- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04042194
Comparison of CTG and T-PRF on Peri-Implant Soft Tissue
Comparison of Connective Tissue Graft (CTG) and Titanium Prepared Platelet-Rich Fibrin (T-PRF) Inserted With a Double Layer Technique on Peri-Implant Soft Tissue Thickening: A Randomized Prospective Clinical Study
Study Overview
Status
Conditions
Detailed Description
Although connective tissue graft (CTG) is considered as the best technique for soft tissue augmentation, limited supply of donor tissue because of palatal vessels and nerves, and postoperative pain may require alternative methods.
The purpose of this study is to reduce the crestal bone resorption around the implant site by augmenting the Peri-Implant Soft Tissue with T-PRF (titanium prepared platelet-rich fibrin) or CTG and to compare the effectiveness of the two techniques.
Through simultaneous augmentation of the soft tissue by T-PRF or CTG, a total of 30 implants were implanted in 30 patients (12 males, 18 females) with a mean age of 38.4 years. In the test group, implants were placed in thin tissues and thickened with T- PRF membrane at the same time, while in the control group, implants were placed in thin tissues and thickened with CTG at the same time. During the surgery (T 0 ) and at postoperative 3 months (T 1 ), keratinised tissue width (KTW) and Peri-Implant soft tissue thickness (STT) were measured from three points: occlusal part of the alveolar crest (OAC), midbuccal mucosa level (MBML), and over 1 mm of mucogingival junction (MGJ1).
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
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Bolu, Turkey
- Bolu Abant İzzet Baysal University
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- patients older than 18 years,
- thin gingiva biotype,
- one missing tooth in the incisor, canine and premolar area and presence of two natural adjacent teeth
- no bone increasing procedures prior to and during dental implant,
Exclusion Criteria:
- history of a bleeding disorder or on anticoagulant therapy,
- immunocompromised state and debilitating disease,
- smoking and alcoholism,
- poor oral hygiene,
- diabetes.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Thickened with T-PRF
Following local anaesthesia, the measurement of soft tissue thickness at three points [1) occlusal part of the alveolar crest (OAC), 2) midbuccal mucosa level (MBML), 3) over 1 mm of mucogingival junction (MGJ1)] was performed with an endodontic spreader and digital caliber.
Following the mid-crestal incision, the buccal flap was raised with double layer technique, while the lingual flap was left to enable direct visibility.
The implant bed was drilled according to the manufacturer's protocol.
The implants (BEGO Semados® RS/RSX implant system, Bremen, Germany) were placed at the bony crest.
Right after the implant placement, the randomisation procedure was performed.
In this group, the implants were placed in thin tissues, and T-PRF was inserted in the prepared mucoperiosteal flap at the facial site and secured with horizontal mattresses.
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A total of 40 ml blood sample was collected from the antecubital vein of the patients' right or left arms with 10 ml injectors.
40 ml blood was transferred to a grade-IV titanium tube for the T-PRF group.
The titanium tubes containing the blood samples were instantly centrifuged in a tabletop centrifuge at room temperature.
The blood samples of the T-PRF group were centrifuged clockwise at 2700 RPM for 20 minutes.
Subsequent to the centrifugation process, the clots of the T-PRF group were removed from the tubes with sterile tweezers, separated from the RBC base with scissors, and left for over 20 minutes on sterile woven gauze to release the serum slowly from the collected clots.
The implants were placed in thin tissues, and the thickness of the thin tissues was simultaneously increased with T-PRF.
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Active Comparator: Thickened with CTG
Following local anaesthesia, the measurement of soft tissue thickness at three points [1) occlusal part of the alveolar crest (OAC), 2) midbuccal mucosa level (MBML), 3) over 1 mm of mucogingival junction (MGJ1)] was performed with an endodontic spreader and digital caliber.
Following the mid-crestal incision, the buccal flap was raised with double layer technique, while the lingual flap was left to enable direct visibility.
The implant bed was drilled according to the manufacturer's protocol.
The implants (BEGO Semados® RS/RSX implant system, Bremen, Germany) were placed at the bony crest.
Right after the implant placement, the randomisation procedure was performed.
In this group, the implants were placed in thin tissues, and CTG was inserted in the prepared mucoperiosteal flap at the facial site and secured with horizontal mattresses.
|
The implants were placed in thin tissues, and the thickness of the thin tissues was simultaneously increased with CTG.
Autogenous connective tissue graft was harvested according to a single incision technique.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Peri-implant Soft Tissue Thickness
Time Frame: Change from baseline soft tissue thickness at 3 months
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The measurement of soft tissue thickness at three points: occlusal part of the alveolar crest (OAC), midbuccal mucosa level (MBML), over 1 mm of mucogingival junction (MGJ1)]
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Change from baseline soft tissue thickness at 3 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Keratinised Tissue Width (KTW)
Time Frame: Change from baseline keratinised tissue width at 3 months
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The measurement of the keratinised tissue width between the cover screw and the mucogingival junction.
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Change from baseline keratinised tissue width at 3 months
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Gülbahar Ustaoğlu, Abant Izzet Baysal University
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2018/68
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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