- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT04634656
Lidocaine on Early Cognitive Dysfunction in Shoulder Arthroscopy
Neuroprotective Effects of Lidocaine on Early Postoperative Cognitive Dysfunction in Patients Undergoing Shoulder Arthroscopy With Beach Chair Position: a Randomized Trial
Studieoversikt
Status
Intervensjon / Behandling
Detaljert beskrivelse
Arthroscopic diagnosis and treatment of shoulder disorders have replaced open procedure as the primary treatment method. The beach chair (BCP) and lateral decubitus (LDP) positions are both considered as reliable techniques for performing effective arthroscopic shoulder surgeries. The usage of BCP for shoulder arthroscopic operations started from early 1980s.
The advantages of BCP include lack of brachial plexus strain, good intra-articular visualization, with the ease of conversion to an open approach if required.
The BCP combined with deliberate hypotension has been used to decrease intraoperative blood loss and allow a relatively blood-free surgical field. However, this combination has the risk to impair cerebral perfusion pressure and oxygenation during surgery and produce cerebral ischemia.
Lidocaine, a commonly used local anesthetic and class IB antiarrhythmic drug, that readily crosses the blood - brain barrier. Evans et al. initially reported cerebral protection of lidocaine in a feline model of cerebral arterial gas embolism. Later on, the effects of lidocaine on perioperative neuroprotection were detected. However, the mechanisms underlying lidocaine treatment-induced neuroprotection remain incompletely understood.
Lidocaine may provide cerebral protection through many mechanisms, including decreasing the cerebral metabolic rate, decelerating the ischemic transmembrane ion shift, and reducing the ischemic excitotoxin release.
Studietype
Registrering (Forventet)
Fase
- Fase 2
Kontakter og plasseringer
Studiesteder
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Asyut
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Assiut, Asyut, Egypt, 71515
- Rekruttering
- Seham Mohamed Moeen
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Ta kontakt med:
- Seham M Moeen, MD
- Telefonnummer: 02 01006386324
- E-post: seham.moeen@yahoo.com
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Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Beskrivelse
Inclusion Criteria:
- Patients undergoing elective arthroscopic shoulder surgery under general anesthesia in beach chair position (BCP),
- Age 20 to 65 years old.
Exclusion Criteria:
- Mini-Mental State Examination (MMSE) score < 23 before surgery
- History of neurological disease (such as previous episodes of cerebral ischemia or stroke).
- History of psychological disorder
- Suspected history of adverse reactions to lidocaine
- Drug or alcohol abuse
- History of diabetes mellitus, sever hypertension, severe anemia, hepatic or renal dysfunction
- Unwillingness to comply with protocol.
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Forebygging
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Firemannsrom
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
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Aktiv komparator: Group L
Patients will receive lidocaine in a loading dose of 1 mg/ kg diluted in 10 ml of normal saline that will be infused over 5 minutes after induction of anesthesia then followed by a continuous infusion at 1.5 mg/ kg/ h diluted in normal saline to a volume of 50 ml until the end of surgery.
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Patients will receive lidocaine in a loading dose of 1 mg/ kg diluted in 10 ml of normal saline that will be infused over 5 minutes after induction of anesthesia then followed by a continuous infusion at 1.5 mg/ kg/ h diluted in normal saline to a volume of 50 ml until the end of surgery
Andre navn:
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Placebo komparator: Group C
Patients will receive normal saline after induction of anesthesia with the same volume and rate changes as lidocaine group until the end of surgery.
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Patients will receive normal saline after induction of anesthesia with the same volume and rate changes as lidocaine group until the end of surgery
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
---|---|---|
Postoperative cognitive function
Tidsramme: 3 days after surgery
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Assessed using Mini-Mental State Examination (MMSE) test
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3 days after surgery
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Samarbeidspartnere og etterforskere
Sponsor
Studierekorddatoer
Studer hoveddatoer
Studiestart (Faktiske)
Primær fullføring (Forventet)
Studiet fullført (Forventet)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
- Psykiske lidelser
- Patologiske prosesser
- Postoperative komplikasjoner
- Nevrokognitive lidelser
- Kognisjonsforstyrrelser
- Kognitiv dysfunksjon
- Postoperative kognitive komplikasjoner
- Fysiologiske effekter av legemidler
- Molekylære mekanismer for farmakologisk virkning
- Anti-arytmimidler
- Sentralnervesystemdepressiva
- Agenter fra det perifere nervesystemet
- Sensoriske systemagenter
- Bedøvelsesmidler
- Membrantransportmodulatorer
- Anestesimidler, lokal
- Spenningskontrollerte natriumkanalblokkere
- Natriumkanalblokkere
- Lidokain
Andre studie-ID-numre
- SM 2020
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
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