- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02902341
The CoCoS Interventional Trial: Caloric Control in Cardiac Surgery Patients
Background: Malnutrition is widespread among cardiac surgery patients and is independently related to an adverse postoperative evolution or outcome. The investigators aimed to assess whether nutrition therapy (NT) could alter caloric deficit, morbidity, and mortality in patients scheduled for non-emergency coronary artery bypass graft (CABG) or aortic valve surgery.
Methods: 351 patients undergoing either elective CABG or aortic valve surgery were studied. Patients receiving NT were enrolled from January 2013 until December 2014. A historical control group consisted of 142 matched patients. Preoperative nutritional status was evaluated. Resting energy expenditure was measured using indirect calorimetry or calculated. Caloric intake and caloric deficits were assessed. The primary endpoint was to evaluate whether NT could limit caloric deficit (Intake to Need Deviation). A secondary endpoint addressed the potential effect of NT on morbidity and mortality. Patients were followed for one year after surgery.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Background: Malnutrition, often presenting as sarcopenic obesity, is widespread among cardiac surgery patients and is independently related to an adverse postoperative evolution or outcome. Nutritional status and energetic needs or deficits in cardiac surgery patients are poorly documented and undernutrition, though readily modifiable, is an often overlooked condition during hospitalization. The investigators aimed to assess whether nutrition therapy (NT) could alter caloric deficit, morbidity, and mortality in patients scheduled for non-emergency coronary artery bypass graft (CABG) or aortic valve surgery.
Methods: 351 patients undergoing either elective CABG or aortic valve surgery were studied. Patients receiving NT were enrolled from January 2013 until December 2014. A historical control group consisted of 142 matched patients who underwent either type of surgery. In all patients, the NRS 2002 and MUST score were used for evaluating the preoperative nutritional status. Resting energy expenditure was measured using indirect calorimetry or calculated. A dietician assessed daily caloric intake during the entire hospitalization. Caloric deficits were calculated. According to a predefined flow-chart protocol, nutritional interventions were launched on different time points. Interventions varied from nutritional modifications to oral supplementation, tube feeding, and parenteral nutrition. The primary endpoint was to evaluate whether NT could limit caloric deficit (Intake to Need Deviation). A secondary endpoint addressed the potential effect of NT on morbidity and mortality. Patients were followed for one year after surgery.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- adult patients scheduled for conventional non-urgent cardiac surgery type coronary artery bypass graft (CABG) or aortic valve surgery
Exclusion Criteria:
- urgent surgery
- aortic arch surgery or other cardiac surgery procedures requiring sternotomy
- off-pump cardiac surgery
- preoperative hemodynamic instability
- pregnancy
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Control
Standard protocol nutrition.
|
Standard protocol nutrition based on calculated caloric needs.
|
Experimental: Nutrition Therapy
Resting energy expenditure was measured using indirect calorimetry or calculated.
A dietician assessed daily caloric intake during the entire hospitalization.
Caloric deficits were calculated.
According to a predefined flow-chart protocol, nutritional interventions were launched on different time points.
Interventions varied from nutritional modifications to oral supplementation, tube feeding, and parenteral nutrition.
|
Nutrition based on measured caloric needs.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Number of participants with limitation of caloric deficit (Intake to Need Deviation) during hospital stay after cardiac surgery
Time Frame: 3 months (measured at intervals)
|
3 months (measured at intervals)
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Number of participants with overall survival at 1 year or morbidity (acute heart failure, arrythmia, sepsis or pneumonia) during 1 year
Time Frame: 1 year
|
1 year
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Elisabeth De Waele, MD, PhD, UZ Brussel (Vrije Universiteit Brussel)
Publications and helpful links
General Publications
- De Waele E, Mattens S, Honore PM, Spapen H, De Greve J, Pen JJ. Nutrition therapy in cachectic cancer patients. The Tight Caloric Control (TiCaCo) pilot trial. Appetite. 2015 Aug;91:298-301. doi: 10.1016/j.appet.2015.04.049. Epub 2015 Apr 22.
- De Waele E, Nguyen D, De Bondt K, La Meir M, Diltoer M, Honore PM, Spapen H, Pen JJ. The CoCoS trial: Caloric Control in Cardiac Surgery patients promotes survival, an interventional trial with retrospective control. Clin Nutr. 2018 Jun;37(3):864-869. doi: 10.1016/j.clnu.2017.03.007. Epub 2017 Mar 18.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2012/045
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Metabolism and Nutrition Disorders
-
Mondelēz International, Inc.University of SydneyCompletedMetabolism and Nutrition DisordersAustralia
-
Shandong Provincial HospitalRecruitingMetabolism and Nutrition Disorder | Rhythm Nodal | Metabolism Disorder, LipidChina
-
Pennington Biomedical Research CenterCompletedMetabolism and Nutrition DisorderUnited States
-
Ospedale San DonatoUniversity of MilanCompletedMetabolism and Nutrition Disorder
-
Maastricht UniversityCompletedMetabolic Disturbance | Metabolism and Nutrition DisorderNetherlands
-
Indiana UniversityAmerican Society for Parenteral and Enteral NutritionTerminatedMetabolism and Nutrition DisorderUnited States
-
I.R.C.C.S Ospedale Galeazzi-Sant'AmbrogioRecruitingOrthopedic Disorder | Metabolism and Nutrition DisorderItaly
-
Nanjing Medical UniversityNot yet recruitingNutrition | Metabolism DisorderChina
-
Benjamin GollaschMax Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC)...CompletedHypoxia | Metabolism and Nutrition Disorder | Energy MetabolismGermany
-
University of PalermoCompletedGlucose Metabolism Disorders | Bone Resorption | Hepatic Steatosis | Nutrition, Healthy | Dietary Deficiency | Lipid Metabolism DisorderItaly
Clinical Trials on Control
-
Claudia M. WittCompleted
-
University of California, San FranciscoWithdrawn
-
The George InstituteChanghai Hospital; University of CalgaryNot yet recruiting
-
Universidad Nacional de Educación a DistanciaMinisterio de Economía y Competitividad, SpainUnknownChronic Pain | FibromyalgiaSpain
-
University of California, Los AngelesThe National Council on Aging; City of Los Angeles Department of Aging; Los Angeles...Completed
-
Queen's University, BelfastPublic Health Agency, Health and Social Care Research and Development; Tiny...Completed
-
National Taiwan University HospitalEnrolling by invitationCognitive Function | Atrial Fibrillation, PersistentTaiwan
-
Takeshi MorimotoUniversity of the RyukyusActive, not recruitingCoronary Artery Disease | Hypertension | Type 2 Diabetes | DyslipidemiaJapan
-
Johnson & Johnson Vision Care, Inc.TerminatedRefractive Error CorrectionUnited States
-
Vanderbilt University Medical CenterCompleted