- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04623931
Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas
Phase II Trial of Treatment Intensification for IDH Wildtype, Non-Histological Glioblastoma, Gliomas (IDH Wildtype Lower Grade Glioma Treatment Intensification)
Study Overview
Status
Conditions
Detailed Description
PRIMARY OBJECTIVE:
I. To determine the progression free survival (PFS) based on Response Assessment in Neuro-Oncology (RANO) imaging criteria from start of treatment with concurrent chemoradiation (CRT) and adjuvant temozolomide (TMZ).
SECONDARY OBJECTIVE:
I. To determine the 3-year overall survival (OS) of isocitrate dehydrogenase (IDH) wild-type grade II and grade III gliomas with dose escalation radiation with concurrent chemoradiation therapy.
EXPLORATORY OBJECTIVES:
I. To assess local control patterns (site of 1st progression). II. To evaluate neuro-cognitive function by the Neurocognitive Clinical Trial Battery (CTB).
III. To evaluate the treatment related symptoms, overall symptom impact, and disease related factor groupings utilizing the M.D. Anderson Symptom Inventory Brain Tumor (MDASI-BT).
IV. To assess the quality of life.
OUTLINE:
Patients receive temozolomide orally (PO) daily and radiation therapy over 5 days a week (weekdays only) for 6 weeks. Beginning 28 days after the last dose of radiation therapy, patients receive temozolomide PO for 12 months in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up at 1, 3, 5, 7, 9, 12, 15, 18, 21, 24, 28, 32, and 36 months.
Study Type
Enrollment (Estimated)
Phase
- Phase 2
Contacts and Locations
Study Contact
- Name: Debra N Yeboa
- Phone Number: 713-563-2300
- Email: dnyeboa@mdanderson.org
Study Locations
-
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Texas
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Houston, Texas, United States, 77030
- Recruiting
- M D Anderson Cancer Center
-
Contact:
- Debra N. Yeboa
- Phone Number: 713-563-2300
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Principal Investigator:
- Debra N. Yeboa
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Historical grade II and III gliomas IDH wildtype gliomas by including; diffuse astrocytoma, anaplastic astrocytoma, oligodendroglioma, anaplastic oligodendroglioma, oligoastrocytoma, anaplastic oligoastrocytoma
- IDH wildtype gliomas (molecularly defined high grade glioma or molecularly defined glioblastoma [GBM])
- History & physical exam, and Karnofsky performance status (KFS) of >= 70 within 30 days prior to enrollment
- Post-operative magnetic resonance imaging (MRI) with contrast is mandatory and necessary for radiation therapy (RT) planning
- Thin-slice (< 1.5 mm) three-dimensional (3D) T1 pre and post contrast and axial T2/fluid-attenuated inversion recovery (FLAIR) sequences for planning purposes are highly encouraged to obtain.
- Absolute neutrophil count (ANC) >= 1,500 cells/mm^3 (within 60 days prior to registration)
- Platelets >= 100,000 cells/mm^3 (within 60 days prior to registration)
- Hemoglobin >= 10.0 g/dl (within 60 days prior to registration) (Note: The use of transfusion or other intervention to achieve hemoglobin [Hgb] >= 10.0 g/dl is acceptable)
- Bilirubin =< 1.5 upper limit of normal (ULN) (within 60 days prior to registration)
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN (within 60 days prior to registration)
- Blood urea nitrogen (BUN) < 30 mg/dl (within 60 days prior to registration)
- Serum creatinine < 1.5 mg/dl (within 60 days prior to registration)
Exclusion Criteria:
- Definitive clinical or radiologic evidence of metastatic disease; if applicable
- Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years. (For example, carcinoma in situ of the breast, oral cavity or cervix are permissible)
- Prior cranial radiotherapy or radiotherapy to the head and neck where potential field overlaps would exist
- Prior chemotherapy or radiotherapy for any brain tumor
- Histologic diagnosis of gliosarcoma World Health Organization (WHO grade IV) or pilocytic astrocytoma (WHO grade I)
- Multicentric glioblastoma
- Leptomeningeal disease
- Inability to undergo MRI with and without contrast
Severe, active co-morbidity defined as follows:
- Unstable angina or congestive heart failure requiring hospitalization within 6 months prior to enrollment
Transmural myocardial infarction within the last 6 months prior to registration. Evidence of recent myocardial infarction or ischemia by the findings of S-T elevations of >= 2 mm using the analysis of an electrocardiogram (EKG) performed within 28 days prior to registration. (Note: EKG to be performed only if clinical suspicion of cardiac issue)
• New York Heart Association grade II or greater congestive heart failure requiring hospitalization within 12 months prior to registration
- Serious and inadequately controlled arrhythmia at step 2 registration
- Serious or non-healing wound, ulcer or bone fracture or history of abdominal fistula, intra-abdominal abscess requiring major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to registration, with the exception of the craniotomy for surgical resection
- Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
- Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for coagulation parameters are not required for entry into this protocol
- Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
- Human immunodeficiency virus (HIV) positive with CD4 count < 200 cells/microliter. Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; note, however, that HIV testing is not required for entry into this protocol. The need to exclude patients with AIDS from this protocol is because the treatments involved in this protocol may be significantly immunosuppressive with potentially fatal outcomes in patients already immunosuppressed
- Any other severe immunocompromised condition
- Active connective tissue disorders, such as lupus or scleroderma that in the opinion of the treating physician may put the patient at high risk for radiation toxicity
- End-stage renal disease (i.e., on dialysis or dialysis has been recommended)
- Any other major medical illnesses or psychiatric treatments that in the investigator's opinion will prevent administration or completion of protocol therapy
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Treatment (temozolomide, radiation therapy)
Patients receive temozolomide PO daily and radiation therapy over 5 days a week (weekdays only) for 6 weeks.
Beginning 28 days after the last dose of radiation therapy, patients receive temozolomide PO for 12 months in the absence of disease progression or unacceptable toxicity.
|
Ancillary studies
Other Names:
Ancillary studies
Undergo radiation therapy
Other Names:
Given PO
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Progression free survival (PFS)
Time Frame: From start of treatment until objective tumor progression or death, whichever happens first, assessed up to 52 months
|
Tumor progression is defined by the Response Assessment in Neuro-Oncology glioma criteria.
PFS time will be estimated using the Kaplan-Meier method.
The 1-year PFS rate will be estimated along with a 95% confidence interval.
Patient or tumor characteristics (ex.
grade, age, etc) will be compared within the single study cohort.
Cox regression models will be applied to assess the effect of covariates of interest on PFS.
|
From start of treatment until objective tumor progression or death, whichever happens first, assessed up to 52 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Overall survival (OS) rate
Time Frame: From start of treatment until death from any cause, assessed at 3 years
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The 3-year OS rate is defined as the proportion of participants that are alive at 3-year after the start of treatment, which will be estimated along a 95% confidence interval.
OS time will be estimated using the Kaplan-Meier method.
Patient or tumor characteristics (ex.
grade, age, etc) will be compared within the single study cohort.
Cox regression models will be applied to assess the effect of covariates of interest on OS.
|
From start of treatment until death from any cause, assessed at 3 years
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Local control patterns (site of 1st progression)
Time Frame: Up to 3 years
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Will be summarized with frequency and proportion.
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Up to 3 years
|
Neuro-cognitive function
Time Frame: Up to 3 years
|
Assessed by the Neurocognitive Clinical Trial Battery, and summarized with descriptive summary statistics.
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Up to 3 years
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Symptom burden
Time Frame: Up to 3 years
|
Assessed by the M.D. Anderson Symptom Inventory Brain Tumor (MDASI-BT), and summarized using standard descriptive statistics such as mean, standard deviation, median and range.
Wilcoxon rank-sum test or Kruskal Wallis test will be used to examine the difference on MDASI-BT between or among patients' characteristics groups.
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Up to 3 years
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Quality of life
Time Frame: Up to 3 years
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Assessed by linear analog self-assessment (LASA) scale, will be summarized using standard descriptive statistics such as mean, standard deviation, median and range.
Wilcoxon rank-sum test or Kruskal-Wallis test will be used to examine the difference on LASA scale between or among patients' characteristics groups.
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Up to 3 years
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Debra N Yeboa, M.D. Anderson Cancer Center
Publications and helpful links
Helpful Links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Neoplasms by Histologic Type
- Neoplasms
- Neoplasms, Glandular and Epithelial
- Neoplasms, Neuroepithelial
- Neuroectodermal Tumors
- Neoplasms, Germ Cell and Embryonal
- Neoplasms, Nerve Tissue
- Glioblastoma
- Glioma
- Astrocytoma
- Oligodendroglioma
- Molecular Mechanisms of Pharmacological Action
- Antineoplastic Agents
- Antineoplastic Agents, Alkylating
- Alkylating Agents
- Temozolomide
Other Study ID Numbers
- 2019-0715 (Other Identifier: M D Anderson Cancer Center)
- NCI-2019-08264 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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