Development and Validation of a Tumour Oxygenation Monitoring Probe
研究概览
详细说明
Tumour hypoxia is feature common to most solid tumours, with significant implications in tumour aggressiveness, metastatic potential and response to therapy. Tumour oxygenation monitoring is likely, therefore, to provide a valuable adjunct in risk stratification and treatment response monitoring.
Diffuse reflectance spectroscopy (DRS) utilises the differing absorption of oxygenated as compared to deoxygenated haemoglobin to provide an accurate measure of tissue oxygenation.
This project aims to develop and validate a tissue oxygenation probe for cancer monitoring. Using the clinical paradigms of rectal and breast cancer, anonymised MRIs of cancer sufferers will guide simulations of tissue optical properties to develop a DRS probe. The 3D reconstructed sans will then be used to 3D print tissue phantom models on which the DRS probe will be validated against reference bench top analysers.
研究类型
注册 (预期的)
联系人和位置
学习地点
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Greater London
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London、Greater London、英国、W21NY
- 招聘中
- Imperial College London
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接触：
- Simon D Dryden, MBChB, MPH
- 电话号码：447828464949
- 邮箱：simon.dryden@imperial.ac.uk
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- MRIs from Breast or Rectal Cancer patients (10 of each)
- Locally advanced Cancers (Stage 2 or 3)
- Patients who went on to receive neoadjuvant chemoradiotherapy.
- Anonymised scans
Exclusion Criteria:
- MRIs from patients under the age of 18, or older than 99 years old will be excluded.
- MRIs from patients who did not receive neoadjuvant therapy for cancer will be excluded.
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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Breast Cancer
Anonymised MRI scans (pre-therapy) of locally advanced breast cancer sufferers.
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The Oxygenation measurements of the novel diffuse reflectance spectroscopy probe
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Rectal Cancer
Anonymised MRI scans (pre-therapy) of locally advanced rectal cancer sufferers.
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The Oxygenation measurements of the novel diffuse reflectance spectroscopy probe
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Oxygenation correlation
大体时间：During Intervention: The DRS probe (intervention) and reference (control) measurements will take place within one hour
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Correlation of sensor oxygenation measurements as compared to gold-standard oxygenation measurements in phantom tissue models
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During Intervention: The DRS probe (intervention) and reference (control) measurements will take place within one hour
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
关键字
其他研究编号
- 19SM5221
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
IPD 计划说明
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
DRS probe的临床试验
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Hospital for Special Surgery, New YorkConventus Orthopaedics, Inc.完全的
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University of PittsburghNational Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health...完全的
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Imperial College LondonCancer Research UK; National Institute for Health Research, United Kingdom招聘中
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National Institutes of Health Clinical Center (CC)完全的
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Assistance Publique - Hôpitaux de ParisUniversité Paris-Saclay主动，不招人