Effectiveness of Gum Chewing on Ileus in Chinese Colorectal Patients Underwent Laparoscopic Colorectal Surgery

Effectiveness of Gum Chewing on Reduction of Postoperative Paralytic Ileus for Chinese Colorectal Cancer Patients Underwent Laparoscopic Colorectal Surgery and Enhanced Recovery Program

Gum chewing group will have less ileus and early resume of bowel motion than control group.

Study Overview

• Status: Completed
• Conditions: Colorectal Cancer
• Intervention / Treatment: Other: bubble gum

Detailed Description

The standardize surgical techniques, less used of epidural analgesia, early ambulation and used of naso-gastric tube for decompression are aimed to reduce the paralytic ileus after abdominal surgery . Most Western studies have examined and found that gum chewing are able to prevent postoperative ileus or promotes early bowel function after abdominal surgery.

• Study Type: Interventional
• Enrollment (Actual): 92
• Phase: Not Applicable

Contacts and Locations

Study Locations

• China
  • Hong Kong, China
    • Queen Mary Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Patients with newly diagnosed colorectal cancer undergoing laparoscopic resection in in Queen Mary Hospital
• At least 18 years
• Speak Cantonese
• Able to follow study protocol and chewing gum study

Exclusion Criteria:

• Cognitive disability
• Requirement of epidural analgesia
• Requirement of intensive care unit/ High dependency unit care postoperatively
• Inability to chew
• Presence of procedure other than colorectal resection
• Non Chinese

Study Plan

How is the study designed?

Design Details

• Primary Purpose: PREVENTION
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: SINGLE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: bubble gum chewing and routine care; Start chewing gum on postoperative day at three times daily with no more than 30 minutes till discharged	Other: bubble gum; Chewing gum group patients performing gum chewing on postoperative day 1 at three times daily for 30 minutes after operation and until discharged.
NO_INTERVENTION: routine care; Non interventional group will receive existing routine care as usual

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to first flatus	Time to passage of flatus after surgery was significantly shorter in the intervention group (22 vs 39 hours, p=0.007).	from postoperative day 0 till an expected average of day 7

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to first sense of hunger	Patients in the intervention group also noticed feeling of hunger earlier (17 vs 40 hours, p<0.001).	from postoperative day 0 till an expected average of day 7
Time to first bowel movement,	The first bowel motion also occurred earlier in the intervention group (22 vs 52 hours, p<0.001)	from postoperative day 0 till an expected average of day 7
Length of stay	There is no difference in length of stay between intervention group or control group	from postoperative day 0 till an expected average of day 7

Collaborators and Investigators

• Sponsor: Shum Nga Fan
• Investigators: Principal Investigator: Nga Fan Shum, Hospital Authority, Queen Mary Hospital

Publications and helpful links

General Publications

• Shum NF, Choi HK, Mak JC, Foo DC, Li WC, Law WL. Randomized clinical trial of chewing gum after laparoscopic colorectal resection. Br J Surg. 2016 Oct;103(11):1447-52. doi: 10.1002/bjs.10277.

Study record dates

Study Major Dates

• Study Start: January 1, 2015
• Primary Completion (ACTUAL): December 1, 2015
• Study Completion (ACTUAL): June 1, 2016

Study Registration Dates

• First Submitted: March 4, 2015
• First Submitted That Met QC Criteria: April 14, 2015
• First Posted (ESTIMATE): April 17, 2015

Study Record Updates

• Last Update Posted (ACTUAL): June 21, 2018
• Last Update Submitted That Met QC Criteria: June 19, 2018
• Last Verified: June 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms; Neoplasms by Site; Gastrointestinal Neoplasms; Digestive System Neoplasms; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Intestinal Neoplasms; Rectal Diseases; Colorectal Neoplasms
• Other Study ID Numbers: CRC03