- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03359369
Prognostic Value of Serum Cholesterol and Triglyceride in Septic and Non Septic Patients
Prognostic Value of Serum Cholesterol and Triglyceride in Septic and Non Septic Patients: Randomized Double Blinded Study
The primary outcome of this study is to evaluate the difference between the level of serum cholesterol and triglyceride in septic and non septic patients in the ICU. .
The secondary outcome will be to find correlation between the level of serum cholesterol and triglyceride and both Acute physiology And Chronic Health Evaluation Score (APACHE) II(19) and quick Sequential Organ Failure Assessment (qSOFA) score (20) and their relation to mortality.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Type and Site of The study:
This study will be be done at Beni-Suef university hospital SICU after approval of the local ethics and research committee and anesthesia department of Beni-Suef University.
DATE AND PERIOD OF THE STUDY:
The study will be done between June 2017 and June 2018
Study population:
The study population will include the patients (age range between 20 and 70)of both sex (septic and non septic patients e.g. trauma patients, post surgical patients) who will be admitted to the surgical intensive care in Beni Suef University hospital.
Sample size estimation:
Sample technique:
The patients will be randomly assigned into two groups, septic patients (groups) according to established consensus definitions (21) or non septic patients (NS) as post surgical and trauma patients.
The following data will be recorded for each patient: age, sex,weight, cause of ICU admission, administration of vasoactive drugs, length of ICU stay, 28-day mortality, administration of vasoactive drugs, days on mechanical ventilation, Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, quick Sequential Organ Failure Assessment (qSOFA) scores will be recorded.
The following laboratory data will be measured:
cholesterol, triglyceride on days 0 (ICU admission), 1, 3, and 7, 10 and 14.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
-
Banī Suwayf, Egypt, 11391
- Faculty of Medicine, Beni-suef University
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- The study population will include the patients (age range between 20 and 70) of both sex (septic and non septic patients e.g. trauma patients, post surgical patients) who will be admitted to the surgical intensive care in Beni-Suef University hospital
Exclusion Criteria:
- Age less than 20
- Pregnancy
- ICU readmission
- Dyslipidemia
- Patients with liver disease e.g.hepatitis B,hepatitis C , liver cirrhosis, and hepatocellular carcinoma)
- Concomitant of use immunosuppressive therapy
- Using statin or steroid (≥15mg/day) within the previous 7 days
- Patients who had been treated with corticosteroid therapy for septic shock prior to admission to ICU
- Patients sedated by propofol
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Septic Patients
|
other
|
Non Septic Patients
|
other
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
change in the level of serum cholesterol and triglyceride
Time Frame: on days 0, 1, 3, and 7, 10 and 14 days
|
change in the level of serum cholesterol and triglyceride
|
on days 0, 1, 3, and 7, 10 and 14 days
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- doaa rashwan
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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