- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04066543
TACE Combined With Anlotinib Treatment of Middle-advanced Hepatocellular Carcinoma (HCC) Patients
August 22, 2019 updated by: Zhejiang Cancer Hospital
A Single-center Randomized Controlled Clinical Trial of TACE Combined With Anlotinib Comparing With TACE in the Treatment of Middle-advanced Hepatocellular Carcinoma (HCC) Patients
This study was designed to evaluate the effectiveness of Anlotinib in middle-advanced Hepatocellular Carcinoma (HCC) Patients.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
The aim of this study is to include 40 patients with middle-advanced Hepatocellular Carcinoma .These patients were randomly allocated to TACE treatment group or TACE+Anlotinib treatment group.The treatment effectiveness, local tumor control and survival outcome between the two groups were compared.
Study Type
Interventional
Enrollment (Anticipated)
40
Phase
- Phase 2
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Zhejiang
-
Hangzhou, Zhejiang, China
- Recruiting
- Zhejiang Cancer Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 75 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Subject has no contraindication to chemotherapy, and has no obvious obstacles in the function of major organs such as heart, lung, liver and kidney;
- Subject has middle-advanced liver cancer of Barcelona Clinic Liver Cancer stages B/C ;
- Liver function child-pugh class A or B; Karnofsky (KPS) score > 60 points;
- Subject could not accept surgical resection or refuse surgical operation;and who did not receive other treatment before operation.
5.18~75 years old; ECOG PS score: 0-1 points; expected survival period is more than 3 months.
Exclusion Criteria:
- Subject has contraindications to chemotherapy;
- Subject has obstacle in the function of major organs such as heart, lung, liver and kidney;
- Severe coagulation dysfunction (prothrombin time > 18 s or hemorrhagic tendency);
- Uncontrollable hypertension and portal hypertension;
- Hepatic artery-portal vein or hepatic vein fistula or portal vein trunk cancer thrombus;
- A large amount of ascites or refractory ascites;
- With distant metastasis.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: TACE group
Device: Transcatheter arterial chemoembolization(TACE)
|
The modified Seldinger puncture was used to puncture the cutaneous-femoral artery, insert the catheter and perform hepatic artery angiography.
The location, morphology and blood supply of liver tissue lesions were comprehensively understood.
The use of chemotherapeutic drugs and the dosage of iodized oil as the embolic agent were determined according to the general situation.
The catheter was injected into the supply vessel of the tumor, and 5-FU and adriamycin were injected according to the situation.
The embolic agent was injected with iodized oil as carrier, mixed with chemotherapeutic drugs at the same time, and then assisted with gelatin sponge for embolization.
Antiemetic drugs were given before treatment and hepatoprotective drugs were given after operation.
Until the disease progresses.
|
Experimental: TACE+Anlotinib group
Device: Transcatheter arterial chemoembolization Drug: Anlotinib Anlotinib hydrochloride capsule, according to the recommended dose, po, qd, continuous oral 2 weeks stop for 1 week, 3 weeks for a cycle.
|
The modified Seldinger puncture was used to puncture the cutaneous-femoral artery, insert the catheter and perform hepatic artery angiography.
The location, morphology and blood supply of liver tissue lesions were comprehensively understood.
The use of chemotherapeutic drugs and the dosage of iodized oil as the embolic agent were determined according to the general situation.
The catheter was injected into the supply vessel of the tumor, and 5-FU and adriamycin were injected according to the situation.
The embolic agent was injected with iodized oil as carrier, mixed with chemotherapeutic drugs at the same time, and then assisted with gelatin sponge for embolization.
Antiemetic drugs were given before treatment and hepatoprotective drugs were given after operation.
Until the disease progresses.
Anlotinib hydrochloride capsule, according to the recommended dose, po, qd, continuous oral 2 weeks stop for 1 week, 3 weeks for a cycle.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
PFS
Time Frame: 12 months
|
Progress Free Survival
|
12 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Guoliang Shao, Zhejiang Cancer Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Anticipated)
August 30, 2019
Primary Completion (Anticipated)
May 30, 2021
Study Completion (Anticipated)
October 30, 2021
Study Registration Dates
First Submitted
August 22, 2019
First Submitted That Met QC Criteria
August 22, 2019
First Posted (Actual)
August 26, 2019
Study Record Updates
Last Update Posted (Actual)
August 26, 2019
Last Update Submitted That Met QC Criteria
August 22, 2019
Last Verified
August 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- ALTNZJ-002
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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