- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04265859
Changes in Brain Function Through Repeated Emotion Regulation Training
July 31, 2023 updated by: Michael Stevens
This is a pilot study that will investigate how two psychotherapies (re-interpretation and mindfulness) alter brain function.
This information will be used to gain understanding of how repeated emotion regulation practices influence the brain and to develop a focused, tactic-based emotional regulation remediation approach for treatment of ADHD.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Detailed Description
The goal of this pilot study is to collect preliminary data that will allow the investigators to formulate theories about ER-related brain function change during intervention-like training that will be tested in larger, externally-funded grant proposals submitted to the National Institutes of Health.
The investigators are not especially interested in any existing specific, manualized therapeutic technique.
Existing ER-based psychotherapies typically incorporate a variety of related interventions, not all of which focus on the ER component itself.
Instead, the investigators will focus on the "building blocks" of such therapies, i.e., the ER interventions themselves and their effect on negative emotional reactions.
Here, the investigators ask a specific question - How does ER-elicited brain function change with repeated sessions of guided practice of various ER techniques?
In other words, does increasing familiarity or mastery of ER skills through practice change brain function, and how?
There are logical hypotheses about the likely nature of brain function changes that can be gleaned from prior neuroimaging research.
For instance, if prefrontal cortex activation is important to ER, perhaps practice simply increases such activation.
However, pilot work for the current NIMH R01 suggests instead that ER practice might work by enhancing the functional integration among key frontolimbic regions.
Complicating such hypotheses is the recognition that different ER tactics engage many distinct brain regions depending on which approach is employed.
So a participant's individual brain function differences prior to ER training might be a potent determinant for what sorts of neural changes result from repeated practice.
Because all these issues must be evaluated through the lens of a preliminary study before any coherent theoretical model can be formulated, a pilot study is proposed here.
Not only will this provide empirical data upon which to base future research, conducting such a pilot will showcase any methodological hurdles or challenges that need to be overcome in order to successfully conduct a larger-scale study.
Study Type
Interventional
Enrollment (Estimated)
40
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Karen L Kesten, MS
- Phone Number: (860) 545-7776
- Email: Karen.kesten@hhchealth.org
Study Contact Backup
- Name: Julie Reid, MS
- Phone Number: (860) 545-7788
- Email: Julie.reid@hhchealth.org
Study Locations
-
-
Connecticut
-
Hartford, Connecticut, United States, 06106
- Recruiting
- Institute of Living/Hartford Hospital
-
Contact:
- Karen L Kesten, MS
- Phone Number: 860-545-7776
- Email: Karen.kesten@hhchealth.org
-
Principal Investigator:
- Michael C Stevens, PhD
-
Contact:
- Julie Reid, MS
- Phone Number: (860) 545-7788
- Email: Julie.reid@hhchealth.org
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 50 years (Adult)
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
- Ages 18-50
- Right-handed
- High-school level of education (11th grade attainment for 18 year-olds is acceptable if they haven't completed their final year yet)
- >8th grade English reading level to complete self-report evaluations (most are only available in English).
- For the depressed group, elevated scores on the Beck Depression Inventory - II to validate depressive symptoms.
Exclusion Criteria:
- Head injury sufficient to have caused >30 minutes lost consciousness
- Past or current CNS disease (e.g., MS, epilepsy, tumor, etc.)
- Brain lesion identified by MR (structural MR scans will be reviewed by a radiologist for the presence of clinical neuropathology that may affect cognitive task performance)
- Hypertension or juvenile-onset diabetes (current treatment with antihypertensives or insulin)
- Current pregnancy (menstruating females will be tested)
- DSM-IV Axis I lifetime history of Bipolar disorder, PTSD, OCD, psychotic disorder, Tourette's disorder, or any Pervasive Developmental Disorder (e.g., Autistic disorder, PDD NOS, etc.)
- For the depressed group, current PTSD
- Current DSM-IV substance dependence, ADHD, Conduct Disorder, MDD
- Any current psychotropic medications
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Depressed
Participants in this group will be randomized to receive either the CBT training (n=10) or Mindfulness training (n=10).
|
The CBT-based regulation training involves using a cognitive strategy that instructs participants to reappraise situations in positive or less negative ways.
Other Names:
The MBT-based regulation training involves using a mindfulness strategy that instructs participants to notice and accept their feelings without judgment or intent to act upon them.
|
Other: Healthy Control
Participants in this group will be randomized to receive either the CBT training (n=10) or Mindfulness training (n=10).
|
The CBT-based regulation training involves using a cognitive strategy that instructs participants to reappraise situations in positive or less negative ways.
Other Names:
The MBT-based regulation training involves using a mindfulness strategy that instructs participants to notice and accept their feelings without judgment or intent to act upon them.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
fMRI Brain Scan
Time Frame: Visit one and repeated again at Visit two (approximately 4 weeks later)
|
fMRI-assessed brain function data, examined either to detect any changes in activation amplitude ("level of activity") in a priori ER-linked brain regions-of-interest (ROIs) or changes in the degree of functional connectivity among them.
|
Visit one and repeated again at Visit two (approximately 4 weeks later)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Beck Depression Inventory - II and State Trait Anxiety Inventory
Time Frame: Enrollment and repeated again at Visit two (approximately 4 weeks later)
|
Depression and anxiety scales (pre and post scores, as evidenced by a decrease in total scores from each scale)
|
Enrollment and repeated again at Visit two (approximately 4 weeks later)
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Michael C Stevens, PhD, Institute of Living/Hartford Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
March 1, 2021
Primary Completion (Estimated)
October 1, 2023
Study Completion (Estimated)
October 1, 2023
Study Registration Dates
First Submitted
February 10, 2020
First Submitted That Met QC Criteria
February 10, 2020
First Posted (Actual)
February 12, 2020
Study Record Updates
Last Update Posted (Actual)
August 2, 2023
Last Update Submitted That Met QC Criteria
July 31, 2023
Last Verified
August 1, 2022
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- R-HCC-2016-0177
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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