Role of Bronchoscopy in Bronchiectasis

Bronchiectasis Phenotypes ; Clinical , Radiological and Microbiological Assesment


Lead Sponsor: Assiut University

Source Assiut University
Brief Summary

Role of bronchoscopy in diagnosis of bronchiectasis in to different types

Detailed Description

Bronchiectasis is defined as abnormal chronic dilatation of one or more bronchi. Patients have a structural abnormality of the bronchial wall that predisposes them to bacterial infection likely due to impaired mucus clearance. A self-perpetuating vicious cycle of chest infections and chronic lung inflammation can lead to further damage of the bronchial wall and spread of disease to normal areas of bystander lung.(1)( Wilson et al,1997). A search for an underlying cause, which may be amenable to a targeted intervention to prevent ongoing damage, is essential but often fruitless, and the focus of therapy rapidly turns to empiric treatments to prevent infective exacerbations and retard disease progression. (2) ( Martinez-Garcia, et al,2005 ) The British Thoracic Society bronchiectasis management guidelines provide an in-depth summary of the available literature and are an excellent tool for guiding treatment decision making. However, they do not provide guidance on which patients are most likely to benefit from specific interventions. (3) (Pasteur et al, 2010). Disease severity in bronchiectasis is hard to define. Radiological severity grading scores exist; however, there is often a disconnect between radiological severity, symptom burden and disease progression (4) (Eshed et al, 2007). In 2014, competing bronchiectasis severity scores were published (FACED and the Bronchiectasis Severity Index (BSI). In each of these, a combination of patient demographics, symptom scores, comorbidities, and clinical, radiological and microbiological parameters were used to construct scoring systems, which, in the case of the BSI, predicted future mortality, and in the case of FACED, extended to prediction of future exacerbation frequency, hospitalisation and quality of life. (5, 6) (Chalmers et al, 2014; Martinez-Garcia et al, 2014). These severity scores have utility in identifying an individual's risk of disease progression to a predefined outcome and aid in subclassifying this heterogeneous group of patients in a manner that may pave the way to future mechanistic studies, which explain how these different disease phenotypes arise and inform the development of targeted therapeutics. (7) (Aliberti et al, 2007).

Overall Status Not yet recruiting
Start Date December 2019
Completion Date December 2020
Primary Completion Date September 2020
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Percentage of bronchiectatic patients with pseudomonal infection One week
Enrollment 60

Intervention Type: Procedure

Intervention Name: Bronchoscopy

Description: Role of bronchoscopy in diagnosis of bronchiectasis

Arm Group Label: Study group



Inclusion Criteria: - patients more than 18 years - Patients less than 70 years - Patients with bronchiectasis Exclusion Criteria: - patients with bronchial asthma or chronic obstructive pulmonary disease - patients with pneumonia - patients with T.B

Gender: All

Minimum Age: 18 Years

Maximum Age: 70 Years

Healthy Volunteers: Accepts Healthy Volunteers

Verification Date

December 2019

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Assiut University

Investigator Full Name: Esraa Yassin Ibrahim

Investigator Title: Principal investigator

Has Expanded Access No
Condition Browse
Number Of Arms 1
Arm Group

Label: Study group

Type: Experimental

Description: Patients with bronchiectasis

Study Design Info

Allocation: N/A

Intervention Model: Single Group Assignment

Primary Purpose: Diagnostic

Masking: None (Open Label)