- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03017300
Transdiaphragmatic Pressure and Neural Respiratory Drive Measured During Inspiratory Muscle Training in COPD
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Subjects:The diagnosis and severity of all participants were measured using the pulmonary function test according to Global Initiative for Chronic Obstructive Lung Disease.
Inclusion criteria: (1)Severe and very severe COPD (postbronchodilator FEV1/FVC under 70% and FEV1 under 50% of the predicted value (GOLD C and D group); (2)Inspiratory muscle weakness(Maximal Inspiratory Pressure under 60cmH2O); (3) Bronchial dilation test (BDT) negative.
Exclusion criteria: (1) acute exacerbation in the previous 4 weeks; (2) using the oral corticosteroids within4 weeks; (3) history of other respiratory, cardiovascular, neuromuscular, musculoskeletal diseases that could interfere the study.
Study design This was a single-centre, cross-sectional study.
Intervention: Inspiratory resistive training All participants conducted inspiratory resistive training using inspiratory resistive trainer (PFLEX, Respironics Inc, USA). Pdi and EMGdi were recorded synchronously.Inspiratory resistive load was change from low intensity into moderate and high intensity randomly(inspiratory hole diameters was set to 5.3mm, 2.4mm and 1.8mm,respectively)
Inspiratory threshold load training Inspiratory threshold load training was conducted by all participants using the inspiratory threshold load trainer (Threshold Inspiration Muscle Trainer, Respironics Inc, USA) .Inspiratory threshold pressure was set to low, medium and high intensity randomly(threshold pressure was 30%,60% and 80% of MIP, respectively).
Measurements :transdiaphragmatic pressure and neural respiratory drive
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Severe and very severe COPD (postbronchodilator FEV1/FVC under 70% and FEV1 under 50% of the predicted value (GOLD C and D group);
- Inspiratory muscle weakness(Maximal Inspiratory Pressure under 60cmH2O);
- Bronchial dilation test (BDT) negative
Exclusion Criteria:
- acute exacerbation in the previous 4 weeks;
- using the oral corticosteroids within 4 weeks;
- history of other respiratory, cardiovascular, neuromuscular, musculoskeletal diseases that could interfere the study.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: COPD(threshold IMT training)
COPD patient use Inspiratory muscle trainer (Threshold IMT®)
|
A device used to offer threshold load to inspiratory muscle
Other Names:
|
Experimental: COPD(resisive training)
COPD patient use Inspiratory muscle trainer (PFLEX®)
|
A device used to offer resisive to inspiratory muscle
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
transdiaphragmatic pressure
Time Frame: half an hour
|
half an hour
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
neural respiratory drive
Time Frame: half an hour
|
half an hour
|
Collaborators and Investigators
Investigators
- Study Chair: Rongchang Chen, Master, Guangzhou Institude of Respiratory Disease
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- GuangzhouInRD
- GuangzhouIntRD (Other Identifier: Guangzhou Institute of Respiratory Disease)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Chronic Obstructive Pulmonary Disease
-
Spire, Inc.ResMedCompletedSevere Chronic Obstructive Pulmonary Disease | Moderate Chronic Obstructive Pulmonary DiseaseUnited States
-
Karaganda Medical UniversityCompletedChronic Obstructive Pulmonary Disease | Chronic Obstructive Pulmonary Disease Moderate | Chronic Obstructive Pulmonary Disease SevereKazakhstan
-
Randall DebattistaUniversity of Malta, Faculty of Health SciencesNot yet recruitingChronic Obstructive Pulmonary Disease Moderate | Acute Exacerbation of COPD | Chronic Obstructive Pulmonary Disease Severe
-
Cukurova UniversityCompletedAnesthesia | Chronic Obstructive Pulmonary Disease Moderate | Lungcancer | Chronic Obstructive Pulmonary Disease Severe | Chronic Obstructive Pulmonary Disease MildTurkey
-
National Taipei University of Nursing and Health...TerminatedChronic Pulmonary Disease | Chronic Obstructive Pulmonary Disease Exacerbation | Chronic Obstructive Pulmonary Disease With ExacerbationTaiwan
-
Taipei Medical UniversityUnknownChronic Obstructive Pulmonary Disease Severe | Chronic Obstructive Pulmonary Disease End StageTaiwan
-
Kırıkkale UniversityRecruitingCOPD (Chronic Obstructive Pulmonary Disease)Turkey
-
Hopital FochAir Liquide SARecruitingChronic Obstructive Pulmonary Disease SevereFrance
-
Fundación para la Investigación del Hospital Clínico...Not yet recruitingCOPD, Chronic Obstructive Pulmonary DiseaseSpain
-
Canandaigua VA Medical CenterRecruitingChronic Obstructive Pulmonary Disease ModerateUnited States
Clinical Trials on Threshold IMT®
-
Hospital de Clinicas de Porto AlegreCompleted
-
Guangzhou Institute of Respiratory DiseaseCompletedChronic Obstructive Pulmonary DiseaseChina
-
Biruni UniversityThe Scientific and Technological Research Council of TurkeyRecruiting
-
Sykehuset Innlandet HFBergen University CollegeCompletedPulmonary Disease, Chronic ObstructiveNorway
-
University of ValenciaCompletedMuscle Weakness | Other Diagnoses, Comorbidities, and Complications | Syndrome; InstitutionalizationSpain
-
Brno University HospitalRecruiting
-
Ospedali Riuniti TriesteCompleted
-
Istanbul University - Cerrahpasa (IUC)CompletedHeart Failure | Older PeopleTurkey
-
Universitair Ziekenhuis BrusselHasselt University; Jessa HospitalWithdrawnPhysiotherapy | Coronary Artery Bypass Graft Surgery | Valve Replacement | Post-Op Complications
-
Chang Gung Memorial HospitalCompleted