Development of Endothelial Biomarkers (NUTREND)

Inclusion Criteria:

• - 40 to 65 years old
• male
• non-smokers

Specific inclusion criteria for healthy subjects :

• Healthy subjects should not take antihypertensive or statin.
• Healthy subjects should not present metabolic syndrome but one criterion of the metabolic syndrome will be tolerated.

Specific inclusion criteria for subjects with metabolic syndrome :

- subjects with metabolic syndrome must have at least 3 of the 5 criteria associated with the metabolic syndrome.

Exclusion Criteria:

• treatment vasodilator nitric oxide liberating,
• diabetes and coronary artery disease,
• chronic alcoholism,
• severe hepatic impairment,
• end stage renal failure or dialysis,
• neurological tremor,
• cancer, mental illness or other severe disease which can impact informed consent and / or results,
• Refusal to be registered in the National File of Volunteers
• Person in exclusion of the National Volunteer File