- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01320176
Study to Evaluate the Dosage and Safety of Two Intramuscular Injections of an Investigational Clade B HIV Vaccine
An Open-label, Phase I, Dose-escalation and Safety Study of Two Intramuscular Injections of a Dose of 2.9 Log or 4 Log CCID50 of the Recombinant HIV I Clade B Measles Vaccine Vector in Healthy Adults.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Phase 1
Contacts and Locations
Study Locations
-
-
-
Gent, Belgium, 9000
- Gent University & Hospital, Center for Vaccinology
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Subjects who the investigator believes can and will comply with the requirements of the protocol (e.g. completion of the diary cards, return for follow-up visits) and are available for all scheduled visits at the investigational site
- Adult male and or female subjects between 18 and 27 years old.
- Proven record of measles vaccination (longer than 5 years)
- Measles antibodies titre < 350 IU/L or > 750 IU/L measured in the previous study "CEVAC sero-MV-001".
- Healthy subjects as established by medical history and clinical examination before entering into the study.
- Confirmed HIV negative based on the absence of antibodies and p24.
- Negative for Hepatitis B surface (HBs) antigen, anti-hepatitis B core (HBc antibodies) antibody and anti-Hepatitis C Virus (HCV) antibody
Exclusion Criteria:
- Participation in another clinical study in the last 6 months in which the subject has been exposed to an investigational product (pharmaceutical product or placebo or device) or concurrent participation in another clinical study during the study period.
- Previous inclusion in an HIV vaccine study.
- Receipt of any other vaccination 1 month before or planning to receive any vaccination 1 month after each study vaccination
- Receipt of tuberculin skin test 1 month before or planning to receive a tuberculin test 1 month after each study vaccination
- Receipt of allergy treatment with antigen injections 1 month before or planning to receive allergy treatment with antigen injections 1 month after each study vaccination
- Receipt of blood products or immunoglobulins within 120 days prior to enrolment.
- Measles vaccination or booster within the last 5 years as confirmed by medical history.
- Subject is pregnant or breastfeeding or intends to become pregnant within 9 months of enrolling into the study.
Subject is of childbearing potential and does not agree to use a medically acceptable form of contraception for the duration of the study (9 months post the first investigational HIV vaccination). Medically acceptable forms of contraception include: Contraceptive Medication, Intrauterine device, Double barrier method (Condom* and Occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/suppository.
* A female condom and a male condom should not be used together as friction between the two can result in either product failing.
- History of any significant immunodeficient condition.
- Chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs within the 6 months prior to the first vaccination
- Individuals who are at high risk of acquired HIV infection as determined by the risk assessment questionnaire.
- Individuals who are living and/or working with severely immunocompromised people, children under 15 months old or pregnant women.
- Family history of immunodeficiency and/or personal history of autoimmune disease (including psoriasis, rheumatoid arthritis, autoimmune thyroid disease).
- History of type I or type II diabetes mellitus including cases controlled with diet alone.
- History or ongoing malignancy.
- Major congenital defects or serious chronic illness at the time of enrolment.
- History of serious adverse reactions to vaccine administration, including anaphylaxis and related symptoms, such as urticaria, respiratory difficulty, angioedema and abdominal pain to vaccines, or history of allergic reaction likely to be exacerbated by any component of the vaccine.
- Acute or chronic, clinically significant, as determined by the investigator, pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by physical examination or laboratory screening tests.
- Individuals whose Body Mass index (BMI) is less than 18.5 or greater than 30 (i.e. underweight or obese).
- History of clinically significant, as determined by the investigator, neurological disorder or seizures.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: PREVENTION
- Allocation: NON_RANDOMIZED
- Interventional Model: PARALLEL
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Group A
Subjects received dose A of the investigational HIV vaccine
|
The vaccine will be administered by intramuscular route into the deltoid muscle preferentially of the non dominant arm at Month 0 and Month 3
|
EXPERIMENTAL: Group B
Subjects received dose B of the investigational HIV vaccine
|
The vaccine will be administered by intramuscular route into the deltoid muscle preferentially of the non dominant arm at Month 0 and Month 3
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Occurrence, intensity and relationship to vaccination of solicited local and general adverse events (AEs) except fever
Time Frame: 14-day follow-up after each vaccination
|
14-day follow-up after each vaccination
|
Occurrence, intensity and relationship to vaccination of fever
Time Frame: 21-day follow-up after each vaccination
|
21-day follow-up after each vaccination
|
Occurrence, intensity and relationship to vaccination of unsolicited adverse events (AEs)
Time Frame: 42-day follow-up after each vaccination
|
42-day follow-up after each vaccination
|
Occurrence and relationship to vaccination of any serious AEs (SAEs)
Time Frame: During the study period (Month 0-11)
|
During the study period (Month 0-11)
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Occurrence, intensity and relationship to vaccination of clinically significant abnormal haematology and biochemistry values (grade 3 or 4)
Time Frame: During the study period (Month 0-11)
|
During the study period (Month 0-11)
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Occurrence of shedding of recombinant virus
Time Frame: During the study period (Month 0-11)
|
During the study period (Month 0-11)
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Recombinant virus infectivity
Time Frame: During the study period (Month 0-11)
|
During the study period (Month 0-11)
|
Cell-mediated immune response (CMI)
Time Frame: At day 0, 7, 14, 28, 91, 98, 112, 266
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At day 0, 7, 14, 28, 91, 98, 112, 266
|
Humoral immune response to HIV antigens
Time Frame: At day 14, 28, 84, 98, 112, 266.
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At day 14, 28, 84, 98, 112, 266.
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Geert - Leroux-Roels, MD, Geert.lerouxRoels@UGent.be
Study record dates
Study Major Dates
Study Start
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ESTIMATE)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- MV1-F4-CT1
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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