"Beverage Hydration Index" of Commercial Therapeutic Beverages

March 5, 2018 updated by: Kurt Sollanek, Sonoma State University

Beverage Hydration Index of Three Commercial Oral Rehydration Therapy ORT Beverages

The "beverage hydration index" (BHI) assesses the hydration potential of any consumable fluid relative to water. The BHI is a relatively new metric. Our purpose was to assess the BHI of beverages never previously tested, including an amino acid-based oral rehydration solution (AA-ORS), a glucose-containing ORS (G-ORS) and a sports drink (SD) compared to water (control).

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The "Beverage Hydration Index" (BHI) was created to assess the degree to which beverages "hydrate", by measuring fluid retention after ingesting a 1 liter bolus and comparing it to water. Drinks with carbohydrates and electrolytes would traditionally be expected to score higher on the BHI due to glucose-sodium cotransport at the gut and osmolality approaching isotonicity with blood. One recent study reported that an oral rehydration solution (ORS) scored better than water, but a "sports drink" did not. No "optimal" BHI beverage composition has been described, nor has an optimal osmolality. Recently, a hypotonic amino acid-based rehydration beverage was developed to take advantage of amino acid-sodium cotransport, thus obviating the need for carbohydrate. However, the BHI of this beverage has not yet been assessed. The purpose of this investigation was to assess the hydration potential of this novel beverage in comparison to a commercially available carbohydrate-containing sports drink and oral rehydration solution.

Study Type

Interventional

Enrollment (Actual)

46

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • California
      • Rohnert Park, California, United States, 94928
        • Sonoma State Univrsity

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 35 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Healthy male or female
  • Aged 18-35
  • BMI 18-27 kg/m2
  • No known cardiovascular, renal or metabolic disease
  • Moderately active
  • Moderate alcohol use

Exclusion Criteria:

  • Overweight or obese (BMI >27 kg/m2)

    • Competitive athletes during competition season
    • Current or former cardiovascular, renal or metabolic disease
    • Habitual consumption of alcohol (>21 units/week) or regular (>1/week) high (10 units) intake*
    • History of psychiatric illness
    • Actively seeking to gain or lose weight

    • Currently taking prescribed medication

      • Example, a 750 ml bottle of wine at 12% ABV contains 0.750 Liters * 12 = 9 units

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Health Services Research
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Beverage Hydration Index of beverages
Subjects will consume 4 different beverages to obtain the beverage hydration index.
Other: enterade
Subjects will consume enterade, which is an amino acid-based oral rehydration solution.
Other: Pedialyte
Subjects will consume Pedialyte
Other: Gatorade
Subjects will consume Gatorade
Other: Water
Subjects will consume water as the control beverage

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Beverage hydration index
Time Frame: 4 hours
beverage hydration index
4 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sonoma State University

Collaborators

Entrinsic Bioscience Inc.

Investigators

  • Principal Investigator: Kurt J Sollanek, Ph.D., Sonoma State University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 17, 2017

Primary Completion (Actual)

April 14, 2017

Study Completion (Actual)

April 14, 2017

Study Registration Dates

First Submitted

August 23, 2017

First Submitted That Met QC Criteria

August 23, 2017

First Posted (Actual)

August 25, 2017

Study Record Updates

Last Update Posted (Actual)

March 7, 2018

Last Update Submitted That Met QC Criteria

March 5, 2018

Last Verified

March 1, 2018

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • IRB Application #2667

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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