- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03533166
Effects of a 0.03% CHX Mouth Rinse in Peri-implant Mucositis
Clinical and Microbiological Effects of a 0.03% Chlorhexidine Mouth Rinse in the Prevention of Peri-implant Diseases: a Randomized Clinical Trial
Aim: To evaluate the efficacy of a 0.03% chlorhexidine (CHX) and 0.05% cetyl pyridinium chloride (CPC) mouth rinse, as an adjunct to professionally and patient-administered mechanical plaque removal, in the treatment of peri-implant mucositis.
Material and Methods: Patients displaying peri-implant mucositis in, at least, one implant were included in this randomized, double-blinded, clinical trial. Subjects received a conventional professional prophylaxis (at baseline and 6-month visits) and were instructed to regular oral hygiene practices and to rinse, twice daily, during one year, with a 0.03% CHX and 0.05% CPC mouth rinse, or a placebo. Clinical, radiographic and microbiological data were recorded at baseline, 6 and 12 months. Disease resolution was defined as the absence of bleeding on probing (BOP). Repeated measures ANOVA, Student-t and chi square tests were used.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
-
Madrid, Spain, 28040
- Faculty of Dentistry, Univesity Complutense, Madrid
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- the presence of, at least, one dental implant with clinical signs of peri-implant mucositis, defined as gently bleeding on probing (BOP) and/or suppuration without progressive radiographic bone loss (after at least 1 year of functional loading)
Exclusion Criteria:
- untreated or recurrent periodontitis [presence of nine or more sites with PD 5 mm and with full mouth bleeding score (FMBS) > 25%];
- implants affected by peri-implantitis, (BOP and/or suppuration and progressive radiographic bone loss);
- removable implant-retained prosthesis;
- history of intake of systemic antibiotics within the previous month or other chronic systemic medications that could interfere with the study outcomes;
- and women being pregnant or breast-feeding.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Chlorhexidine
Mechanical treatment + 0.03% chlorhexidine + 0.05% CPC mouthrinse
|
0.03% Chlorhexidine + 0.05% CPC mouth rinse
|
Placebo Comparator: Placebo
Mechanical treatment + Placebo mouth rinse
|
Placebo mouth rinse
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change on bleeding on probing on implants
Time Frame: Change baseline-12 months
|
Bleeding on probing (BOP) on implants, evaluated dichotomously (presence/absence), considering a positive score when evident bleeding was observed within 15 s after gentle probing (Jepsen et al. 2015) at baseline, 3, 6, 9 and 12 months. Primary outcome would be considered for the change between baseline and 12 months One blinded and calibrated investigator recorded BOP at 6 sites around implants, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA) Calibration was achieved in double measurement calibration sessions, with a gold standard, on six randomly selected patients within one week. The inter-examiner agreement resulting in kappa (k) values of 0.78 for BOP). |
Change baseline-12 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Bleeding on probing (BOP) on implants
Time Frame: Baseline
|
Bleeding on probing (BOP) on implants, evaluated dichotomously (presence/absence), considering a positive score when evident bleeding was observed within 15 s after gentle probing (Jepsen et al. 2015) at baseline, 3, 6, 9 and 12 months. One blinded and calibrated investigator recorded BOP at 6 sites around implants, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA) Calibration was achieved in double measurement calibration sessions, with a gold standard, on six randomly selected patients within one week. The inter-examiner agreement resulting in kappa (k) values of 0.78 for BOP). |
Baseline
|
Bleeding on probing (BOP) on implants
Time Frame: 3 months
|
Bleeding on probing (BOP) on implants, evaluated dichotomously (presence/absence), considering a positive score when evident bleeding was observed within 15 s after gentle probing (Jepsen et al. 2015) at baseline, 3, 6, 9 and 12 months. One blinded and calibrated investigator recorded BOP at 6 sites around implants, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA) Calibration was achieved in double measurement calibration sessions, with a gold standard, on six randomly selected patients within one week. The inter-examiner agreement resulting in kappa (k) values of 0.78 for BOP). |
3 months
|
Bleeding on probing (BOP) on implants
Time Frame: 6 months
|
Bleeding on probing (BOP) on implants, evaluated dichotomously (presence/absence), considering a positive score when evident bleeding was observed within 15 s after gentle probing (Jepsen et al. 2015) at baseline, 3, 6, 9 and 12 months. One blinded and calibrated investigator recorded BOP at 6 sites around implants, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA) Calibration was achieved in double measurement calibration sessions, with a gold standard, on six randomly selected patients within one week. The inter-examiner agreement resulting in kappa (k) values of 0.78 for BOP). |
6 months
|
Bleeding on probing (BOP) on implants
Time Frame: 9 months
|
Bleeding on probing (BOP) on implants, evaluated dichotomously (presence/absence), considering a positive score when evident bleeding was observed within 15 s after gentle probing (Jepsen et al. 2015) at baseline, 3, 6, 9 and 12 months. One blinded and calibrated investigator recorded BOP at 6 sites around implants, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA) Calibration was achieved in double measurement calibration sessions, with a gold standard, on six randomly selected patients within one week. The inter-examiner agreement resulting in kappa (k) values of 0.78 for BOP). |
9 months
|
Bleeding on probing (BOP) on implants
Time Frame: 12 months
|
Bleeding on probing (BOP) on implants, evaluated dichotomously (presence/absence), considering a positive score when evident bleeding was observed within 15 s after gentle probing (Jepsen et al. 2015) at baseline, 3, 6, 9 and 12 months. One blinded and calibrated investigator recorded BOP at 6 sites around implants, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA) Calibration was achieved in double measurement calibration sessions, with a gold standard, on six randomly selected patients within one week. The inter-examiner agreement resulting in kappa (k) values of 0.78 for BOP). |
12 months
|
Bleeding on probing (BOP) on teeth
Time Frame: Baseline
|
Bleeding on probing (BOP) on teeth, evaluated dichotomously (presence/absence), considering a positive score when evident bleeding was observed within 15 s after gentle probing One blinded and calibrated investigator recorded BOP at 6 sites around all teeth, using aPCP15 periodontal probe (HuFriedy® , Chicago, IL, USA). |
Baseline
|
Bleeding on probing (BOP) on teeth
Time Frame: 6 months
|
Bleeding on probing (BOP) on teeth, evaluated dichotomously (presence/absence), considering a positive score when evident bleeding was observed within 15 s after gentle probing One blinded and calibrated investigator recorded BOP at 6 sites around all teeth, using aPCP15 periodontal probe (HuFriedy® , Chicago, IL, USA). |
6 months
|
Bleeding on probing (BOP) on teeth
Time Frame: 12 months
|
Bleeding on probing (BOP) on teeth, evaluated dichotomously (presence/absence), considering a positive score when evident bleeding was observed within 15 s after gentle probing One blinded and calibrated investigator recorded BOP at 6 sites around all teeth, using aPCP15 periodontal probe (HuFriedy® , Chicago, IL, USA). |
12 months
|
Plaque on implants
Time Frame: Baseline
|
Modified plaque index (MPlI) measured at six sites per implant (Mombelli et al. 1987):
One blinded and calibrated investigator recorded MPI at 6 sites around the selected implant, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA). Calibration was achieved in double measurement calibration sessions, with a gold standard , on six randomly selected patients within one week. The inter-examiner agreement resulting in kappa (k) values of 0.79 for MPlI. |
Baseline
|
Plaque on implants
Time Frame: 6 months
|
Modified plaque index (MPlI) measured at six sites per implant (Mombelli et al. 1987):
One blinded and calibrated investigator recorded MPI at 6 sites around the selected implant, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA). Calibration was achieved in double measurement calibration sessions, with a gold standard , on six randomly selected patients within one week. The inter-examiner agreement resulting in kappa (k) values of 0.79 for MPlI. |
6 months
|
Plaque on implants
Time Frame: 12 months
|
Modified plaque index (MPlI) measured at six sites per implant (Mombelli et al. 1987):
One blinded and calibrated investigator recorded MPI at 6 sites around the selected implant, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA). Calibration was achieved in double measurement calibration sessions, with a gold standard , on six randomly selected patients within one week. The inter-examiner agreement resulting in kappa (k) values of 0.79 for MPlI. |
12 months
|
Plaque on teeth
Time Frame: Baseline
|
Modified plaque index (MPlI) measured at six sites per tooth
One blinded and calibrated investigator recorded MPI at 6 sites around teeth using a PCP15 periodontal probe (HuFriedy® , Chicago, IL, USA). |
Baseline
|
Plaque on teeth
Time Frame: 6 months
|
Modified plaque index (MPlI) measured at six sites per tooth
One blinded and calibrated investigator recorded MPI at 6 sites around teeth using a PCP15 periodontal probe (HuFriedy® , Chicago, IL, USA). |
6 months
|
Plaque on teeth
Time Frame: 12 months
|
Modified plaque index (MPlI) measured at six sites per tooth
One blinded and calibrated investigator recorded MPI at 6 sites around teeth using a PCP15 periodontal probe (HuFriedy® , Chicago, IL, USA). |
12 months
|
Probing depth on implants
Time Frame: Baseline
|
Probing depth (PD) defined as the distance in mm, between the bottom of the pocket and the peri-implant mucosal margin (six sites per implant). One blinded and calibrated investigator recorded PD at 6 sites around implants, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA) Calibration was achieved in double measurement calibration sessions, with a gold standard, on six randomly selected patients within one week. The inter-examiner agreement resulted in a intraclass correlation coefficient (ICC)=0.93 for PD. |
Baseline
|
Probing depth on implants
Time Frame: 6 months
|
Probing depth (PD) defined as the distance in mm, between the bottom of the pocket and the peri-implant mucosal margin (six sites per implant). One blinded and calibrated investigator recorded PD at 6 sites around implants, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA) Calibration was achieved in double measurement calibration sessions, with a gold standard, on six randomly selected patients within one week. The inter-examiner agreement resulted in a intraclass correlation coefficient (ICC)=0.93 for PD. |
6 months
|
Probing depth on implants
Time Frame: 12 months
|
Probing depth (PD) defined as the distance in mm, between the bottom of the pocket and the peri-implant mucosal margin (six sites per implant). One blinded and calibrated investigator recorded PD at 6 sites around implants, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA) Calibration was achieved in double measurement calibration sessions, with a gold standard, on six randomly selected patients within one week. The inter-examiner agreement resulted in a intraclass correlation coefficient (ICC)=0.93 for PD. |
12 months
|
Probing depth on teeth
Time Frame: Baseline
|
Probing depth (PD) defined as the distance in mm, between the bottom of the pocket and the gingival margin (six sites per tooth). One blinded and calibrated investigator recorded PD at 6 sites around all teeth, using a PCP15 periodontal probe (HuFriedy® , Chicago, IL, USA). |
Baseline
|
Probing depth on teeth
Time Frame: 6 months
|
Probing depth (PD) defined as the distance in mm, between the bottom of the pocket and the gingival margin (six sites per tooth). One blinded and calibrated investigator recorded PD at 6 sites around all teeth, using a PCP15 periodontal probe (HuFriedy® , Chicago, IL, USA). |
6 months
|
Probing depth on teeth
Time Frame: 12 months
|
Probing depth (PD) defined as the distance in mm, between the bottom of the pocket and the gingival margin (six sites per tooth). One blinded and calibrated investigator recorded PD at 6 sites around all teeth, using a PCP15 periodontal probe (HuFriedy® , Chicago, IL, USA). |
12 months
|
Crown-length implant
Time Frame: Baseline
|
Crown-length implant (CLI), defined as the distance in mm, between the incisal/occlusal portion of the crown and the peri-implant mucosal margin at the mid-buccal site. One blinded and calibrated investigator recorded CLI around the selected implant, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA). Calibration was achieved in double measurement calibration sessions, with a gold standard , on six randomly selected patients within one week. The inter-examiner agreement resulted in a intraclass correlation coefficient of 0.96 for CLI. |
Baseline
|
Crown-length implant
Time Frame: 6 months
|
Crown-length implant (CLI), defined as the distance in mm, between the incisal/occlusal portion of the crown and the peri-implant mucosal margin at the mid-buccal site. One blinded and calibrated investigator recorded CLI around the selected implant, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA). Calibration was achieved in double measurement calibration sessions, with a gold standard , on six randomly selected patients within one week. The inter-examiner agreement resulted in a intraclass correlation coefficient of 0.96 for CLI. |
6 months
|
Crown-length implant
Time Frame: 12 months
|
Crown-length implant (CLI), defined as the distance in mm, between the incisal/occlusal portion of the crown and the peri-implant mucosal margin at the mid-buccal site. One blinded and calibrated investigator recorded CLI around the selected implant, using a plastic periodontal probe (PCV12, HuFriedy, Chicago, IL, USA). Calibration was achieved in double measurement calibration sessions, with a gold standard , on six randomly selected patients within one week. The inter-examiner agreement resulted in a intraclass correlation coefficient of 0.96 for CLI. |
12 months
|
Recession on teeth
Time Frame: Baseline
|
Recession (REC), defined as the distance in mm, between the gingival margin and the cements-enamel junction. One blinded and calibrated investigator recorded REC around all teeth using a PCP15 periodontal probe (HuFriedy® , Chicago, IL, USA). |
Baseline
|
Recession on teeth
Time Frame: 6 months
|
Recession (REC), defined as the distance in mm, between the gingival margin and the cements-enamel junction. One blinded and calibrated investigator recorded REC around all teeth using a PCP15 periodontal probe (HuFriedy® , Chicago, IL, USA). |
6 months
|
Recession on teeth
Time Frame: 12 months
|
Recession (REC), defined as the distance in mm, between the gingival margin and the cements-enamel junction. One blinded and calibrated investigator recorded REC around all teeth using a PCP15 periodontal probe (HuFriedy® , Chicago, IL, USA). |
12 months
|
Microbiological outcomes_total counts
Time Frame: Baseline
|
Pooled subgingival samples were obtained from the two most inflamed accessible sites of the selected implant in each patient. Samples were taken with two consecutive sterile medium paper-points (#30, Maillefer, Ballaigues, Switzerland) that were kept in place for 10 s and then transferred into a screw-capped vial containing 1.5 ml of reduced transport fluid (RTF) (Syed & Loesche 1972). Samples were transported to the microbiology laboratory within 2 h, where aliquots of 0.1 mL were plated in different culture media. Counts were transformed in colony-forming units (CFU) per mL of the original sample. Total anaerobic counts and counts of selected periodontal pathogens (A. actinomycetemcomitans, Tannerella forsythia, Porphyromonas gingivalis, Prevotella intermedia/nigrescens, Parvimonas micra, Eikenella corrodens, Campylobacter rectus and Fusobacterium nucleatum) were calculated. |
Baseline
|
Microbiological outcomes_total counts
Time Frame: 6 months
|
Pooled subgingival samples were obtained from the two most inflamed accessible sites of the selected implant in each patient. Samples were taken with two consecutive sterile medium paper-points (#30, Maillefer, Ballaigues, Switzerland) that were kept in place for 10 s and then transferred into a screw-capped vial containing 1.5 ml of reduced transport fluid (RTF) (Syed & Loesche 1972). Samples were transported to the microbiology laboratory within 2 h, where aliquots of 0.1 mL were plated in different culture media. Counts were transformed in colony-forming units (CFU) per mL of the original sample. Total anaerobic counts and counts of selected periodontal pathogens (A. actinomycetemcomitans, Tannerella forsythia, Porphyromonas gingivalis, Prevotella intermedia/nigrescens, Parvimonas micra, Eikenella corrodens, Campylobacter rectus and Fusobacterium nucleatum) were calculated. |
6 months
|
Microbiological outcomes_total counts
Time Frame: 12 months
|
Pooled subgingival samples were obtained from the two most inflamed accessible sites of the selected implant in each patient. Samples were taken with two consecutive sterile medium paper-points (#30, Maillefer, Ballaigues, Switzerland) that were kept in place for 10 s and then transferred into a screw-capped vial containing 1.5 ml of reduced transport fluid (RTF) (Syed & Loesche 1972). Samples were transported to the microbiology laboratory within 2 h, where aliquots of 0.1 mL were plated in different culture media. Counts were transformed in colony-forming units (CFU) per mL of the original sample. Total anaerobic counts and counts of selected periodontal pathogens (A. actinomycetemcomitans, Tannerella forsythia, Porphyromonas gingivalis, Prevotella intermedia/nigrescens, Parvimonas micra, Eikenella corrodens, Campylobacter rectus and Fusobacterium nucleatum) were calculated. |
12 months
|
Microbiological outcomes_frequency of detection
Time Frame: Baseline
|
The frequency of detection was calculated as presence/absence of each periodontal pathogen
|
Baseline
|
Microbiological outcomes_frequency of detection
Time Frame: 6 months
|
The frequency of detection was calculated as presence/absence of each periodontal pathogen
|
6 months
|
Microbiological outcomes_frequency of detection
Time Frame: 12 months
|
The frequency of detection was calculated as presence/absence of each periodontal pathogen
|
12 months
|
Microbiological outcomes_proportions
Time Frame: Baseline
|
The proportions for each bacterial species was calculated by dividing the counts of each pathogen by the total counts.
|
Baseline
|
Microbiological outcomes_proportions
Time Frame: 6 months
|
The proportions for each bacterial species was calculated by dividing the counts of each pathogen by the total counts.
|
6 months
|
Microbiological outcomes_proportions
Time Frame: 12 months
|
The proportions for each bacterial species was calculated by dividing the counts of each pathogen by the total counts.
|
12 months
|
Radiographic bone loss on implants
Time Frame: Baseline
|
Standardized periapical radiographs using the parallel technique (Rinn® system, Dentsply, Weybridge, United Kingdom) were used to evaluate changes in the radiographic marginal bone levels (MBL). Scanned images were measured both at the mesial and distal sites using as landmarks the implant shoulder and the first bone implant contact (BIC) of the selected implant using an image analysis software (J-image). After a session of calibration (ICC=0.99), two investigators performed all the radiographic measurements. |
Baseline
|
Radiographic bone loss on implants
Time Frame: 3 months
|
Standardized periapical radiographs using the parallel technique (Rinn® system, Dentsply, Weybridge, United Kingdom) were used to evaluate changes in the radiographic marginal bone levels (MBL). Scanned images were measured both at the mesial and distal sites using as landmarks the implant shoulder and the first bone implant contact (BIC) of the selected implant using an image analysis software (J-image). After a session of calibration (ICC=0.99), two investigators performed all the radiographic measurements. |
3 months
|
Radiographic bone loss on implants
Time Frame: 12 months
|
Standardized periapical radiographs using the parallel technique (Rinn® system, Dentsply, Weybridge, United Kingdom) were used to evaluate changes in the radiographic marginal bone levels (MBL). Scanned images were measured both at the mesial and distal sites using as landmarks the implant shoulder and the first bone implant contact (BIC) of the selected implant using an image analysis software (J-image). After a session of calibration (ICC=0.99), two investigators performed all the radiographic measurements. |
12 months
|
Staining
Time Frame: Baseline
|
Staining of teeth will be scored using the Gründemann modification of the stain index (GMSI) (Grundemann et al. 2000), recorded at nine areas per tooth (three mesial, three medial, three distal).
Stain will be graded using the intensity stain index of Lobene (1968).
|
Baseline
|
Staining
Time Frame: 6 months
|
Staining of teeth will be scored using the Gründemann modification of the stain index (GMSI) (Grundemann et al. 2000), recorded at nine areas per tooth (three mesial, three medial, three distal).
Stain will be graded using the intensity stain index of Lobene (1968).
|
6 months
|
Staining
Time Frame: 12 months
|
Staining of teeth will be scored using the Gründemann modification of the stain index (GMSI) (Grundemann et al. 2000), recorded at nine areas per tooth (three mesial, three medial, three distal).
Stain will be graded using the intensity stain index of Lobene (1968).
|
12 months
|
Adverse effect
Time Frame: Baseline
|
A questionnaire will be filled to assess the patient-based variables and side effects, by the patients.
They will be evaluated with a visual analogue scale (0-10)
|
Baseline
|
Adverse effect
Time Frame: 6 months
|
A questionnaire will be filled to assess the patient-based variables and side effects, by the patients.
They will be evaluated with a visual analogue scale (0-10)
|
6 months
|
Adverse effect
Time Frame: 12 months
|
A questionnaire will be filled to assess the patient-based variables and side effects, by the patients.
They will be evaluated with a visual analogue scale (0-10)
|
12 months
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Mariano Sanz, Doctor, University Complutense Madrid (UCM)
- Principal Investigator: David Herrera, Doctor, University Complutense Madrid
Publications and helpful links
General Publications
- Bollain J, Pulcini A, Sanz-Sanchez I, Figuero E, Alonso B, Sanz M, Herrera D. Efficacy of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth rinse in reducing inflammation around the teeth and implants: a randomized clinical trial. Clin Oral Investig. 2021 Apr;25(4):1729-1741. doi: 10.1007/s00784-020-03474-3. Epub 2020 Jul 31.
- Pulcini A, Bollain J, Sanz-Sanchez I, Figuero E, Alonso B, Sanz M, Herrera D. Clinical effects of the adjunctive use of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth rinse in the management of peri-implant diseases: A randomized clinical trial. J Clin Periodontol. 2019 Mar;46(3):342-353. doi: 10.1111/jcpe.13088.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 15/064
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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