- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04767503
Anesthesia on Gut Microbiota and Metabolomics
The Impact of Different Anesthetic Methods on the Interaction of Gut Microbiota and Metabolomics Following Hepatectomy
Hepatectomies are performed for the treatment of hepatic tumors and livingdonor liver transplantation. The success of liver resection relies on the remnant liver's ability to regenerate after major tissue loss. Despite appropriate liver remnant volume after resection ensures the liver's ability to regenerate, regeneration progresses at variable ratesin patients.
Many researches have established a relationship between the gut microbiome and patients with liver disease such as liver cirrhosis, alcoholic liver disease and obesity related liver diseases. These liver disorders are associated with bacterial overgrowth, dysbiosis, and increased intestinal permeability. However, the relationship between hepatectomy and microbiota has not been fully investigated.
The measurement of small-molecule metabolites has been an integral part of clinical practice including the familiar clinical standards like glucose and creatinine. Metabolomics, however, is able to measure all the metabolites at once. It is possible to get a far more comprehensive picture of what is happening to a patient's physiology or metabolism. Although gut microbiota has been shown to be related to liver disease and liver regeneration. Obtaining a more comprehensive analysis by identifying not only the microbial composition but also the metabolites will be more insightful.
Many routine perioperative aspects of surgical care can impact the state of the microbiome and therefore can impact clinical outcomes, like bowel preparation and antibiotics. Potential factors affecting the gut microbiota also include perioperative manipulation, stress released hormones, and opioids. Maintenance of proper anesthetic depth is beneficial to attenuate surgical stress. General anesthesia including volatile anesthetics and opioids, is associated with altered gut microbiota which might in turn affect liver regeneration. In this regard, perioperative care such as anesthesia, is one of the key points for the success of a liver resection. However, which anesthetic method is preferable regarding postoperative outcome or recovery is controversial.
In this study, the study population will include liver tumor resection and living donor hepatectomy. We aimed to 1) identify the relationship of hepatectomy and changes of gut microbiota and metabolomics. 2) investigate the impact of different anesthetic methods on the interaction of gut microbiota and metabolomics.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Kuang-Cheng Chan, M.D.,PhD.
- Phone Number: 62158 +886-2-23123456
- Email: jkjchan@gmail.com
Study Locations
-
-
-
Taipei, Taiwan, 100
- Recruiting
- Department of Anesthesiology
-
Contact:
- Kuang-Cheng Chan, M.D.,PhD
- Phone Number: 62158 +886-2-23123456
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Expected to receive hepatic tumor resection in National Taiwan University Hospital, age between 20 and 75 years old.
Exclusion Criteria:
- Previous use of antibiotics within four weeks.
- Previous gastrointestinal surgery.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: HEALTH_SERVICES_RESEARCH
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: DOUBLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
ACTIVE_COMPARATOR: Propofol
Maintence of anesthesia during the operation using target control infusion with propofol 1mg/ml with bispetral index(BIS) in the range 40-60.
|
Maintence of anestheisa with propofol guided by the bispectral index in the range 40-60.
|
SHAM_COMPARATOR: Desflurane
Maintence of anesthesia during the operation using inhalational agent desflurane with 0.5 to 1.5 minimal alveolar concentration (MAC) with bispetral index(BIS) in the range 40-60.
|
Maintence of anestheisa with desflurane guided by the bispectral index in the range 40-60.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Microbiota analysis
Time Frame: one month
|
16S metagenomic sequence processing
|
one month
|
Metabolomics
Time Frame: one month
|
Changes of metabolites in serum measured by metabolomic mass spectrometry
|
one month
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
I-FEED scoring
Time Frame: one week
|
I-FEED scoring system for postoperative gastrointestinal function:
Total score: 0-2 normal, 3-5 postoperative GI intolerance, >6 postoperative GI dysfunction |
one week
|
Collaborators and Investigators
Investigators
- Principal Investigator: Kuang-Cheng Chan, M.D.,PhD., Department of Anesthesiology, National Taiwan University Hospital
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ANTICIPATED)
Study Completion (ANTICIPATED)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Digestive System Diseases
- Neoplasms
- Neoplasms by Site
- Digestive System Neoplasms
- Liver Diseases
- Liver Neoplasms
- Physiological Effects of Drugs
- Central Nervous System Depressants
- Anesthetics, Intravenous
- Anesthetics, General
- Anesthetics
- Hypnotics and Sedatives
- Anesthetics, Inhalation
- Propofol
- Desflurane
Other Study ID Numbers
- 201912148MINB
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Hepatic Tumor Resection
-
Nuh RahbariCompleted
-
Polyganics BVGenaeCompletedPancreatectomy | Hepatic ResectionGermany
-
University Medical Center GroningenCompletedElective Hepatic ResectionNetherlands
-
Kasr El Aini HospitalRecruitingAnalgesia | Hepatic Resection SurgeryEgypt
-
Assistance Publique - Hôpitaux de ParisTerminatedLaparotomy | Hepatic ResectionFrance
-
Baxter Healthcare CorporationBaxter Innovations GmbHCompleted
-
University Hospital Inselspital, BerneTerminatedLiver Failure | Liver ResectionSwitzerland
-
University of MilanCompletedHepatectomy | Bile Leak | Hepatic Resection | Biliary Fistula | Liver ResectionItaly
-
Peking University First HospitalPeking University; Peking University People's Hospital; Peking University Third... and other collaboratorsCompletedElderly | Long-term Outcome | Malignant Tumor | Epidural Anesthesia | Surgical ResectionChina
-
Fudan UniversityUnknownPredictive Value of ICG Clearance Measurement During Selective Hepatic Vascular Trial Clamping on Remnant Liver Function After Anatomic Liver ResectionChina
Clinical Trials on Propofol
-
Hopital FochCompleted
-
Konkuk University Medical CenterCompletedCoronary Artery Disease | Valvular Heart DiseaseKorea, Republic of
-
University Medical Center GroningenCompletedAnesthesia | Hemodynamic Instability | Interaction | Disorder of Oxygen TransportNetherlands
-
Asan Medical CenterCompletedPopulation Pharmacokinetics/Pharmacodynamics (PK/PD) of Microemulsion Propofol in Healthy VolunteersHealthyKorea, Republic of
-
Tiva GroupMedtronic - MITGCompleted
-
Pontificia Universidad Catolica de ChileCompletedSurgery | Anesthesia | Depth of Anesthesia | NeonateChile
-
Mansoura UniversityCompleted
-
KVG Medical College and HospitalUnknown
-
Acibadem UniversityCompleted