- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01549600
Comparison of Psyllium and Microcrystalline Cellulose on Glycemic Measures in Subjects With Impaired Fasting Glucose
October 27, 2014 updated by: Procter and Gamble
A Randomized, Controlled Study To Compare the Effects of 2 Types of Dietary Fiber, Psyllium and Microcrystalline Cellulose, on Glycemic Measures in Subjects With Pre-type 2 Diabetes
The Purpose of this study is to compare the effects of 2 types of dietary fiber, psyllium and microcrystalline cellulose (MCC), on glycemic measures in subjects with impaired fasting glucose.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
This study will be conducted at a single study center. Approximately 40 subjects with pre-type 2 diabetes will be enrolled and randomized in this study.
This 22-week study consists of 3 periods: an 8-week treatment period (Visits 2-4), a 6-week washout period, and an 8-week treatment period (Visits 5-7).
Study Type
Interventional
Enrollment (Actual)
18
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
North Carolina
-
Durham, North Carolina, United States, 27710
- Duke University Medical Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- be male or female,
- at least 18 years of age
- in generally good health for the pre-type 2 diabetes population;
- if female, be postmenopausal or if of child-bearing capacity agree to use an adequate form of contraception
- have not used any psyllium containing products within the past 3 months;
- be willing to refrain from taking any psyllium containing products during the study;
- be willing to maintain a lifestyle habits for the duration of the study;
- have a fasting serum glucose of 110 - 125 mg/dL
Exclusion Criteria:
- if female, are pregnant or nursing (lactating);
- have a history of diabetes (diagnosis) or is currently taking medications for diabetes
- participated in a clinical drug study or used investigational drug during the previous 30 days;
- have symptoms and signs suggestive of significant underlying disease, or acute onset of new symptoms and signs of major organ disease, that could become unstable during the trial requiring urgent medical intervention
- have evidence of or treatment history of malignancy within the previous 5 years;
- currently alcohol dependent;
- used anti-psychotics in the previous 3 months;
- used systemic steroidal agents within the last 30 days;
- had used oral or systemic antibiotics or any over-the-counter (OTC) bactericidal medication (eg, bismuth salts) within the last 30 days;
- has been taking any medication that may affect blood glucose or GI motility (eg, calcium channel blockers, beta blockers, antimuscarinics, salicylates etc.) for less than 30 days or 5 times the half life of the drug (need to be stable on the medication);
- have evidence of immunodeficiency including subjects currently taking systemic corticosteroids or immunosuppressive drugs
- have a major psychiatric disorder, including major depression, psychoses, alcohol or substance abuse within the past 2 years;
- has a known sensitivity or allergy to any components of study products, including psyllium and aspartame (see Section 3.5.3);
- were previously screened (ie, Visit 1 procedures) for participation in this study and failed to meet entry criteria;
- have difficulty swallowing
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: psyllium
5.1 g psyllium husk in at least 8 ounces of water
|
1 level tablespoon (~ 5.1 g psyllium husk in the psyllium product) mixed with at least 8 ounces of water, taken twice daily
|
Active Comparator: Microcrsytalline Cellulose
1.18 g Microcrystalline Cellulose in at least 8 ounces of water, taken twice a day
|
1 level tablespoon (~ 1.18 g MCC in the MCC product) mixed with at least 8 ounces of water, taken twice a day
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
fasting serum glucose
Time Frame: 8 weeks
|
mean change from baseline in fasting serum glucose at 8 weeks
|
8 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Study Director: John McRorie, PhD, Procter and Gamble
- Principal Investigator: Mark Feinglos, MD, Duke University
- Principal Investigator: Richard Surwit, PhD, Duke University
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
February 1, 2012
Primary Completion (Actual)
May 1, 2013
Study Completion (Actual)
May 1, 2013
Study Registration Dates
First Submitted
March 6, 2012
First Submitted That Met QC Criteria
March 8, 2012
First Posted (Estimate)
March 9, 2012
Study Record Updates
Last Update Posted (Estimate)
October 28, 2014
Last Update Submitted That Met QC Criteria
October 27, 2014
Last Verified
April 1, 2014
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2011063
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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