- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02220452
The Effect of Intraoperative Music Listening on Sevoflurane Consumption and Recovery Parameters
February 5, 2023 updated by: Dr Kassiani Theodoraki, Aretaieion University Hospital
- The perioperative period can be a significant source of psychological burden, anxiety and fear for patients
- Both pharmacological and non-pharmacological methods have been proposed in order to alleviate perioperative stress
- Music is one of the non-pharmacological methods which have been used in this context, with favorable effects both preoperatively and postoperatively
- The attenuation of perioperative stress through music listening is probably due to the activation of emotional and cognitive processes that evoke feeling of pleasure and can distract patients' attention from fear and unpleasant thoughts related to the surgical procedure
- Little information is available regarding the effect of intraoperative music listening on anesthetized, unconscious patients
- There is a notion that general anesthesia does not completely abolish auditory perception and that some processing of intraoperative events can occur in unconscious patients, even in the absence of postoperative recall
- The investigators hypothesis is that intraoperative music listening can decrease anesthetic requirements and reduce sevoflurane consumption in female patients subjected to abdominal hysterectomy for benign disease.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Detailed Description
- The perioperative period can be a significant source of psychological burden, anxiety and fear for patients
- Both pharmacological and non-pharmacological methods have been proposed in order to alleviate perioperative stress
- Music is one of the non-pharmacological methods which have been used in this context, with favorable effects both preoperatively and postoperatively
- Listening to music during the preoperative period has proved useful as an adjunct to premedication and can even be used instead of premedication. Additionally, listening to music postoperatively can also be useful, since it has been related to a more favorable recovery profile and possible attenuation of postoperative pain. In this context, music has also been used in Intensive Care Units, with measurable effects on anxiety scales and hemodynamic parameters. There are also studies investigating the use of music during operations under regional anesthesia, which have shown that music listening substantially decreases the need for anxiolytic administration throughout the operation
- The attenuation of perioperative stress through music listening is probably due to the activation of emotional and cognitive processes that evoke feelings of pleasure and can distract patients' attention from fear and unpleasant thoughts related to the surgical procedure
- Although the favorable effects of music listening during regional anesthesia for the attenuation of intraoperative stress in conscious patients are more or less expected and easily interpreted, less is known regarding the effect of intraoperative music listening on anesthetized, unconscious patients
- Generally, there is a notion that general anesthesia does not completely abolish auditory perception and that some processing of intraoperative events can occur in unconscious patients, even in the absence of postoperative recall
- The preservation of some form of auditory processing during general anesthesia is not necessarily undesirable and can be used to the patient's benefit, since it has been shown that subjecting patients to therapeutic suggestions during general anesthesia can improve recovery parameters or decrease hospital stay
- The investigators hypothesis is that intraoperative music listening can decrease anesthetic requirements. Therefore, the investigators will investigate sevoflurane consumption necessary to achieve a depth of anesthesia corresponding to bispectral index values of 45-55. Female patients subjected to abdominal hysterectomy for benign disease will be randomized to one of two groups: in the first group, audiotapes playing relaxing soothing orchestral music will be placed on the patients' ears after induction of general anesthesia while in the other group the same set of audiotapes will be used without however playing any music
- Sevoflurane consumption will be estimated by weighing the sevoflurane vaporizer in a high-precision scale before induction and after completion of the surgical procedure. Patients will also be queried regarding recall of any sounds or intraoperative events, dreaming while anesthetized and they will be asked to rate their satisfaction from anesthesia. Recovery parameters will also be investigated, such as postoperative nausea and vomiting and the intensity of postoperative pain. To ensure homogeneity, standardized analgesia will be administered in the two groups
- Since prolactin is related to the neuroendocrine response to stress, blood will also be sampled at predetermined timepoints during anesthesia, to detect potential differences between the two groups
- The clinical interest of this study lies in the fact that if a non-costly intervention such as music listening during anesthesia can lead to reduced requirements of anesthetic agents or to reduced need for postoperative analgesia, this theoretically can be translated to a reduction in anesthetic cost. In addition, improvement in recovery profile parameters could lead to a quicker discharge from the post-anesthesia care unit with reduction in turnaround times and overall time optimization.
Study Type
Interventional
Enrollment (Anticipated)
60
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Athens, Greece, 115 28
- Recruiting
- Aretaieion University Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 70 years (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Female
Description
Inclusion Criteria:
- adult patients, American Society of Anesthesiologists (ASA) distribution I-III, scheduled for elective hysterectomy for benign disease
Exclusion Criteria:
- hearing impairment
- psychiatric disease (depression, dementia)
- mental disability
- concurrent treatment with medication known to affect anesthetic requirement, such as benzodiazepines, anticonvulsants, opioids, psychotropic drugs or alcohol
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: SUPPORTIVE_CARE
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: TRIPLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: music listening during anesthesia
In patients allocated to the music listening group, audiotapes will be placed on patients' ears, playing soothing and relaxing music throughout anesthesia
|
In patients allocated to the music listening group, audiotapes will be placed on patients' ears, playing soothing and relaxing music throughout anesthesia
|
ACTIVE_COMPARATOR: absence of music listening during anesthesia
In patients allocated to absence of music listening group, audiotapes will be placed on the patients' ears, without however playing any music
|
In patients allocated to absence of music listening group, audiotapes will be placed on the patients' ears, without however playing any music
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
sevoflurane consumption during general anesthesia
Time Frame: change of sevoflurane vaporizer weight from before induction to end of anesthesia, an average period of 2 hours
|
the sevoflurane vaporizer will be weighed before anesthetic induction and at the end of anesthesia and consequently sevoflurane consumption during anesthesia will be determined
|
change of sevoflurane vaporizer weight from before induction to end of anesthesia, an average period of 2 hours
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
recall of postoperative events
Time Frame: participants will be followed for the duration of stay in postanesthesia care unit, an average period of 1 hour
|
a questionnaire will be used to assess the specific outcome measure
|
participants will be followed for the duration of stay in postanesthesia care unit, an average period of 1 hour
|
recall of postoperative sounds
Time Frame: participants will be followed for the duration of stay in postanesthesia care unit, an average period of 1 hour
|
a questionnaire will be used to assess the specific outcome measure
|
participants will be followed for the duration of stay in postanesthesia care unit, an average period of 1 hour
|
occurence of postoperative nausea or vomiting
Time Frame: participants will be followed for the duration of stay in postanesthesia care unit, an average period of 1 hour
|
a questionnaire will be used to assess the specific outcome measure
|
participants will be followed for the duration of stay in postanesthesia care unit, an average period of 1 hour
|
intensity of postoperative pain
Time Frame: participants will be followed for the duration of stay in postanesthesia care unit, an average period of 1 hour
|
a verbal rating scale will be used to assess the specific outcome measure
|
participants will be followed for the duration of stay in postanesthesia care unit, an average period of 1 hour
|
satisfaction from anesthesia
Time Frame: participants will be followed for the duration of stay in postanesthesia care unit, an average period of 1 hour
|
a verbal rating scale will be used to assess the specific outcome measure
|
participants will be followed for the duration of stay in postanesthesia care unit, an average period of 1 hour
|
measurement of prolactin levels
Time Frame: during the time that patients are anesthetized, an approximate period of 2 hours
|
during the time that patients are anesthetized, an approximate period of 2 hours
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
sleep diary
Time Frame: first postoperative night
|
a questionnaire will be used to assess the specific outcome measure and participants will be queried in the first postoperative morning
|
first postoperative night
|
sleep diary
Time Frame: second postoperative night
|
a questionnaire will be used to assess the specific outcome measure and participants will be queried in the second postoperative morning
|
second postoperative night
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Wang SM, Kulkarni L, Dolev J, Kain ZN. Music and preoperative anxiety: a randomized, controlled study. Anesth Analg. 2002 Jun;94(6):1489-94, table of contents. doi: 10.1097/00000539-200206000-00021.
- Zhang XW, Fan Y, Manyande A, Tian YK, Yin P. Effects of music on target-controlled infusion of propofol requirements during combined spinal-epidural anaesthesia. Anaesthesia. 2005 Oct;60(10):990-4. doi: 10.1111/j.1365-2044.2005.04299.x.
- Bringman H, Giesecke K, Thorne A, Bringman S. Relaxing music as pre-medication before surgery: a randomised controlled trial. Acta Anaesthesiol Scand. 2009 Jul;53(6):759-64. doi: 10.1111/j.1399-6576.2009.01969.x. Epub 2009 Apr 14.
- Ganidagli S, Cengiz M, Yanik M, Becerik C, Unal B. The effect of music on preoperative sedation and the bispectral index. Anesth Analg. 2005 Jul;101(1):103-6, table of contents. doi: 10.1213/01.ANE.0000150606.78987.3B.
- Block RI, Ghoneim MM, Sum Ping ST, Ali MA. Human learning during general anaesthesia and surgery. Br J Anaesth. 1991 Feb;66(2):170-8. doi: 10.1093/bja/66.2.170.
- Evans C, Richardson PH. Improved recovery and reduced postoperative stay after therapeutic suggestions during general anaesthesia. Lancet. 1988 Aug 27;2(8609):491-3. doi: 10.1016/s0140-6736(88)90131-6.
- Lindh A, Carlstrom K, Eklund J, Wilking N. Serum steroids and prolactin during and after major surgical trauma. Acta Anaesthesiol Scand. 1992 Feb;36(2):119-24. doi: 10.1111/j.1399-6576.1992.tb03436.x.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
August 1, 2014
Primary Completion (ANTICIPATED)
December 1, 2024
Study Completion (ANTICIPATED)
December 1, 2024
Study Registration Dates
First Submitted
August 17, 2014
First Submitted That Met QC Criteria
August 19, 2014
First Posted (ESTIMATE)
August 20, 2014
Study Record Updates
Last Update Posted (ACTUAL)
February 8, 2023
Last Update Submitted That Met QC Criteria
February 5, 2023
Last Verified
February 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Sofia-Music
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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