- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02302703
Low FODMAP (Fermentable Oligo-,di-,Mono-saccharides and Polyols) Versus Gluten-free Diet in Pediatric IBS Patients; a Cross-over Randomized Trial.
Background: IBS (irritable bowel syndrome) describes chronic abdominal pain, which may be relieved with defecation and a change in stool frequency and consistency. Its prevalence among children and adolescents is estimated to be 10-15%. Non-Celiac Gluten Sensitivity is defined as gastrointestinal symptoms which increase with eating gluten-containing foods and improve with a gluten-free diet. FODMAP (fermentable oligo-,di-,mono-saccharides and polyols) are carbohydrates that are not absorbed well in the small intestines, therefore fermented by gut microbiota, increasing osmotic load at the intestine causing fluid shift and gas production. The patient suffers bloating, abdominal pain, flatulence and change of stool consistency. Many foods are FODMAP-rich, including fruit and vegetables, legumes, artificial sweeteners and soft drinks.
Working hypothesis and aims: To study the effect of Low FODMAP diet vs. Gluten free on gastrointestinal symptoms in children with IBS, assuming a beneficial effect based on research in adults.
Methods: 40 children with IBS, aged 6-18 years, will be examined by the pediatric gastroenterology team at Hadassah. All children will record one week of baseline diet and symptoms, then will be randomly selected into a low-FODMAP or Gluten-free diet for one week, together with a washout period of one week between the diets. During the two weeks of intervention diets, the children aided by their parents will document and score symptoms (bowel movements, abdominal pain, flatulence). An analysis of the symptom score will measure the anticipated influence of each diet against baseline diet and symptoms.
Expected results: In previous studies, a change in symptoms was viewed within a few days. We expect to see a reduction of symptoms in one or other of the diets, to prove our hypothesis.
Study Overview
Status
Intervention / Treatment
Detailed Description
Outline of Study Design, including Plan of the Study and Methods:
Aims: comparing the effects of low FODMAP diet versus gluten-free diet on IBS symptoms in children.
Study design: prospective randomized, crossover trial. Study Population: we are aiming to recruit 40 children aged 6-18 years who answer the pediatric ROME III criteria for IBS. Children will be recruited to the study by physicians at pediatric gastroenterology clinics.
Exclusion criteria:
- Other diagnosis (e.g. inflammatory bowel disease, celiac disease).
- Patient receiving chronic medical therapy.
- Patient already on a restrictive diet (e.g. gluten-free, lactose-free) All patients will document baseline diet - a diary of 7 days by parents/patient specifying exact contents of meals. They will document and score baseline symptoms including stool consistency and frequency, abdominal pain, bloating and flatulence. The baseline documentation will be performed by the child, or by his parents, according to the patient's age and ability.
The patients will be randomly selected to one of the intervention groups. A clinical dietitian has created interventional diets. Half of the patients will start with the low FODMAP diet and half will start with Gluten free. After 7 days, the participants will return to a 7 days washout period of their regular diet. After this period, the groups will switch between the intervention diets, for additional 7 days. During the two weeks of intervention diets, the patients will document and score symptoms as described for the baseline documentation.
-There will be special consideration to several dietary elements in the baseline diet, e.g. patients who may regularly consume high lactose, gluten or FODMAP in their daily diet.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Michael Wilschanski, Prof
- Phone Number: 9722-5845039
- Email: michaelwil@hadassah.org.il
Study Locations
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Jerusalem, Israel
- Recruiting
- Hadassah Medical Organization
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Sub-Investigator:
- Maor Chavkin, MD
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- children who answer the pediatric ROME III criteria for IBS
Exclusion Criteria:
- Other diagnosis (e.g. inflammatory bowel disease, celiac disease).
- Patient receiving chronic medical therapy.
- Patient already on a restrictive diet (e.g. gluten-free, lactose-free)
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Crossover Assignment
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: the low FODMAP diet
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Active Comparator: Gluten free diet
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
abdominal pain score
Time Frame: 7 days
|
7 days
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- fodmap1-HMO-CTIL
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Effects of Low FODMAP Diet Versus Gluten-free Diet on IBS Symptoms in Children
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Clinical Trials on low FODMAP diet vs Gluten free diet
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University of Erlangen-Nürnberg Medical SchoolCompleted
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University of GaziantepCompletedIrritable Bowel SyndromeTurkey
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Fondazione IRCCS Ca' Granda, Ospedale Maggiore...UnknownCeliac DiseaseItaly
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University Hospital, Clermont-FerrandInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement and other collaboratorsRecruitingAnkylosing SpondyloarthritisFrance
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Ashok TutejaUnited States Department of DefenseUnknown
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McGill University Health Centre/Research Institute...Louise and Alan Edwards FoundationActive, not recruitingFibromyalgia | Diet, Gluten-FreeCanada
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Fondazione IRCCS Ca' Granda, Ospedale Maggiore...Recruiting
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University of Southern DenmarkOdense University Hospital; University Hospital Bispebjerg and Frederiksberg; Hospital of Southern Jutland and other collaboratorsNot yet recruitingInflammatory Bowel Diseases | Ulcerative ColitisDenmark
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Massachusetts General HospitalTerminated
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Sahlgrenska University Hospital, SwedenCompletedIrritable Bowel SyndromeSweden