- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01896960
ET50 With Fentanyl for Post Caesarean Section Spinal Hypotension (ET-50-Fent)
The Time Required to Remain Sitting After Spinal Anesthesia With Fentanyl for 50% of Patients to Not Experience Hypotension.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Up down sequential analysis is a method developed by Dixon to determine the point where 50% of people will have a positive response and 50% will have a negative response to an intervention. It is a very powerful technique that has been used to determine the median effective dose (referred to as ED50) of many medications. Using this method, patient number 1 is given a certain amount of the intervention being studied. If patient 1 has the desired response, patient 2 in the series is given less of the intervention, and if patient 1 does not have the desired response, patient 2 is given more of the intervention. This is repeated through a series of patients until the dose where there is a 50% response rate is determined. In this study, the investigators wish to use up down sequential analysis to determine the time period a patient should remain seated after intrathecal injection of hyperbaric medication that result in a 50% rate of hypotension, what we will call the ET50 (Estimated Time for 50% of patients to have hypotension). The investigators would like to explore this relationship with 2 clinically used doses of hyperbaric bupivicaine.
Patients scheduled for cesarean delivery arrive in the birthing centre 1-2 The patients will be given the same anesthetic care routinely used in the birthing centre, except that the investigators will control the time that the patient remains seated after injection of intrathecal hyperbaric bupivacaine. The baseline blood pressure and heart rate will be recorded. After intravenous access is obtained, an infusion of normal saline will be commenced at a rate of 100 cc per hour. The patient will be brought to the operating room, and the standard monitors will be placed. The intravenous fluid will be administered at a rate of 500 ml per hour for one hour. The patient will be placed in a sitting position. The landmarks of the spinal canal will be identified with an ultrasound, then using sterile technique, an epidural catheter will be placed in the L2-L3 spinal interspace, and then a 27 gauge whitacre needle will be used to access the intrathecal space at the L4-L5 spinal interspace. After identification of the intrathecal space, hyperbaric bupivacaine will be injected over 30 seconds. The patient will then be left in the sitting position for the predetermined time. The patient will then be placed supine, with a 15 degree wedge under the right hip. The noninvasive blood pressure will be set to measure the blood pressure every minute. Hypotension will be defined as a drop in blood pressure to more than 20% of the patient's preoperative blood pressure. The medications used for treatment of hypotension will be left to the discretion of the treating anesthesiologist. The height of the anesthetic blockade will be measured bilaterally with ice at 1, 5, 10, 15, and 20 minutes after the patient has been placed supine. If the block has not reached T6 by 20 minutes after the patient has assumed the supine position, or if the patient experiences any pain during the cesarean delivery, 5 ml of 2% lidocaine will be administered through the epidural catheter. If this does not suitably manage the pain, the treating anesthesiologist will be allowed to manage the pain as they see fit.
Determination of the time in the sitting position :
The study patient will be considered a success if the duration of time in the sitting position results in no pre-delivery hypotension. The study patient will be considered a failure if the time spent in the sitting position results in pre-delivery hypotension. A patient will be considered an indeterminate result if the ice test fails to show a block reaching T6 by 15 minutes. A patient following a success will be left in the sitting position for 15 seconds less than the preceding patient, and the patient following a failure will be left in the sitting position for 15 seconds more than the preceding patient. A patient following an indeterminate result will remain in the sitting position for the same time as the preceding patient. The first patient in the series will be left in the sitting position for two minutes and half for the 1.5 ml bupivacaine and 6 minutes and half for the 2 ml bupivacaine after the injection of the intrathecal medication.
Dosage determination and blinding:
To see if ET50 is dependent on the dosage of medication given, we will determine the ET50 for 2 doses of hyperbaric bupivicaine with 15 micrograms of fentanyl. Both of the doses we will study are used routinely in clinical practice. Using a computerized randomization schedule, we will randomly assign patients to receive either 2 ml or 1.5 ml of 0.75% hyperbaric bupivacaine, for a total of 15 mg or 12.5 mg of bupivacaine respectively.
Recorded data:
The investigators will record the demographic data of the patient, including height, weight, age, gravidity, parity, weeks gestation, and reason for the cesarean delivery. The investigators will record the medical history of the patient, and medications that the patient takes. The investigators will record the admission heart rate, blood pressure and saturation. The investigators will record the time that the intrathecal medication is injected, and the time that that the patient remains seated after the spinal anesthesia has been commenced. The investigators will record the level of anesthetic blockade at 1,5,10,15,and 20 minutes after the patient has been placed supine. The investigators will record the blood pressure, and heart rate every minute after the patient has been placed supine until the baby has been delivered. The investigators will record any medications used to treat blood pressure before the baby has been born, and any medications used to treat breakthrough pain. The investigators will record the birth time, the baby gender, weight, apgar, and umbilical cord pH.
Study Type
Enrollment (Anticipated)
Phase
- Phase 2
Contacts and Locations
Study Contact
- Name: Aly Elbahrawy, MD
- Email: aly.elbahrawy@mail.mcgill.ca
Study Locations
-
-
Quebec
-
Montreal, Quebec, Canada
- Recruiting
- Royal Victoria Hospital
-
Contact:
- Albert Moore, MD
- Email: moore_albert@hotmail.com
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patients 18 years or older, presenting for scheduled cesarean delivery to the C7 birthing centre.
Exclusion Criteria:
- Unable to communicate in English or French
- Multiple gestations
- Patients with hypertension
- Patients with contraindications to any drug or techniques used in the study
- BMI > 35
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: 2 ml Bupivacaine
2 ml Bupivacaine with 15 micrograms of fentanyl
|
Testing 2 doses of Bupivacaine (12.5 mg and 15 mg) with 15 micrograms fentanyl
|
Active Comparator: 1.5 ml Bupivacaine
1.5 ml Bupivacaine with 15 micrograms of fentanyl
|
Testing 2 doses of Bupivacaine (12.5 mg and 15 mg) with 15 micrograms fentanyl
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Sitting time to avoid hypotension
Time Frame: one hour
|
Sitting time required to avoid a drop of 20% of patient's baseline blood pressure or symptoms of hypotension in 50% of patients
|
one hour
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Pain occurence
Time Frame: One hour
|
One hour
|
Collaborators and Investigators
Investigators
- Principal Investigator: Albert Moore, MD, McGill
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Cardiovascular Diseases
- Vascular Diseases
- Hypotension
- Physiological Effects of Drugs
- Central Nervous System Depressants
- Peripheral Nervous System Agents
- Analgesics
- Sensory System Agents
- Anesthetics, Intravenous
- Anesthetics, General
- Anesthetics
- Analgesics, Opioid
- Narcotics
- Adjuvants, Anesthesia
- Anesthetics, Local
- Fentanyl
- Bupivacaine
Other Study ID Numbers
- 12-273-SDR
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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