosyphilis (cases with serum RPR positive will undergo lumbar puncture to evaluate)
  • Thyroid disorders (untreated)
  • B12 deficiency (untreated)
  • Cancer (requiring chemotherapy)
  • Neurological or psychiatric conditions where treatment options exist, such as multiple sclerosis, schizophrenia, uncontrolled epilepsy, recent and untreated major depression
  • HIV CNS escape (lumbar punctures will be completed in cases with clinical scenarios worrisome for escape as done clinically; e.g. more rapid course, new neurological symptoms, recent resistance in plasma)
• Language other than English as the main language of oral and written communication
• Inability to provide informed consent or assent with a legal surrogate to sign consent

• Major recent head injury, stroke, or major confounding cognitive factors including:

  • Cognitive impairment caused primarily by alcohol or substance use
  • Current active use of methamphetamine, cocaine or illicit use of narcotics (determined at screening and enrollment visits via clinical interview of substance abuse and dependence criteria)
  • MRI demonstrating current or past CNS lesions deemed to be clinically significant including that from past opportunistic infections but excluding white matter injury, as can be seen with cerebrovascular disease
  • Active brain infection, except for HIV
  • Significant systemic medical illness such as cancer requiring chemotherapy or end-stage cardiac or renal insufficiency
• Unstable psychiatric condition (e.g. active psychosis, suicidal ideation, homicidal ideation) or mental health or medical condition that, in the opinion of the investigators, will make it difficult for the potential participant to participate in the intervention
• Cases where the investigators feel the participant won't be able to complete the study