- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02596126
Secondary Prevention of Cardiovascular Disease in the Elderly Trial (SECURE)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
A total number of 2499 patients have been randomized (1:1) to treatment arms. Patients will be recruited across seven countries in Europe (Spain, Italy, Germany, France, Hungary, Poland, and Czech Republic).
Patients will be ≥65 years old and diagnosed with a type 1 myocardial infarction within 6 months prior to study enrolment.
Once the inclusion and exclusion criteria are confirmed, patients will be included in the study after signing informed consent.
Randomization will take place within 6 months of the index event (AMI type I) in a 1:1 ratio to one of the two arms:
- Cardiovascular Polypill (containing Aspirin, Ramipril, and Atorvastatin)
- Usual care
Patients will be followed up for a minimum of 2 years and a maximum of 5 years.
There will be 3 follow up visits at month 6, 12 and 24 and telephone follow up calls at month 18, 36, 48 and 60
Study Type
Enrollment (Actual)
Phase
- Phase 3
Contacts and Locations
Study Locations
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Benešov, Czechia, 25601
- Nemocnice Rudolfa a Stefanie Benešov
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Jihlava, Czechia, 58633
- Nemocnice Jihlava
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Liberec, Czechia, 46030
- Krajská necmonice Liberec
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Olomouc, Czechia, 77900
- Fakultní nemocnice Olomouc
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Slaný, Czechia, 27401
- Nemocnice Slany
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Třinec, Czechia, 73961
- Nemocnice Podlesi
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Praha
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Praha 2, Praha, Czechia, 12808
- Vseobecna fakultni nemocnice v Praze
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Praha 10
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Praha, Praha 10, Czechia, 10034
- Fakultní nemocnice Královské Vinohrady
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Praha 5
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Praha, Praha 5, Czechia, 15030
- Nemocnice Na Homolce
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Angers, France, 49933
- Centre Hospitalier Universitaire d'Angers
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Besançon, France, 25030
- Centre Hospitalier Régional Universitaire de Besançon
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Bron, France, 69500
- Centre Hospitalier Universitaire de Lyon
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Caen, France, 14000
- Centre Hospitalier Universitaire de Caen
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Chambéry, France, 73000
- Centre Hospitalier Métropole Savoie
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Créteil, France, 94000
- Centre Hospitalier Universitaire Henri Mondor
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Dijon, France, 21000
- Centre Hospitalier Universitaire de Dijon
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Grenoble, France, 38000
- Centre Hospitalier Universitaire de Grenoble
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Lille, France, 59037
- Centre Hospitalier Regional et Universitaire de Lille
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Lyon, France, 69365
- Centre Hospitalier St Joseph St Luc
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Nice, France, 06002
- Centre Hospitalier Universitaire de Nice
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Paris, France, 75010
- Hôpital Bichat
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Pessac, France, 33604
- Centre Hospitalier Universitaire de Bordeaux
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Toulouse, France, 31403
- Centre Hospitalier Universitaire de Toulouse
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Angermünde, Germany, 16278
- GLG Fachklinik Wolletzsee GmbH
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Berlin, Germany, 14050
- DRK Klinik Berlin Westend
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Berlin, Germany, 12157
- AVK Vivantes Rehabilitation GmbH
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Berlin, Germany, 12559
- DRK- Kliniken Berlin/ Köpenick
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Berlin, Germany, 13187
- Maria Heimsuchung Caritas-Klinik Pankow
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Berlin, Germany, 13347
- Judisches Krankenhaus
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Berlin, Germany, 13353
- Charité - Universitätsmedizin Berlin, Centrum für Schlaganfallforschung (CSB)
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Berlin, Germany, 13509
- Vivantes Humboldt Klinikum
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Berlin, Germany, 13585
- Vivantes Klinikum Spandu
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Berlin, Germany, 14089
- GK Havelhöhe
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Bitterfeld-Wolfen, Germany, 06749
- Gesundheitszentrum Bitterfeld /Wolfen GmbH
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Burg, Germany, 03096
- Mediclin Reha-Zentrum Spreewald Fachklinik für innere Medizin
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Coswig, Germany, 06869
- MediClin Herzzentrum Coswig
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Berlin
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Berlin - Tegel, Berlin, Germany, 13507
- Medical Park Berlin Humboldtmühle
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Bernau, Berlin, Germany, 16321
- Immanuel Klinikum Bernau Herzzentrum Brandenburg
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Waldsiedlung, Berlin, Germany, 16321
- Brandenburgklinik Berlin-Brandenburg GmbH, Haus Brandenburg/ Kardiologie
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Brandenburg
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Rüdersdorf, Brandenburg, Germany, 15562
- Klinik am See, Rehabilitationszentrum für innere Medizin
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Budapest, Hungary, 1122
- Semmelweis Egyetem Városmajori Szív- és Érgyógyászati Klinika
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Budapest, Hungary, 1125
- Fővárosi Szent János Kórház
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Budapest, Hungary, H-1085
- Szent Rókus Kórház és Intézményei
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Gyula, Hungary, 5700
- Bekes Megyei Pandy Kalman Korhaz
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Kecskemét, Hungary, 6000
- Bacs- Kiskun Megyei Korhaz
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Székesfehérvár, Hungary, 8000
- Fejér Megyei Szent György Egyetemi Kórház
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Veszprém, Hungary, H-8200
- Sydó és Tsa Kft.
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BA
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Cassano Delle Murge, BA, Italy, 70020
- IRCCS Fondazione S. Maugeri Istit. di Cassano Murge
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BG
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Osio Sotto, BG, Italy, 24040
- IOB-Policlinico San Marco
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Seriate, BG, Italy, 24068
- Ospedale Bolognini di Seriate - ASST BERGAMO EST
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Treviglio, BG, Italy, 24047
- ASST di Bergamo Ovest-Ospedale di Treviglio
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BS
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Brescia, BS, Italy, 25123
- ASST degli Spedali Civili di Brescia
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CN
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Alba, CN, Italy, 12051
- Ospedale S.Lazzaro
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CO
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Como, CO, Italy, 22100
- Ospedale Generale di Zona-Ospedale Valduce
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FG
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San Severo, FG, Italy, 71016
- ASL FG Ospedale "Teresa Masselli Mascia"
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GR
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Grosseto, GR, Italy, 58100
- Ospedale Misericordia ASL 9 Grosseto
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LE
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Gallipoli, LE, Italy, 73014
- Ospedale Sacro Cuore Di Gesu
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MB
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Desio, MB, Italy, 20832
- ASST Di Monza-Presidio Ospedaliero di Desio
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Monza, MB, Italy, 20900
- ASST di Monza-Ospedale San Gerardo
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MI
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Milano, MI, Italy, 20122
- IRCCS Ospedale Policlinico di Milano
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Milano, MI, Italy, 20138
- Centro Cardiologico Monzino SpA
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Milano, MI, Italy, 20142
- ASST Santi Paolo e Carlo-Ospedale San Paolo-Polo Univ.
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Milano, MI, Italy, 20149
- IRCCS-Fondazione Don Carlo Gnocchi
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Rozzano, MI, Italy, 20089
- IRCCS Istituto Clinico Humanitas
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San Donato Milanese, MI, Italy, 20097
- IRCCS Policlinico San Donato
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MO
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Sassuolo, MO, Italy, 41049
- Ospedale di Sassuolo S.P.A.
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Passirana-rho
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Passirana, Passirana-rho, Italy, 20017
- ASST Rhodense Ospedale di Passirana
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RM
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Roma, RM, Italy, 00135
- Presidio Ospedaliero San Filippo Neri-ASL Roma E
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RO
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Roma, RO, Italy, 00149
- A.O. San Camillo Forlanini
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SA
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Salerno, SA, Italy, 84131
- Ospedale Ss Giovanni di Dio e Ruggi d'Aragona
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TN
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Trento, TN, Italy, 38122
- Casa di Cura Villa Bianca
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UD
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San Daniele Del Friuli, UD, Italy, 33038
- AAS3 "Alto Friuli, Collinare, Medio Friuli" Ospedale di San Daniele del Friuli-Tolmezzo sede di S. D. del Friuli
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VA
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Saronno, VA, Italy, 21047
- ASST Della Valle Olona-Ospedale di Saronno
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Gdańsk, Poland, 80-952
- Uniwersyteckie Centrum Kliniczn
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Inowrocław, Poland, 88-100
- Szpital Wielospecjalistyczny im. Dr. Ludwika Błażka w Inowrocławiu
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Kraków, Poland, 31-202
- Krakowski Szpital Specjalistyczny im. Jana Pawła II
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Kłodzko, Poland, 57-300
- Zespół Opieki Zdrowotnej w Kłodzku
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Legnica, Poland, 59-220
- Wojewodzki Szpital Specjalistyczny w Legnicy
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Wałbrzych, Poland, 58-309
- Specjalistyczny Szpital im. Dra Alfreda Sokołowskiego
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Wrocław, Poland, 50-315
- Centrum Kardiologiczne "Pro Corde" Sp. z o.o.
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Wrocław, Poland, 50-981
- Wojskowy Szpital Kliniczny z Poliklinika SP ZOZ
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Świdnica, Poland, 58-100
- Samodzielny Publiczny Zespół Opieki Zdrowotnej w Świdnicy
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Ochojec
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Katowice, Ochojec, Poland, 40-635
- Samodzielny Publiczny Szpital Kliniczny nr 7, Śląskiego Uniwersytetu Medycznego w Katowicach, Górnośląskie Centrum Medyczne im. prof. Leszka Gieca
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A Coruña, Spain, 15006
- Hospital Universitario A Coruña
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Alicante, Spain, 03010
- Hospital General Universitario de Alicante
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Barcelona, Spain, 08036
- Hospital Clinic de Barcelona
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Barcelona, Spain, 08035
- Hospital Universitari Vall d'Hebron
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Córdoba, Spain, 14004
- Hospital Universitario Reina Sofia de Cordoba
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Madrid, Spain, 28006
- Hospital Universitario La Princesa
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Madrid, Spain, 28040
- Hospital Universitario Fundacion Jimenez Diaz
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Madrid, Spain, 28041
- Hospital Universitario 12 De Octubre
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Madrid, Spain, 28040
- Hospital Universitario Clinico San Carlos
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Madrid, Spain, 28003
- Hospital La Luz Quiron
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Madrid, Spain, 28006
- C.H.U. Ruber Juan Bravo
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Madrid, Spain, 28009
- Hospital General Universitario Gregorio Maranon
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Málaga, Spain, 29010
- Hospital Virgen de la Victoria
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Salamanca, Spain, 37007
- Complejo Asistencial Universitario de Salamanca
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Sevilla, Spain, 41009
- Hospital Universitario Virgen Macarena
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Sevilla, Spain, 41013
- Hospital Universitario Virgen del Rocío
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Valencia, Spain, 46026
- Hospital Universitario y Politécnico de La Fe
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Valencia, Spain, 46010
- Hospital Clínic Universitari de Valencia
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Asturias
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Gijón, Asturias, Spain, 33203
- Hospital Universitario de Cabueñes
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Barcelona
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L'Hospitalet De Llobregat, Barcelona, Spain, 08997
- Hospital Univeristari de Bellvitge
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Galicia
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Santiago De Compostela, Galicia, Spain, 15706
- H.C.U.de Santiago De Compostela
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Leon
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León, Leon, Spain, 24008
- Complejo Asistencial Universitario de León
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Madrid
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Alcalá De Henares, Madrid, Spain, 28805
- Hospital Universitario Príncipe de Asturias
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Collado-Villalba, Madrid, Spain, 28400
- Hospital General de Villalba
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Fuenlabrada, Madrid, Spain, 28492
- Hospital De Fuenlabrada
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Majadahonda, Madrid, Spain, 28222
- Hospital Universitario Puerta de Hierro
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Móstoles, Madrid, Spain, 28933
- Hospital Universitario Rey Juan carlos
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Pozuelo De Alarcón, Madrid, Spain, 28223
- Hospital Universitario Quirónsalud Madrid
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Valdemoro, Madrid, Spain, 28340
- Hospital Universitario Infanta Elena
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Murcia
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El Palmar, Murcia, Spain, 30120
- H.C.U. Virgen De La Arrixaca De Murcia
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patients diagnosed with a type 1 myocardial infarction within the previous 6 months.
Subjects must be ≥65 years old, presenting with at least one of the following additional conditions:
- Documented diabetes mellitus or previous treatment with oral hypoglycemic drugs or insulin.
- Mild to moderate renal dysfunction: creatinine clearance 60-30 mL/min/1.73 m2.
- Prior myocardial infarction: defined as an AMI occurring before the index event documented in a medical report.
- Prior coronary revascularization: coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI).
- Prior stroke: history of a documented stroke, defined as an acute episode of focal cerebral, spinal, or retinal dysfunction caused by infarction of central nervous system tissue, not resulting in death.
- Age ≥ 75 years.
- Signing informed consent.
Exclusion Criteria:
- Unable to sign informed consent.
- Contraindications to any of the components of the polypill.
- Living in a nursing home.
- Mental illness limiting the capacity of self-care.
- Participating in another clinical trial.
- Severe congestive heart failure (NYHA III-IV).
- Severe renal disease (Creatinine Clearance (CrCl) <30ml/min/1.73 m2).
- Need for oral anticoagulation at the time of randomization or planned in the future months.
- Any condition limiting life expectancy <2 years, including but not limited to active malignancy.
- Significant arrhythmias (including unresolved ventricular arrhythmias or atrial fibrillation).
- Scheduled coronary revascularization (patients can be randomized after final revascularization is completed within the prespecified timeframe).
- Do not agree to the filing, forwarding and use of his/ her pseudonymised data.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Active Comparator: Treatment Prevention for Secondary CV
Patients allocated to the usual care arm will receive standard of care therapies for secondary prevention according to the ESC guidelines.
Drugs and doses will be left at the discretion of the treating physicians..
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ESC Guideline (2013 guideline on management of stable coronary disease) recommended pharmacological treatment for event prevention.
Other Names:
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Experimental: Cardiovascular Polypill
Patients allocated to the experimental arm will receive a cardiovascular polypill containing aspirin 100 mg, atorvastatin (40 or 20 mg) and ramipril (2.5, 5 or 10 mg) taken orally once a day.
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Cardiovascular Polypill contains Aspirin, Atorvastatin and Ramipril. Participants will receive one of the following cardiovascular polypill: (A) Aspirin 100 mg, Atorvastatin 40mg, and Ramipril (2.5 mg, or 5 mg, or 10mg). or (B) Aspirin 100 mg, Atorvastatin 20mg, and Ramipril (2.5 mg, or 5 mg, or 10mg).
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Difference in the occurrence of Major Adverse Cardiovascular Events (MACE) between the Cardiovascular Combination Polypill AAR and the Standard of Care Treatment
Time Frame: 24 months
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Cardiovascular death, non-fatal myocardial infarction, non-fatal ischemic stroke, and urgent revascularization
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24 months
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Incidence of the first occurrence of any component of the following composite endpoint: CV death, MI, stroke.
Time Frame: Baseline
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Cardiovascular death, non-fatal myocardial infarction, non-fatal ischemic stroke, and urgent revascularization
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Baseline
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Incidence of the first occurrence of any component of the following composite endpoint: CV death, MI, stroke.
Time Frame: 6 months after treatment initiation
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Cardiovascular death, non-fatal myocardial infarction, non-fatal ischemic stroke, and urgent revascularization
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6 months after treatment initiation
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Incidence of the first occurrence of any component of the following composite endpoint: CV death, MI, stroke.
Time Frame: 12 months after treatment initiation
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Cardiovascular death, non-fatal myocardial infarction, non-fatal ischemic stroke, and urgent revascularization
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12 months after treatment initiation
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Evaluate the first occurrence of the individual components of the primary endpoint
Time Frame: 18 months after treatment initiation
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18 months after treatment initiation
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Evaluate the first occurrence of the individual components of the primary endpoint
Time Frame: 24 months after treatment initiation
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24 months after treatment initiation
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Evaluate the first occurrence of the individual components of the primary endpoint
Time Frame: 36 months after treatment initiation
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36 months after treatment initiation
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Evaluate the first occurrence of the individual components of the primary endpoint
Time Frame: 48 months after treatment initiation
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48 months after treatment initiation
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Change in Treatment Adherence
Time Frame: 6 months after patient treatment
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The Morisky-Medication Adherence Scale (8 item) Questionnaire will be administered
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6 months after patient treatment
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Change in Treatment Adherence
Time Frame: 24 months after patient treatment
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The Morisky-Medication Adherence Scale (8 item) Questionnaire will be administered
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24 months after patient treatment
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Change in Patient Satisfaction
Time Frame: 6 months after patient treatment
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The treatment Satisfaction Questionnaire for Medication (TSQM) will be administered
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6 months after patient treatment
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Change in Patient Satisfaction
Time Frame: 24 months after patient treatment
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The treatment Satisfaction Questionnaire for Medication (TSQM) will be administered
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24 months after patient treatment
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Change in Systolic and Diastolic Blood Pressure (SBP and DBP)
Time Frame: Baseline
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Systolic and diastolic blood pressure will be collected and summarized at each timepoint.
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Baseline
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Change in Systolic and Diastolic Blood Pressure (SBP and DBP)
Time Frame: 6 months after patient treatment
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Systolic and diastolic blood pressure will be collected and summarized at each timepoint.
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6 months after patient treatment
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Change in Systolic and Diastolic Blood Pressure (SBP and DBP)
Time Frame: 12 months after patient treatment
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Systolic and diastolic blood pressure will be collected and summarized at each timepoint.
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12 months after patient treatment
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Change in Systolic and Diastolic Blood Pressure (SBP and DBP)
Time Frame: 24 months after patient treatment
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Systolic and diastolic blood pressure will be collected and summarized at each timepoint.
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24 months after patient treatment
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Change in LDL cholesterol level
Time Frame: Baseline
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Non-fasting blood analysis will be collected and LDL cholesterol level evaluated at each timepoint.
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Baseline
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Change in LDL cholesterol level
Time Frame: 12 months after patient treatment
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Non-fasting blood analysis will be collected and LDL cholesterol level evaluated at each timepoint.
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12 months after patient treatment
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Change in LDL cholesterol level
Time Frame: 24 months after patient treatment
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Non-fasting blood analysis will be collected and LDL cholesterol level evaluated at each timepoint.
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24 months after patient treatment
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Regional differences in performance of the polypill in the previous endpoints
Time Frame: 6 months after patient treatment
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Assessed
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6 months after patient treatment
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Regional differences in performance of the polypill in the previous endpoints
Time Frame: 12 months after patient treatment
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Assessed
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12 months after patient treatment
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Regional differences in performance of the polypill in the previous endpoints
Time Frame: 24 months after patient treatment
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Assessed
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24 months after patient treatment
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Health Economic Evaluation Comparing Intervention and Usual Care Arm
Time Frame: 6 months after patient treatment
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Cost differences and Incremental Cost-Effectiveness Ratio (ICER) will be assessed at each timepoint.
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6 months after patient treatment
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Health Economic Evaluation Comparing Intervention and Usual Care Arm
Time Frame: 12 months after patient treatment
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Cost differences and Incremental Cost-Effectiveness Ratio (ICER) will be assessed at each timepoint.
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12 months after patient treatment
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Health Economic Evaluation Comparing Intervention and Usual Care Arm
Time Frame: 24 months after patient treatment
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Cost differences and Incremental Cost-Effectiveness Ratio (ICER) will be assessed at each timepoint.
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24 months after patient treatment
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Change in Quality of Life
Time Frame: Baseline
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The European Quality of Life- 5 Dimensions (EQ-5D) Questionnaire will be administered at each timepoint to evaluate change in quality of life.
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Baseline
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Change in Quality of Life
Time Frame: 24 months after patient treatment
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The European Quality of Life- 5 Dimensions (EQ-5D) Questionnaire will be administered at each timepoint to evaluate change in quality of life.
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24 months after patient treatment
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Incidence of Treatment-Emergent Adverse Events (Safety and Tolerability)
Time Frame: Baseline
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All-cause mortality and adverse events (bleeding, renal dysfunction, drug, allergies, and refractory cough leading to drug discontinuation).
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Baseline
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Incidence of Treatment-Emergent Adverse Events (Safety and Tolerability)
Time Frame: 6 months after patient treatment
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All-cause mortality and adverse events (bleeding, renal dysfunction, drug, allergies, and refractory cough leading to drug discontinuation).
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6 months after patient treatment
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Incidence of Treatment-Emergent Adverse Events (Safety and Tolerability)
Time Frame: 12 months after patient treatment
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All-cause mortality and adverse events (bleeding, renal dysfunction, drug, allergies, and refractory cough leading to drug discontinuation).
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12 months after patient treatment
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Incidence of Treatment-Emergent Adverse Events (Safety and Tolerability)
Time Frame: 18 months after patient treatment
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All-cause mortality and adverse events (bleeding, renal dysfunction, drug, allergies, and refractory cough leading to drug discontinuation).
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18 months after patient treatment
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Incidence of Treatment-Emergent Adverse Events (Safety and Tolerability)
Time Frame: 24 months after patient treatment
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All-cause mortality and adverse events (bleeding, renal dysfunction, drug, allergies, and refractory cough leading to drug discontinuation).
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24 months after patient treatment
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Incidence of Treatment-Emergent Adverse Events (Safety and Tolerability)
Time Frame: 36 months after patient treatment
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All-cause mortality and adverse events (bleeding, renal dysfunction, drug, allergies, and refractory cough leading to drug discontinuation).
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36 months after patient treatment
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Incidence of Treatment-Emergent Adverse Events (Safety and Tolerability)
Time Frame: 48 months after patient treatment
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All-cause mortality and adverse events (bleeding, renal dysfunction, drug, allergies, and refractory cough leading to drug discontinuation).
|
48 months after patient treatment
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Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Valentin Fuster, MD, PhD, Centro Nacional de Investigaciones Cardiovasculares Carlos III
- Study Director: Jose Maria Castellano Vazquez, MD, PhD, Centro Nacional de Investigaciones Cardiovasculares Carlos III
Publications and helpful links
General Publications
- Castellano JM, Pocock SJ, Bhatt DL, Quesada AJ, Owen R, Fernandez-Ortiz A, Sanchez PL, Marin Ortuno F, Vazquez Rodriguez JM, Domingo-Fernandez A, Lozano I, Roncaglioni MC, Baviera M, Foresta A, Ojeda-Fernandez L, Colivicchi F, Di Fusco SA, Doehner W, Meyer A, Schiele F, Ecarnot F, Linhart A, Lubanda JC, Barczi G, Merkely B, Ponikowski P, Kasprzak M, Fernandez Alvira JM, Andres V, Bueno H, Collier T, Van de Werf F, Perel P, Rodriguez-Manero M, Alonso Garcia A, Proietti M, Schoos MM, Simon T, Fernandez Ferro J, Lopez N, Beghi E, Bejot Y, Vivas D, Cordero A, Ibanez B, Fuster V; SECURE Investigators. Polypill Strategy in Secondary Cardiovascular Prevention. N Engl J Med. 2022 Sep 15;387(11):967-977. doi: 10.1056/NEJMoa2208275. Epub 2022 Aug 26.
- Buttgereit T, Palmowski A, Forsat N, Boers M, Witham MD, Rodondi N, Moutzouri E, Navidad AJQ, Van't Hof AWJ, van der Worp B, Coll-Planas L, Voshaar M, de Wit M, da Silva J, Stegemann S, Bijlsma JW, Koeller M, Mooijaart S, Kearney PM, Buttgereit F. Barriers and potential solutions in the recruitment and retention of older patients in clinical trials-lessons learned from six large multicentre randomized controlled trials. Age Ageing. 2021 Nov 10;50(6):1988-1996. doi: 10.1093/ageing/afab147.
Helpful Links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
- Elderly
- Adherence
- Cardiovascular Disease
- Myocardial Infarction
- Randomized Trial
- Polypill
- Prevention of Secondary Cardiovascular Disease
- Cardiovascular Combination Polypill AAR
- Cardiovascular Disease in the Elderly
- SECURE
- Secondary Cardiovascular Disease
- Secondary Cardiovascular Prevention
- Randomized Cardiovascular Trial
- Cardiovascular Polypill
Additional Relevant MeSH Terms
Other Study ID Numbers
- 633765
- 2015-002868-17 (EudraCT Number)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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Bispebjerg HospitalOdense University Hospital; Zealand University Hospital; Hvidovre University... and other collaboratorsRecruitingST Elevation Myocardial Infarction | Acute Myocardial Infarction | Non-ST Elevation Myocardial Infarction (nSTEMI)Denmark
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Barts & The London NHS TrustUniversity College, London; Queen Mary University of LondonCompletedAcute Myocardial InfarctionSwitzerland, Denmark, United Kingdom
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University of LeedsUniversity College, LondonCompletedST-elevation Myocardial Infarction | Non ST-elevation Myocardial Infarction
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Karolinska InstitutetUppsala University; The Swedish Research CouncilActive, not recruitingST Elevation Myocardial Infarction | Acute Myocardial Infarction | Non-ST Elevation Myocardial InfarctionSweden
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Oslo University HospitalVestre Viken Hospital Trust; University of Oslo; University Hospital of North... and other collaboratorsActive, not recruitingST Elevation Myocardial Infarction | Acute Myocardial Infarction | Non-ST Elevation Myocardial InfarctionNorway
Clinical Trials on Treatment Prevention for Secondary CV
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Azienda Ospedaliero-Universitaria di ParmaActive, not recruitingAcute Coronary SyndromeItaly
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University Hospital Inselspital, BerneSchweizerische HerzstiftungCompletedStroke | Cerebrovascular Disorders | PreventionSwitzerland
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Fundació Institut de Recerca de l'Hospital de la...UnknownPharmaceutical Care | Drug Related ProblemsSpain
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Cereneo AGTerminatedStroke, IschemicSwitzerland
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Fundacio d'Investigacio en Atencio Primaria Jordi...Department of Health, Generalitat de CatalunyaUnknownOsteoporotic FracturesSpain
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Abant Izzet Baysal UniversityCompletedQuality of Life | Anxiety | Education | Myocardial Infarction, AcuteTurkey
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Case Western Reserve UniversityCompletedHypertension | Bipolar DisorderUnited States
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Mayo ClinicEnrolling by invitationCardiovascular Risk | Cardiovascular PreventionUnited States
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Institut Investigacio Sanitaria Pere VirgiliWithdrawnStroke | Risk Factor, CardiovascularSpain
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Pennington Biomedical Research CenterEunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaboratorsCompleted