Denne siden ble automatisk oversatt og nøyaktigheten av oversettelsen er ikke garantert. Vennligst referer til engelsk versjon for en kildetekst.

Morphine After Radiofrequency Ablation of Painful Bone Metastases in Patients With Cancer (MEDOR)

25. mars 2021 oppdatert av: Institut Bergonié

Evaluation of the Effectiveness of the Radiofrequency Ablation for Reducing Refractory Pain From Bone Metastases

RATIONALE: Morphine may reduce pain in patients who have undergone radiofrequency ablation to remove bone metastases.

PURPOSE: This phase II trial is studying how well morphine works after radiofrequency ablation of painful bone metastases in patients with cancer.

Studieoversikt

Status

Fullført

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

OBJECTIVES:

Primary

  • Measure the efficacy of morphine sulfate at 8 weeks after radiofrequency ablation (RFA) of bone metastases.

Secondary

  • Assess minimum and average pain and analyze use of morphine sulfate before and after RFA.
  • Determine disease progression by CT scan of bone.
  • Evaluate the percentage of relief associated with RFA, specifically patient satisfaction, quality of life, anxiety, depression, and physical performance during RFA.
  • Assess complications and side effects related to RFA and the evolution of possible side effects associated with morphine sulfate therapy.

OUTLINE: This is a multicenter study.

Patients complete a pain questionnaire over 1 week before undergoing radiofrequency ablation (RFA). Patients also complete questionnaires about pain, physical performance, quality of life (QOL), and anxiety at baseline.

Bone metastases are removed by radiofrequency ablation (RFA). After surgery, patients receive acetaminophen and patient-controlled analgesic (PCA) morphine sulfate. PCA morphine sulfate continues with a dose increase of 50% bolus every 24 hours. Patients with maximum pain less than or equal to that at inclusion receive standard morphine sulfate therapy instead.

Data concerning the total dose of PCA morphine sulfate; minimum, average, and maximum pain intensity; side effects and complications of RFA; and total dose of morphine sulfate (or equivalent) is collected daily.

Pain is assessed at 4 and 8 weeks after RFA. Patients complete follow-up questionnaires about physical performance, QOL, and anxiety at 12 weeks. Patients also undergo a CT scan at 12 weeks.

Studietype

Intervensjonell

Registrering (Faktiske)

78

Fase

  • Fase 2

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

  • Frankrike
      • Bordeaux, Frankrike, 33076
        • Institute Bergonie

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år til 75 år (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Beskrivelse

DISEASE CHARACTERISTICS:

  • Histologically confirmed cancer

    • Primary or unknown origin

  • Painful bone metastases despite radiotherapy or symptomatic relapse into previously irradiated area with no possibility of repeating radiotherapy

    • Bone metastases may have been treated with bisphosphonates

    • Osteolytic bone or joint (lytic and condensed) confirmed by CT scan and meeting the following criteria:

      • Lesion size ≤ 5 cm

      • No more than 2 painful bone metastases

        • If 2 lesions are to be treated, distinct anatomical locations can be treated at the same time
      • Metastatic bone lesions of the pelvis, sacrum (in absence of canal involvement), ribs, or long bones allowed
    • Pain located at the tumor or in the area
  • Maximum pain in the last 24 hours > 4 points (numerical scale to 11 points)

PATIENT CHARACTERISTICS:

  • Life expectancy > 3 months
  • Platelet count > 50,000/μL
  • Prothrombin < 50%
  • Activated cephalin time ≤ 1.5 times normal
  • Not pregnant
  • Fertile patients must use effective contraception
  • No geographical, social, or psychiatric reason that would preclude follow up

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • At least 4 weeks since prior radiotherapy
  • At least 3 weeks since prior chemotherapy or bisphosphonates
  • At least 1 week since beginning new painkiller therapy or anticoagulation treatment
  • More than 30 days since participation in another drug study
  • More than 30 days since prior surgery

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Støttende omsorg
  • Tildeling: N/A
  • Intervensjonsmodell: Enkeltgruppeoppdrag
  • Masking: Ingen (Open Label)

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Eksperimentell: Patient who has undergone radiofrequency ablation of bone metastases
Patient who has undergone radiofrequency ablation of bone metastases, localized, causing pain refractory to radiotherapy or not accessible to new irradiation, biphosphonates and well-conducted morphine analgesic treatment.
Legemiddel: Acetaminophen
Intravenous administration of paracetamol (4 g / 24h) and patient-controlled analgesia (PCA).
Andre navn:
  • Paracet
Legemiddel: Morphine Sulfate
Patient-controlled analgesia (PCA), allowing morphine consumption to be titrated to the patient's needs and thus allowing morphine doses to be adapted to an increase in pain in the patient's post-operative period or a rapid analgesic effect of radiofrequency.
Andre navn:
  • Oral morphine equivalent
Annen: Questionnaire administration

Pain notebook will allow the patient to describe the pain specific to the metastasis concerned, containing information on :

  • The intensity of the minimum, average and maximum pain of the last 24 months. hours as well as the intensity of the pain of the moment according to a scale 11-point digital,
  • the background morphine analgesic treatment during the last 24 hours,
  • the morphine analgesic treatment taken during painful attacks,
  • the possible undesirable effects of morphine treatment.
  • the morphinic, non-morphinic and co-antalgic treatment is noted, as well as that the total dose of oral morphine or oral morphine equivalent
Fremgangsmåte: Quality-of-life assessment
Patients' quality of life will be assessed using the quality of life questionnaire EORTC QLQ-C30 at inclusion in the study and at 8 weeks after radiofrequency. ablation.
Fremgangsmåte: Radiofrequency ablation

Recent technique of thermal destruction of tumors.

This technique consists of inserting an electrode needle into the tumour under X-ray or ultrasound guidance or intraoperatively under laparoscopy for example. This needle carries a current or a light wave depending on the characteristics of the generator to which it is connected (radiofrequency, laser).

Radio frequencies are radiation non-ionising electromagnets. In this context of tissue ablathermia wavelengths ranging from 400kHz to 500kHz.

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Percentage of Participants With Maximum Pain Level Decreased by ≥ 2 Points at 2 Months After Radiofrequency Ablation (RFA)
Tidsramme: 2 months after radiofrequency ablation (RFA)

Difference in maximum pain scores between inclusion and 2 months after radiofrequency ablation (RFA) according to an 11-point numerical scale

Rate of patients with a decrease of two or more points in their most intense pain, 2 months after the radiofrequency ablation.

This rate is calculated for the evaluable population for the principal outcome measure.

This rate is equal to the ratio of the number of patients with a decrease of two or more points in their maximum pain divided by the size of the evaluable population.

The response rate considered acceptable is 50%, above this threshold the treatment will be considered potentially effective and may be proposed in phase III.
2 months after radiofrequency ablation (RFA)

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Difference in Maximum Pain Scores Between Inclusion and 2 Months After Radiofrequency Ablation
Tidsramme: Inclusion and 2 months after radiofrequency ablation (RFA)

Difference in maximum pain scores between inclusion and 2 months after radiofrequency ablation (RFA) according to a discrete 11-points numerical scale.

Increased/decreased pain is considered as a variation of at least one point on the numerical scale.

If 25 patients or more are observed with pain reduction of 2 or more points, then the treatment will be considered potentially effective.
Inclusion and 2 months after radiofrequency ablation (RFA)
Intensity of Pain (Minimum, Average, Maximum)
Tidsramme: First algology assessment at pre-selection visit

According to a discrete 11-points numerical scale which ranges from 0 (low pain) to 11 (intense pain), intensity of pain (Minimum, Average, Maximum) has been evaluated at different time point between pre-selection and up to 3 months after radiofrequency.

Assessment of intensity of pain has been done in this order at:

  • Pre-selection visit: First algology assessment within a week (± 3 days) after the radiology consultation,
  • Inclusion visit: Second algology assessment (One week after the first algology assessment)
  • J-1: one day before radiofrequency
  • J+1: One day after radiofrequency
  • Discharge from hospital
  • 7 days after discharge from hospital
  • 1 month after radiofrequency
  • 2 months after radiofrequency
  • 3 months after radiofrequency

Here, are presented only data collected at the pre-selection visit.
First algology assessment at pre-selection visit
Intensity of Pain (Minimum, Average, Maximum)
Tidsramme: Second algology assessment at inclusion visit

According to a discrete 11-points numerical scale which ranges from 0 (low pain) to 11 (intense pain), intensity of pain (Minimum, Average, Maximum) has been evaluated at different time point between pre-selection and up to 3 months after radiofrequency.

Assessment of intensity of pain has been done in this order at:

  • Pre-selection visit: First algology assessment within a week (± 3 days) after the radiology consultation,
  • Inclusion visit: Second algology assessment (One week after the first algology assessment)
  • J-1: one day before radiofrequency
  • J+1: One day after radiofrequency
  • Discharge from hospital
  • 7 days after discharge from hospital
  • 1 month after radiofrequency
  • 2 months after radiofrequency
  • 3 months after radiofrequency

Here, are presented only data collected at the inclusion visit.
Second algology assessment at inclusion visit
Intensity of Pain (Minimum, Average, Maximum)
Tidsramme: Algology assessment one day before radiofrequency (J-1)

According to a discrete 11-points numerical scale which ranges from 0 (low pain) to 11 (intense pain), intensity of pain (Minimum, Average, Maximum) has been evaluated at different time point between pre-selection and up to 3 months after radiofrequency.

Assessment of intensity of pain has been done in this order at:

  • Pre-selection visit: First algology assessment within a week (± 3 days) after the radiology consultation,
  • Inclusion visit: Second algology assessment (One week after the first algology assessment)
  • J-1: one day before radiofrequency
  • J+1: One day after radiofrequency
  • Discharge from hospital
  • 7 days after discharge from hospital
  • 1 month after radiofrequency
  • 2 months after radiofrequency
  • 3 months after radiofrequency

Here, are presented only data collected one day before radiofrequency (J-1).
Algology assessment one day before radiofrequency (J-1)
Intensity of Pain (Minimum, Average, Maximum)
Tidsramme: Algology assessment one day after radiofrequency: J+1

According to a discrete 11-points numerical scale which ranges from 0 (low pain) to 11 (intense pain), intensity of pain (Minimum, Average, Maximum) has been evaluated at different time point between pre-selection and up to 3 months after radiofrequency.

Assessment of intensity of pain has been done in this order at:

  • Pre-selection visit: First algology assessment within a week (± 3 days) after the radiology consultation,
  • Inclusion visit: Second algology assessment (One week after the first algology assessment)
  • J-1: one day before radiofrequency
  • J+1: One day after radiofrequency
  • Discharge from hospital
  • 7 days after discharge from hospital
  • 1 month after radiofrequency
  • 2 months after radiofrequency
  • 3 months after radiofrequency

Here, are presented only data collected one day after radiofrequency (J+1).
Algology assessment one day after radiofrequency: J+1
Intensity of Pain (Minimum, Average, Maximum)
Tidsramme: Algology assessment at the discharge from hospital visit

According to a discrete 11-points numerical scale which ranges from 0 (low pain) to 11 (intense pain), intensity of pain (Minimum, Average, Maximum) has been evaluated at different time point between pre-selection and up to 3 months after radiofrequency.

Assessment of intensity of pain has been done in this order at:

  • Pre-selection visit: First algology assessment within a week (± 3 days) after the radiology consultation,
  • Inclusion visit: Second algology assessment (One week after the first algology assessment)
  • J-1: one day before radiofrequency
  • J+1: One day after radiofrequency
  • Discharge from hospital
  • 7 days after discharge from hospital
  • 1 month after radiofrequency
  • 2 months after radiofrequency
  • 3 months after radiofrequency

Here, are presented only data collected at the discharge from hospital visit.
Algology assessment at the discharge from hospital visit
Intensity of Pain (Minimum, Average, Maximum)
Tidsramme: Algology assessment 7 days after discharge from hospital

According to a discrete 11-points numerical scale which ranges from 0 (low pain) to 11 (intense pain), intensity of pain (Minimum, Average, Maximum) has been evaluated at different time point between pre-selection and up to 3 months after radiofrequency.

Assessment of intensity of pain has been done in this order at:

  • Pre-selection visit: First algology assessment within a week (± 3 days) after the radiology consultation,
  • Inclusion visit: Second algology assessment (One week after the first algology assessment)
  • J-1: one day before radiofrequency
  • J+1: One day after radiofrequency
  • Discharge from hospital
  • 7 days after discharge from hospital
  • 1 month after radiofrequency
  • 2 months after radiofrequency
  • 3 months after radiofrequency

Here, are presented only data collected 7 days after discharge from hospital.
Algology assessment 7 days after discharge from hospital
Intensity of Pain (Minimum, Average, Maximum)
Tidsramme: Algology assessment 1 month after radiofrequency

According to a discrete 11-points numerical scale which ranges from 0 (low pain) to 11 (intense pain), intensity of pain (Minimum, Average, Maximum) has been evaluated at different time point between pre-selection and up to 3 months after radiofrequency.

Assessment of intensity of pain has been done in this order at:

  • Pre-selection visit: First algology assessment within a week (± 3 days) after the radiology consultation,
  • Inclusion visit: Second algology assessment (One week after the first algology assessment)
  • J-1: one day before radiofrequency
  • J+1: One day after radiofrequency
  • Discharge from hospital
  • 7 days after discharge from hospital
  • 1 month after radiofrequency
  • 2 months after radiofrequency
  • 3 months after radiofrequency

Here, are presented only data collected 1 month after radiofrequency.
Algology assessment 1 month after radiofrequency
Intensity of Pain (Minimum, Average, Maximum)
Tidsramme: Algology assessment 2 months after radiofrequency

According to a discrete 11-points numerical scale which ranges from 0 (low pain) to 11 (intense pain), intensity of pain (Minimum, Average, Maximum) has been evaluated at different time point between pre-selection and up to 3 months after radiofrequency.

Assessment of intensity of pain has been done in this order at:

  • Pre-selection visit: First algology assessment within a week (± 3 days) after the radiology consultation,
  • Inclusion visit: Second algology assessment (One week after the first algology assessment)
  • J-1: one day before radiofrequency
  • J+1: One day after radiofrequency
  • Discharge from hospital
  • 7 days after discharge from hospital
  • 1 month after radiofrequency
  • 2 months after radiofrequency
  • 3 months after radiofrequency

Here, are presented only data collected 2 months after radiofrequency.
Algology assessment 2 months after radiofrequency
Intensity of Pain (Minimum, Average, Maximum)
Tidsramme: Algology assessment 3 months after radiofrequency

According to a discrete 11-points numerical scale which ranges from 0 (low pain) to 11 (intense pain), intensity of pain (Minimum, Average, Maximum) has been evaluated at different time point between pre-selection and up to 3 months after radiofrequency.

Assessment of intensity of pain has been done in this order at:

  • Pre-selection visit: First algology assessment within a week (± 3 days) after the radiology consultation,
  • Inclusion visit: Second algology assessment (One week after the first algology assessment)
  • J-1: one day before radiofrequency
  • J+1: One day after radiofrequency
  • Discharge from hospital
  • 7 days after discharge from hospital
  • 1 month after radiofrequency
  • 2 months after radiofrequency
  • 3 months after radiofrequency

Here, are presented only data collected 3 months after radiofrequency.
Algology assessment 3 months after radiofrequency
Oral Morphine Consumption or Oral Morphine Equivalent (Immediate and Sustained Release Forms) (mg) Per Day
Tidsramme: Preselection: First algology visit (within a week (± 3 days) after the radiology consultation)

Patients were provided with a pain notebook. This notebook allowed the patient to describe the pain specific to the metastasis concerned.

In particular, information about the dose of oral morphine consumption or oral morphine equivalent in mg per day.

This pain notebook has been evaluated between the radiology consultation and three months after radiofrequency.
Preselection: First algology visit (within a week (± 3 days) after the radiology consultation)
Oral Morphine Consumption or Oral Morphine Equivalent (Immediate and Sustained Release Forms) (mg) Per Day
Tidsramme: Inclusion: Second algology visit (One week after the first algology visit)

Patients were provided with a pain notebook. This notebook allowed the patient to describe the pain specific to the metastasis concerned.

In particular, information about the dose of oral morphine consumption or oral morphine equivalent in mg per day.

This pain notebook has been evaluated between the radiology consultation and three months after radiofrequency.
Inclusion: Second algology visit (One week after the first algology visit)
Oral Morphine Consumption or Oral Morphine Equivalent (Immediate and Sustained Release Forms) (mg) Per Day
Tidsramme: J-1 (One day before radiofrequency)

Patients were provided with a pain notebook. This notebook allowed the patient to describe the pain specific to the metastasis concerned.

In particular, information about the dose of oral morphine consumption or oral morphine equivalent in mg per day.

This pain notebook has been evaluated between the radiology consultation and three months after radiofrequency.
J-1 (One day before radiofrequency)
Oral Morphine Consumption or Oral Morphine Equivalent (Immediate and Sustained Release Forms) (mg) Per Day
Tidsramme: Discharge from hospital

Patients were provided with a pain notebook. This notebook allowed the patient to describe the pain specific to the metastasis concerned.

In particular, information about the dose of oral morphine consumption or oral morphine equivalent in mg per day.

This pain notebook has been evaluated between the radiology consultation and three months after radiofrequency.
Discharge from hospital
Oral Morphine Consumption or Oral Morphine Equivalent (Immediate and Sustained Release Forms) (mg) Per Day
Tidsramme: 7 days after discharge

Patients were provided with a pain notebook. This notebook allowed the patient to describe the pain specific to the metastasis concerned.

In particular, information about the dose of oral morphine consumption or oral morphine equivalent in mg per day.

This pain notebook has been evaluated between the radiology consultation and three months after radiofrequency.
7 days after discharge
Oral Morphine Consumption or Oral Morphine Equivalent (Immediate and Sustained Release Forms) (mg) Per Day
Tidsramme: 1 month after radiofrequency

Patients were provided with a pain notebook. This notebook allowed the patient to describe the pain specific to the metastasis concerned.

In particular, information about the dose of oral morphine consumption or oral morphine equivalent in mg per day.

This pain notebook has been evaluated between the radiology consultation and three months after radiofrequency.
1 month after radiofrequency
Oral Morphine Consumption or Oral Morphine Equivalent (Immediate and Sustained Release Forms) (mg) Per Day
Tidsramme: 2 months after radiofrequency

Patients were provided with a pain notebook. This notebook allowed the patient to describe the pain specific to the metastasis concerned.

In particular, information about the dose of oral morphine consumption or oral morphine equivalent in mg per day.

This pain notebook has been evaluated between the radiology consultation and three months after radiofrequency.
2 months after radiofrequency
Oral Morphine Consumption or Oral Morphine Equivalent (Immediate and Sustained Release Forms) (mg) Per Day
Tidsramme: 3 months after radiofrequency

Patients were provided with a pain notebook. This notebook allowed the patient to describe the pain specific to the metastasis concerned.

In particular, information about the dose of oral morphine consumption or oral morphine equivalent in mg per day.

This pain notebook has been evaluated between the radiology consultation and three months after radiofrequency.
3 months after radiofrequency
Total Intravenous Morphine Dose (mg)
Tidsramme: 24 hours after radiofrequency

Total intravenous dose of morphine 24 hours after the radiofrequency was assessed during the patient's hospital stay.

As a reminder, the post-operative analgesic treatment included intravenous paracetamol (4 g / 24h) and patient-controlled analgesia (PCA).
24 hours after radiofrequency
Bolus Dose in mg Administered by Patient-controlled Analgesia (PCA)
Tidsramme: 24 hours after radiofrequency
As a reminder, the post-operative analgesic treatment included intravenous paracetamol (4 g / 24h) and patient-controlled analgesia (PCA).
24 hours after radiofrequency
Standardised Quality of Life Scores (EORTC - QLQ-C30)
Tidsramme: Inclusion

Quality of life Questionnaire -Core 30 (QLQ-C30) developed in 1986 by the European Organization for Research and Treatment of Cancer (EORTC) assesses quality of life across 15 dimensions :

5 functional dimensions : Physical functioning, Role functioning, Emotional, Cognitive functioning, Social functioning; 9 symptomatic dimensions: Fatigue, Nausea and vomiting, Pain, Dyspnea, Insomnia, Appetite loss, Diarrhoea, Financial difficulties;

1 global health dimension: Global health status/QoL

Each dimension is a standardised score ranges from 0 to 100. A low score corresponds to a low functional level, an absence of symptoms or a low level of QoL/ overall health and, conversely, so that a high score corresponds to a high functional level, a high presence of symptoms or a high level of QoL/overall health.
Inclusion
Standardised Quality of Life Scores (EORTC - QLQ-C30)
Tidsramme: 2 months after radiofrequency

Quality of life Questionnaire -Core 30 (QLQ-C30) developed in 1986 by the European Organization for Research and Treatment of Cancer (EORTC) assesses quality of life across 15 dimensions :

5 functional dimensions : Physical functioning, Role functioning, Emotional, Cognitive functioning, Social functioning; 9 symptomatic dimensions: Fatigue, Nausea and vomiting, Pain, Dyspnea, Insomnia, Appetite loss, Diarrhoea, Financial difficulties;

1 global health dimension: Global health status/QoL

Each dimension is a standardised score ranges from 0 to 100. A low score corresponds to a low functional level, an absence of symptoms or a low level of QoL/ overall health and, conversely, so that a high score corresponds to a high functional level, a high presence of symptoms or a high level of QoL/overall health.
2 months after radiofrequency

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Institut Bergonié

Etterforskere

  • Studiestol: Florence Dixmerias, MD, Institut Bergonié

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Hjelpsomme linker

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

24. desember 2007

Primær fullføring (Faktiske)

11. februar 2016

Studiet fullført (Faktiske)

16. mars 2016

Datoer for studieregistrering

Først innsendt

9. juli 2008

Først innsendt som oppfylte QC-kriteriene

9. juli 2008

Først lagt ut (Anslag)

10. juli 2008

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

26. mars 2021

Siste oppdatering sendt inn som oppfylte QC-kriteriene

25. mars 2021

Sist bekreftet

1. mars 2021

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • CDR0000589594
  • IB-MEDOR (Annen identifikator: Institute Bergonie)
  • IB-2007-16 (Annen identifikator: Institute Bergonie)
  • INCA-RECF0498 (Annet stipend/finansieringsnummer: INCA)
  • 2007-002686-13 (EudraCT-nummer)

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Nei

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Kliniske studier på Smerte

Søk i lignende forsøk

Sponsorer og samarbeidspartnere

Medisinsk tilstand

Legemiddelintervensjoner

CROs by country

CROs in Angola

Forhold

Sjeldne sykdommer

Legemiddelintervensjoner

Kosttilskudd

Sponsor / samarbeidspartnere

Steder

3
Abonnere