Evaluation of 2 Intensification Treatment Strategies for Neuroblastoma Patients With a Poor Response to Induction (VERITAS)

An International Multicenter Phase II Randomised Trial Evaluating and Comparing Two Intensification Treatment Strategies for Metastatic Neuroblastoma Patients With a Poor Response to Induction Chemotherapy

The main objective is to evaluate the efficacy of two intensified consolidation strategies in very-high risk neuroblastoma (VHR-NBL) patients in terms of event-free survival from randomisation date. This evaluation will follow a hierarchical testing procedure: each experimental treatment will be first evaluated as a single-arm phase 2 study, and in case of positive conclusion, the relative efficacy of both arms will then be evaluated comparatively.

Study Overview

• Status: Terminated
• Conditions: Very High Risk Neuroblastoma
• Intervention / Treatment: Radiation: mIBG; Drug: Topotecan; Procedure: Autologous stem cell transplant; Drug: Thiotepa

Detailed Description

High-risk metastatic neuroblastoma is not cured by a single treatment. All patients who have become long-term survivors have received sequential treatments with various drugs.

For this reason, this trial does not compare two single treatments, but compares two sequential treatment strategies. In these two strategies, most of the components are evidence-based best practice, although the level of evidence supporting each component varies. There is one experimental component in each strategy. Indeed, none of these two treatment schedules can be considered as standard therapy, and none has been previously compared with any standard therapy in a randomised trial.

Although it might be considered that this trial should have a standard therapy arm as a comparator, analysis of patients treated in the SIOPEN HR NBL trial 1 who have failed to meet the R1 criteria has shown a wide heterogeneity of treatments. Therefore, there is no recognised or accepted standard treatment in this very high-risk patient group, and no guidelines exist for poor responders. Survival in this very high-risk group is currently very poor. Considering all these points, it is considered ethical to compare two experimental schedules without a standard comparator.

This trial compares two such strategies in a randomised way. Patients are eligible for entry into the trial if they fail to have an adequate response to induction and therefore cannot proceed directly within the high-risk study to BuMel PBSCR. Eligible patients will be randomised at that time point, even though further standard treatment will be administered before the randomised element, and there may be circumstances when an individual patient although randomised to a particular strategy, is unable to receive the randomised element of treatment. For example, if it proves impossible to perform an adequate PBSC harvest. All randomised patients will be analysed on an intention to treat basis.

Following randomisation, all patients will continue with standard dose chemotherapy with irinotecan and temozolomide for three courses to allow for PBSC harvest (it is not mandatory to have clear bone marrows before attempting a harvest) and to facilitate scheduling of the randomised element of the study which may necessitate referral to another centre.

The patients will then receive one of two investigational intensification therapies according to random allocation:

• high administered activity 131I-mIBG and topotecan and ASCR.
• high-dose thiotepa and ASCR Then all patients will proceed to second high-dose chemotherapy: BuMel and ASCR.

The intensified consolidation chemotherapy will be followed by external radiotherapy as appropriate, by local surgery of the tumour residues as appropriate.

• Study Type: Interventional
• Enrollment (Actual): 34
• Phase: Phase 2

Contacts and Locations

Study Locations

• Austria
  • Innsbruck, Austria, 356020
    • Medizinische Universität Innsbruck
  • Vienna, Austria, 1090
    • St. Anna Kinderspital GmbH
• France
  • Val De Marne
    • Villejuif, Val De Marne, France, 94805
      • Gustave Roussy
• Italy
  • Florence, Italy, 50139
    • Meyer children's Hospita
  • Milano, Italy, 20133
    • Fondazione IRCCS Istituto nazionaleTumori
  • Roma, Italy
    • Ospedale Pediatrico Bambino Gesù
• Netherlands
  • Utrecht, Netherlands
    • Princess Maxima Center
• Spain
  • Cruces, Spain, 48903
    • Hospital Universitario Cruces
  • Valencia, Spain, 46026
    • Hospital Universitario y policnico La Fe

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

1. Metastatic neuroblastoma (NBL)
2. Patient previously treated within the ongoing High Risk Neuroblastoma SIOPEN study or treated with the current standard treatment for very high risk neuroblastoma off-trial
3. mIBG scintigraphy positive at diagnosis and after induction chemotherapy (pre BuMel evaluation).
4. Metastatic response after induction chemotherapy lower than the ongoing High Risk Neuroblastoma SIOPEN trial criteria to be eligible for High Dose Chemotherapy (metastatic response worse than partial response (< PR) or SIOPEN score > 3)
5. Females of childbearing potential must have a negative serum pregnancy test within 7 days prior to initiation of treatment. Sexually active patients must agree to use acceptable and appropriate contraception while on study drug and for one year after stopping the study drug. Acceptable contraception are defined in CTFG Guidelines "Recommendations related to contraception and pregnancy testing in clinical trials". Female patients who are lactating must agree to stop breast-feeding.
6. Written informed consent from parents/legal representative, patient, and age-appropriate assent before any study-specific screening procedures are conducted according to local regional or national guidelines.
7. Patient affiliated to a social security regimen or beneficiary of the same according to local requirements.

Exclusion Criteria:

1. Parenchymal brain metastasis (even one)
2. Progressive disease at study entry
3. Previous high-dose therapy and Autologous Stem Cell Reinfusion
4. Performance status (Karnofsky, Lansky) <70%
5. Patient having received other therapy for cancer treatment than those allowed as per the ongoing High Risk Neuroblastoma SIOPEN trial or as defined in the future frontlines protocol (for HRNBL1 trial : after induction + 2 TVD)

6. Impaired organ function (liver, kidney, heart, lungs)

   • Shortening fraction <28%, or ejection fraction <55%, or clinical evidence of congestive heart failure or uncontrolled cardiac rhythm disturbance
   • Dyspnea at rest and/or pulse oxymetry <95% in air
   • ALT, Bilirubin > 2 ULN
   • Creatinine clearance and/or GFR < 60 ml/min/1.73m^2 and serum creatinine >/= 1.5 mg/dl
7. Any uncontrolled intercurrent illness or infection that in the investigator's opinion would impair study participation
8. Concomitant use with yellow fever vaccine and with live virus and bacterial vaccines
9. Patient allergic to peanut or soya
10. Chronic inflammatory bowel disease and/or bowel obstruction
11. Pregnant or breastfeeding women
12. Known hypersensitivity to the active substance or to any of the excipients of study drugs
13. Known hypersensitivity to dacarbazine
14. Concomitant use with St John's Wort

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Arm A: High administered activity 131I-mIBG radiolabelled with iodine-131 and Topotecan; The trial will evaluate two randomised arms. Each arm includes; three cycles of Temozolomide-Irinotecan, similar in both arms,; a specific consolidation course detailed hereinafter,; a BuMel sequence, followed by an ASCT, similar in both arms,; external radiotherapy as appropriate, and/or local surgery of the tumour residues as appropriate.	Radiation: mIBG; Day 1 131I-mIBG course 1: about 444MBq/kg with in vivo whole-body dosimetry Day 15 131I-mIBG course 2: the target is to deliver a combined whole-body radiation dose of 4 Gy; Drug: Topotecan; Day 1-5 Topotecan 0.7 mg/m2 daily Day 15-19 Topotecan 0.7 mg/m2 daily; Procedure: Autologous stem cell transplant; ASCT as soon as radiation level allows it in ARM A
Experimental: Arm B: High dose Thiotepa; The trial will evaluate two randomised arms. Each arm includes; three cycles of Temozolomide-Irinotecan, similar in both arms,; a specific consolidation course detailed hereinafter,; a BuMel sequence, followed by an ASCT, similar in both arms,; external radiotherapy as appropriate, and/or local surgery of the tumour residues as appropriate.	Procedure: Autologous stem cell transplant; ASCT as soon as radiation level allows it in ARM A; Drug: Thiotepa; Day 1-3 Thiotepa

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Event Free Survival (EFS)	From the randomisation into the VERITAS trial to 3 years

Collaborators and Investigators

• Sponsor: Gustave Roussy, Cancer Campus, Grand Paris
• Collaborators: National Cancer Institute, France
• Investigators: Principal Investigator: Dominique Valteau-Couanet, MD, PhD, Gustave roussy Paris, France

Study record dates

Study Major Dates

• Study Start (Actual): October 1, 2018
• Primary Completion (Actual): August 28, 2023
• Study Completion (Actual): August 28, 2023

Study Registration Dates

• First Submitted: May 23, 2017
• First Submitted That Met QC Criteria: May 23, 2017
• First Posted (Actual): May 24, 2017

Study Record Updates

• Last Update Posted (Actual): September 25, 2023
• Last Update Submitted That Met QC Criteria: September 21, 2023
• Last Verified: September 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms, Nerve Tissue; Neuroectodermal Tumors, Primitive; Neuroectodermal Tumors, Primitive, Peripheral; Neuroblastoma; Physiological Effects of Drugs; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; Antineoplastic Agents; Immunosuppressive Agents; Immunologic Factors; Antineoplastic Agents, Alkylating; Alkylating Agents; Myeloablative Agonists; Topoisomerase Inhibitors; Topoisomerase I Inhibitors; Topotecan; Thiotepa
• Other Study ID Numbers: 2015-003130-27; 2015/2294 (Other Identifier: CSET number)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL; ICF; CSR

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No